PMID- 35356144
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220401
IS  - 2288-176X (Print)
IS  - 2288-1778 (Electronic)
IS  - 2288-176X (Linking)
VI  - 18
IP  - 1
DP  - 2022 Feb
TI  - Treadmill exercise ameliorates ethanol with lipopolysaccharide and carbon 
      tetrachloride-mediated liver injury in mice.
PG  - 28-33
LID - 10.12965/jer.2244002.001 [doi]
AB  - We reported that application of ethanol with lipopolysaccharide (LPS) and carbon 
      tetrachloride (CCl(4)) enhanced alanine aminotransferase (ALT) and aspartate 
      aminotransferase (AST) level. In the current experiment, the protective effect of 
      treadmill running on liver injury caused by ethanol with LPS and CCl(4) in mice 
      was studied. Liver injury severity was determined by measuring ALT and AST level 
      in the blood. Terminal deoxynucleotidyl transferase-mediated dUTP nick end 
      labeling (TUNEL) staining, immunohistochemistry for caspase-3, and Western 
      blotting for Bcl-2-associated X protein (Bax) and B-cell lymphoma 2 (Bcl-2) were 
      performed to indicate hepatocyte apoptosis. In addition, to understand the 
      mechanism, 5'-adenosine monophosphate-activated protein kinase (AMPK) 
      phosphorylation was studied by Western blotting. Treadmill exercise ameliorated 
      ethanol with LPS and CCl(4)-mediated elevation of ALT and AST level. Treadmill 
      exercise suppressed ethanol with LPS and CCl(4)-mediated elevation of the 
      TUNEL-positive cell number and cleaved caspase-3 expression. Treadmill exercise 
      suppressed ethanol with LPS and CCl(4)-mediated elevation of Bax expression and 
      increased Bcl-2 expression suppressed by application of ethanol with LPS and 
      CCl(4). Treadmill exercise enhanced AMPK phosphorylation which was suppressed by 
      application of ethanol with LPS and CCl(4). Treadmill exercise has the effect of 
      reducing liver damage caused by alcohol and or drug addiction.
CI  - Copyright (c) 2022 Korean Society of Exercise Rehabilitation.
FAU - Kim, Sang-Hoon
AU  - Kim SH
AD  - Department of Sport & Health Sciences, College of Art & Culture, Sangmyung 
      University, Seoul, Korea.
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Ko, Il-Gyu
AU  - Ko IG
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Jin, Jun-Jang
AU  - Jin JJ
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Hwang, Lakkyong
AU  - Hwang L
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Yoon, Hye-Sun
AU  - Yoon HS
AD  - Department of Pediatrics, Eulji Hospital, Eulji University School of Medicine, 
      Seoul, Korea.
FAU - Baek, Seung-Soo
AU  - Baek SS
AUID- ORCID: 0000-0002-1340-2098
AD  - Department of Sport & Health Sciences, College of Art & Culture, Sangmyung 
      University, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20220224
PL  - Korea (South)
TA  - J Exerc Rehabil
JT  - Journal of exercise rehabilitation
JID - 101615171
PMC - PMC8934608
OTO - NOTNLM
OT  - Carbon tetrachloride
OT  - Ethanol
OT  - Lipopolysaccharide
OT  - Liver
OT  - Treadmill exercise
COIS- CONFLICT OF INTEREST No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2022/04/01 06:00
MHDA- 2022/04/01 06:01
PMCR- 2022/02/24
CRDT- 2022/03/31 05:27
PHST- 2021/12/01 00:00 [received]
PHST- 2022/01/02 00:00 [accepted]
PHST- 2022/03/31 05:27 [entrez]
PHST- 2022/04/01 06:00 [pubmed]
PHST- 2022/04/01 06:01 [medline]
PHST- 2022/02/24 00:00 [pmc-release]
AID - jer-18-1-28 [pii]
AID - 10.12965/jer.2244002.001 [doi]
PST - epublish
SO  - J Exerc Rehabil. 2022 Feb 24;18(1):28-33. doi: 10.12965/jer.2244002.001. 
      eCollection 2022 Feb.