PMID- 35354080
OWN - NLM
STAT- MEDLINE
DCOM- 20220419
LR  - 20220505
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 356
DP  - 2022 Jun 1
TI  - Serial measurement of B-type natriuretic peptide and future cardiovascular events 
      in patients with type 2 diabetes mellitus without known cardiovascular disease.
PG  - 98-104
LID - S0167-5273(22)00443-0 [pii]
LID - 10.1016/j.ijcard.2022.03.049 [doi]
AB  - BACKGROUND: In patients with type 2 diabetes mellitus (T2DM) without known 
      cardiovascular disease, the association between B-type natriuretic peptide (BNP) 
      and cardiovascular events except for heart failure has not been elucidated. We 
      aimed to investigate this association in high-risk T2DM patients. METHODS: We 
      analyzed the association between BNP and cardiovascular events, including 
      coronary, cerebral, renal, and vascular events or cardiovascular death based on 
      the single and serial measurement of BNP in T2DM patients with retinopathy and 
      hyperlipidemia without known cardiovascular disease enrolled in the EMPATHY 
      study. RESULTS: Data from 4966 patients were analyzed for baseline BNP analysis. 
      The median BNP value was 15.0 pg/mL. When analyzed in quartiles of baseline BNP 
      (interquartile range 7.5-29.2 pg/mL), Q2, Q3, and Q4 were associated with 
      cardiovascular events compared with Q1 (hazard ratio [HR]: Q2, 1.91 [P = 0.003]; 
      Q3, 1.63 [P = 0.031]; Q4, 3.20 [P < 0.001]). The analysis of 12-month BNP showed 
      similar associations. In serial BNP measurement, compared with low-low BNP group 
      (baseline </=35 pg/mL and 12-month </=35 pg/mL), low-high BNP group as well as 
      high-high BNP group was associated with cardiovascular events (HR: low-high, 2.05 
      [P = 0.004]; high-high, 2.07 [P = 0.001]) and non-renal cardiovascular events. 
      High-low BNP group tended to be associated with non-renal cardiovascular events 
      (HR vs low-low: 2.05 [P = 0.056]). CONCLUSIONS: BNP levels were associated with 
      first cardiovascular events except for heart failure in T2DM patients with 
      retinopathy and hyperlipidemia. Serial BNP measurement may be useful in further 
      stratifying high-risk patients among this T2DM population.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Ikeda, Shota
AU  - Ikeda S
AD  - Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu 
      University, Fukuoka, Japan.
FAU - Shinohara, Keisuke
AU  - Shinohara K
AD  - Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu 
      University, Fukuoka, Japan; Center for Clinical and Translational Research, 
      Kyushu University Hospital, Fukuoka, Japan. Electronic address: 
      shinohara.keisuke.727@m.kyushu-u.ac.jp.
FAU - Enzan, Nobuyuki
AU  - Enzan N
AD  - Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu 
      University, Fukuoka, Japan.
FAU - Matsushima, Shouji
AU  - Matsushima S
AD  - Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu 
      University, Fukuoka, Japan.
FAU - Tohyama, Takeshi
AU  - Tohyama T
AD  - Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu 
      University, Fukuoka, Japan; Center for Clinical and Translational Research, 
      Kyushu University Hospital, Fukuoka, Japan.
FAU - Funakoshi, Kouta
AU  - Funakoshi K
AD  - Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu 
      University, Fukuoka, Japan; Center for Clinical and Translational Research, 
      Kyushu University Hospital, Fukuoka, Japan.
FAU - Kishimoto, Junji
AU  - Kishimoto J
AD  - Center for Clinical and Translational Research, Kyushu University Hospital, 
      Fukuoka, Japan.
FAU - Itoh, Hiroshi
AU  - Itoh H
AD  - Department of Endocrinology, Metabolism and Nephrology, Keio University School of 
      Medicine, Tokyo, Japan.
FAU - Komuro, Issei
AU  - Komuro I
AD  - Department of Cardiovascular Medicine, The University of Tokyo Graduate School of 
      Medicine, Tokyo, Japan.
FAU - Tsutsui, Hiroyuki
AU  - Tsutsui H
AD  - Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu 
      University, Fukuoka, Japan.
LA  - eng
PT  - Journal Article
DEP - 20220327
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 0 (Biomarkers)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Biomarkers
MH  - *Cardiovascular Diseases/diagnosis/epidemiology
MH  - *Diabetes Mellitus, Type 2/diagnosis/epidemiology
MH  - *Heart Failure
MH  - Humans
MH  - Natriuretic Peptide, Brain
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - *Retinal Diseases
OTO - NOTNLM
OT  - B-type natriuretic peptide
OT  - Cardiovascular events
OT  - Type 2 diabetes mellitus
EDAT- 2022/03/31 06:00
MHDA- 2022/04/20 06:00
CRDT- 2022/03/30 20:01
PHST- 2022/02/07 00:00 [received]
PHST- 2022/03/23 00:00 [revised]
PHST- 2022/03/24 00:00 [accepted]
PHST- 2022/03/31 06:00 [pubmed]
PHST- 2022/04/20 06:00 [medline]
PHST- 2022/03/30 20:01 [entrez]
AID - S0167-5273(22)00443-0 [pii]
AID - 10.1016/j.ijcard.2022.03.049 [doi]
PST - ppublish
SO  - Int J Cardiol. 2022 Jun 1;356:98-104. doi: 10.1016/j.ijcard.2022.03.049. Epub 
      2022 Mar 27.