PMID- 35355957
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220401
IS  - 1319-562X (Print)
IS  - 2213-7106 (Electronic)
IS  - 2213-7106 (Linking)
VI  - 29
IP  - 5
DP  - 2022 May
TI  - Ameliorative effects of Anchomanes difformis aqueous extract against oxidative 
      stress in the testes and epididymis of streptozotocin-induced diabetic male 
      Wistar rats.
PG  - 3122-3132
LID - 10.1016/j.sjbs.2022.03.015 [doi]
AB  - Hyperglycemia is a central trait of diabetes mellitus (DM) and is linked to an 
      increase in free radical generation and oxidative stress in the testes, resulting 
      in testicular tissue damage and male infertility. Synthetic medicines are 
      commonly used to manage diabetes; however, they are costly and associated with 
      adverse effects. As a result, the search for a safer and affordable alternative 
      from medicinal plants that contain antioxidants has become imperative to scavenge 
      free radicals caused by hyperglycaemia, thereby alleviating male reproductive 
      dysfunction. Therefore, the present aimed to investigate the ameliorative effects 
      of Anchomanes difformis aqueous extract against oxidative stress in the testes 
      and epididymis of streptozotocin-induced diabetic male Wistar rats. A total of 64 
      male Wistar rats (eight weeks old) weighing 180 +/- 10 mg/kg were divided into 
      seven groups at random. Type 2 diabetic mellitus (T2DM) was induced by 
      streptozotocin (STZ) and a 10% fructose injection intraperitoneally using 
      40 mg/kg body weight rats. The levels of malondialdehyde (MDA), catalase (CAT), 
      and superoxide dismutase (SOD) activity, reduced glutathione (GSH) concentration, 
      and ferric reducing antioxidant (FRAP) as well as 2, 2-diphenyl-1-picrylhydrazyl 
      (DPPH) values were used to establish the testicular oxidative status. It was 
      found that A. difformis extract significantly (p < 0.05) lowered MDA levels in 
      diabetic rats. Both CAT and SOD activity were significantly (p < 0.05) lower 
      following induction of DM and increased (p < 0.05) after treating with A. 
      difformis. The findings of this study show that A. difformis extract could be a 
      promising source of lead compounds for the development of a therapeutic agent to 
      treat male infertility caused by DM complications.
CI  - (c) 2022 The Authors.
FAU - Nethengwe, Murendeni
AU  - Nethengwe M
AD  - Phytomedicine and Phytochemistry Group, Department of Biomedical Sciences, 
      Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, 
      Bellville 7535, South Africa.
FAU - Okaiyeto, Kunle
AU  - Okaiyeto K
AD  - Phytomedicine and Phytochemistry Group, Department of Biomedical Sciences, 
      Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, 
      Bellville 7535, South Africa.
FAU - Oguntibeju, Oluwafemi O
AU  - Oguntibeju OO
AD  - Phytomedicine and Phytochemistry Group, Department of Biomedical Sciences, 
      Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, 
      Bellville 7535, South Africa.
FAU - Brooks, Nicole L
AU  - Brooks NL
AD  - Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, 
      Bellville 7535, South Africa.
LA  - eng
PT  - Journal Article
DEP - 20220312
PL  - Saudi Arabia
TA  - Saudi J Biol Sci
JT  - Saudi journal of biological sciences
JID - 101543796
PMC - PMC8958322
OTO - NOTNLM
OT  - Anchomanes difformis
OT  - Antioxidants
OT  - Diabetes mellitus
OT  - Endogenous antioxidant enzymes
OT  - Free radicals
OT  - Hyperglycaemia
OT  - Male reproductive dysfunction
OT  - Oxidative stress
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2022/04/01 06:00
MHDA- 2022/04/01 06:01
PMCR- 2022/03/12
CRDT- 2022/03/31 05:24
PHST- 2021/11/05 00:00 [received]
PHST- 2022/02/02 00:00 [revised]
PHST- 2022/03/07 00:00 [accepted]
PHST- 2022/03/31 05:24 [entrez]
PHST- 2022/04/01 06:00 [pubmed]
PHST- 2022/04/01 06:01 [medline]
PHST- 2022/03/12 00:00 [pmc-release]
AID - S1319-562X(22)00161-9 [pii]
AID - 10.1016/j.sjbs.2022.03.015 [doi]
PST - ppublish
SO  - Saudi J Biol Sci. 2022 May;29(5):3122-3132. doi: 10.1016/j.sjbs.2022.03.015. Epub 
      2022 Mar 12.