PMID- 35356702
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220401
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 15
DP  - 2022
TI  - Influence of Carotid Intima-Media Thickness Levels at Bifurcation on Short-Term 
      Functional Outcomes Among Non-Cardiogenic Ischemic Stroke Patients with and 
      without Type 2 Diabetes Mellitus.
PG  - 897-906
LID - 10.2147/DMSO.S351679 [doi]
AB  - PURPOSE: The intima-media thickness (IMT) is broadly reported to have 
      relationships with non-cardiogenic ischemic stroke and with diabetes. But how 
      does IMT affect the short-term prognosis of stroke seems unknown yet. We 
      investigated the influence of the intima-media thickness at carotid bifurcation 
      (IMTbif) on short-term functional outcomes among non-cardiogenic ischemic stroke 
      patients with and without type 2 diabetes mellitus (T2DM). PATIENTS AND METHODS: 
      A total of 314 patients with non-cardiogenic ischemic stroke (122 with T2DM and 
      192 without diabetes) were included in this retrospective study. Poor functional 
      outcome was defined as a modified Rankin Scale (mRS) > 2 at 3 months after stroke 
      onset. Group comparisons were done in favorable and poor outcome groups. Linear 
      regression analysis was utilized to verify the associations between IMTbif and 
      mRS in subgroups with and without diabetes, respectively. RESULTS: The median 
      IMTbif of total patients was 1.40mm. Patients with poor outcomes were 
      significantly older, had higher National Institutes of Health Stroke Scale 
      (NIHSS) scores, lower haemoglobin, higher fasting glucose and higher systolic 
      blood pressure values. Their IMTbif levels were also markedly higher. Among 122 
      included stroke patients with T2DM, IMTbif levels and NIHSS were independently 
      associated with functional outcomes at 3 months, whereas there was no significant 
      association between IMTbif levels and short-term functional outcomes among 
      patients without diabetes. CONCLUSION: The IMTbif levels were significantly 
      associated with 3-month functional outcomes in non-cardiogenic ischemic stroke 
      patients with T2DM. The ultrasound detection of the IMTbif therefore suggests a 
      prognostic value among patients with stroke and T2DM.
CI  - (c) 2022 Guo et al.
FAU - Guo, Xiao-Jing
AU  - Guo XJ
AD  - Department of Neurology, The Affiliated Suzhou Hospital of Nanjing Medical 
      University, Suzhou, Jiangsu, People's Republic of China.
FAU - Wu, Mian
AU  - Wu M
AD  - Department of Endocrinology and Metabolism, The Affiliated Suzhou Hospital of 
      Nanjing Medical University, Suzhou, Jiangsu, People's Republic of China.
FAU - Pei, Shao-Fang
AU  - Pei SF
AD  - Department of Neurology, The Affiliated Suzhou Hospital of Nanjing Medical 
      University, Suzhou, Jiangsu, People's Republic of China.
FAU - Xie, Ping
AU  - Xie P
AD  - Department of Ultrasonography, The Affiliated Suzhou Hospital of Nanjing Medical 
      University, Suzhou, Jiangsu, People's Republic of China.
FAU - Wu, Min-Ya
AU  - Wu MY
AUID- ORCID: 0000-0002-5335-1889
AD  - Department of Neurology, The Affiliated Suzhou Hospital of Nanjing Medical 
      University, Suzhou, Jiangsu, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20220323
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC8958197
OTO - NOTNLM
OT  - carotid bifurcation
OT  - cerebrovascular disease
OT  - prognosis
OT  - type 2 diabetes
COIS- Xiao-Jing Guo and Mian Wu are co-first authors for this study. The authors report 
      no conflicts of interest in this work.
EDAT- 2022/04/01 06:00
MHDA- 2022/04/01 06:01
PMCR- 2022/03/23
CRDT- 2022/03/31 05:35
PHST- 2021/12/14 00:00 [received]
PHST- 2022/03/10 00:00 [accepted]
PHST- 2022/03/31 05:35 [entrez]
PHST- 2022/04/01 06:00 [pubmed]
PHST- 2022/04/01 06:01 [medline]
PHST- 2022/03/23 00:00 [pmc-release]
AID - 351679 [pii]
AID - 10.2147/DMSO.S351679 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2022 Mar 23;15:897-906. doi: 10.2147/DMSO.S351679. 
      eCollection 2022.