PMID- 35354099 OWN - NLM STAT- MEDLINE DCOM- 20220517 LR - 20220716 IS - 1879-1379 (Electronic) IS - 0022-3956 (Print) IS - 0022-3956 (Linking) VI - 150 DP - 2022 Jun TI - Cord serum brain-derived neurotrophic factor levels at birth associate with temperament outcomes at one year. PG - 47-53 LID - S0022-3956(22)00131-5 [pii] LID - 10.1016/j.jpsychires.2022.03.009 [doi] AB - Altered serum levels of brain-derived neurotrophic factor (BDNF) are consistently linked with neurological disorders. BDNF is also increasingly implicated in the pathogenesis of neurodevelopmental disorders, particularly those found more frequently in males. At birth, male infants naturally have significantly lower serum BDNF levels ( approximately 10-20% lower than females), which may render them more vulnerable to neurodevelopmental disorders. We previously characterized serum BDNF levels in mothers and their newborn infants as part of the Grown in Wales Study. Here, we analyzed whether cord serum BDNF levels at birth correlate with sex-specific outcomes at one year. The Bayley Scale of Infant Development, Third Edition (BSID-III) and Laboratory Temperament Assessment Battery (Lab-TAB) tasks were used to assess infant behavior and neurodevelopment at 12-14 months (mean +/- SD: 13.3 +/- 1.6 months; 46% male; n = 56). We found no relationship between serum BDNF levels at birth and BSID-III neurodevelopmental outcomes (cognitive or language), nor with infant behaviors in the Lab-TAB unpredictable mechanical toy or maternal separation tasks. In the sustained attention task, there was a significant positive relationship between serum BDNF and infant negative affect (B = 0.06, p = 0.018) and, for boys only, between serum BDNF and intensity of facial interest (B = 0.03, p = 0.005). However, only the latter remained after correction for multiple testing. This sex-specific association between cord serum BDNF and a parameter of attention at 12-14 months provides some support for the hypothesis that reduced serum BDNF levels at birth are linked to an increased risk for neurodevelopmental disorders. CI - Copyright (c) 2022 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Dingsdale, Hayley AU - Dingsdale H AD - School of Biosciences, Cardiff University, Cardiff, CF10 3AX, UK. FAU - Garay, Samantha M AU - Garay SM AD - School of Biosciences, Cardiff University, Cardiff, CF10 3AX, UK. FAU - Tyson, Hannah R AU - Tyson HR AD - School of Biosciences, Cardiff University, Cardiff, CF10 3AX, UK. FAU - Savory, Katrina A AU - Savory KA AD - School of Biosciences, Cardiff University, Cardiff, CF10 3AX, UK. FAU - Sumption, Lorna A AU - Sumption LA AD - School of Biosciences, Cardiff University, Cardiff, CF10 3AX, UK. FAU - Kelleher, Jemima S AU - Kelleher JS AD - School of Biosciences, Cardiff University, Cardiff, CF10 3AX, UK. FAU - Langley, Kate AU - Langley K AD - School of Psychology, Cardiff University, Cardiff, CF10 3AT, UK. FAU - Van Goozen, Stephanie AU - Van Goozen S AD - Cardiff University Centre for Human Developmental Science, School of Psychology, Cardiff University, Cardiff, CF10 3AT, UK. FAU - John, Rosalind M AU - John RM AD - School of Biosciences, Cardiff University, Cardiff, CF10 3AX, UK. Electronic address: JohnRM@cardiff.ac.uk. LA - eng GR - MR/N013794/1/MRC_/Medical Research Council/United Kingdom GR - BB/M009122/1/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom GR - MR/M013960/1/MRC_/Medical Research Council/United Kingdom PT - Journal Article DEP - 20220312 PL - England TA - J Psychiatr Res JT - Journal of psychiatric research JID - 0376331 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - *Brain-Derived Neurotrophic Factor/blood MH - Female MH - Fetal Blood MH - Humans MH - Infant MH - Infant, Newborn MH - Male MH - Mothers MH - Neurodevelopmental Disorders MH - *Temperament PMC - PMC9225956 OTO - NOTNLM OT - Attention OT - Brain-derived neurotrophic factor OT - Neurodevelopment OT - Temperament EDAT- 2022/03/31 06:00 MHDA- 2022/05/18 06:00 PMCR- 2022/06/01 CRDT- 2022/03/30 20:01 PHST- 2021/11/04 00:00 [received] PHST- 2022/01/31 00:00 [revised] PHST- 2022/03/04 00:00 [accepted] PHST- 2022/03/31 06:00 [pubmed] PHST- 2022/05/18 06:00 [medline] PHST- 2022/03/30 20:01 [entrez] PHST- 2022/06/01 00:00 [pmc-release] AID - S0022-3956(22)00131-5 [pii] AID - 10.1016/j.jpsychires.2022.03.009 [doi] PST - ppublish SO - J Psychiatr Res. 2022 Jun;150:47-53. doi: 10.1016/j.jpsychires.2022.03.009. Epub 2022 Mar 12.