PMID- 35354154
OWN - NLM
STAT- MEDLINE
DCOM- 20220504
LR  - 20220504
IS  - 1423-0313 (Electronic)
IS  - 0031-7012 (Linking)
VI  - 107
IP  - 5-6
DP  - 2022
TI  - The Efficacy and Safety of Botulinum Toxin Type A Injections in Improving Facial 
      Scars: A Systematic Review and Meta-Analysis.
PG  - 241-249
LID - 10.1159/000522396 [doi]
AB  - BACKGROUND: Botulinum toxin type A (BTA) has a wide range of clinical 
      applications, and its use in improving aesthetics is one of them. The aim of this 
      study was to better assess the efficacy and safety of BTA in patients with facial 
      scars. SUMMARY: We extracted the data of the visual analog scale (VAS) score, 
      Vancouver scar scale (VSS) score, scar width, observer scar assessment scale 
      (OSAS), patient scar assessment scale (PSAS), and/or drug-related adverse events. 
      Five studies provided the data of VAS score, and the results showed that the VAS 
      score in the BTA group was significantly higher than that in the control group. 
      Three randomized controlled trials (RCTs) reported the VSS score. A statistically 
      significant difference exists between the BTA group and the control group. Three 
      RCTs reported the scar width after BTA treatment. A more favorable change was 
      found in the BTA group with scar width even without statistical significance. 
      Data about the OSAS and PSAS scores were available in two trials. There was no 
      significant difference in OSAS and PSAS scores between the BTA group and the 
      control group. Only three studies recorded three slight adverse events. There 
      were no reports of severe complications. In conclusions, this study demonstrated 
      that BTA has the potential to improve facial scars with an acceptable safety 
      profile.
CI  - (c) 2022 S. Karger AG, Basel.
FAU - Wang, Wendi
AU  - Wang W
AD  - Department of Plastic and Burn Surgery, Tianjin First Central Hospital, Tianjin, 
      China.
FAU - Liu, Guangjing
AU  - Liu G
AD  - Department of Plastic and Burn Surgery, Tianjin First Central Hospital, Tianjin, 
      China.
FAU - Li, Xiaobing
AU  - Li X
AD  - Department of Plastic and Burn Surgery, Tianjin First Central Hospital, Tianjin, 
      China.
LA  - eng
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20220330
PL  - Switzerland
TA  - Pharmacology
JT  - Pharmacology
JID - 0152016
RN  - EC 3.4.24.69 (Botulinum Toxins, Type A)
SB  - IM
MH  - *Botulinum Toxins, Type A/adverse effects
MH  - Cicatrix/drug therapy/etiology
MH  - Humans
MH  - *Sleep Apnea, Obstructive/complications/drug therapy
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Botulinum toxin type A
OT  - Facial scars
OT  - Meta-analysis
OT  - Randomized controlled trials
EDAT- 2022/03/31 06:00
MHDA- 2022/05/06 06:00
CRDT- 2022/03/30 20:02
PHST- 2021/06/08 00:00 [received]
PHST- 2022/01/24 00:00 [accepted]
PHST- 2022/03/31 06:00 [pubmed]
PHST- 2022/05/06 06:00 [medline]
PHST- 2022/03/30 20:02 [entrez]
AID - 000522396 [pii]
AID - 10.1159/000522396 [doi]
PST - ppublish
SO  - Pharmacology. 2022;107(5-6):241-249. doi: 10.1159/000522396. Epub 2022 Mar 30.