PMID- 35356737
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220401
IS  - 2296-861X (Print)
IS  - 2296-861X (Electronic)
IS  - 2296-861X (Linking)
VI  - 9
DP  - 2022
TI  - Exercise Interventions Combined With Dietary Supplements in Type 2 Diabetes 
      Mellitus Patients-A Systematic Review of Relevant Health Outcomes.
PG  - 817724
LID - 10.3389/fnut.2022.817724 [doi]
LID - 817724
AB  - INTRODUCTION: Physical training can improve several health variables in patients 
      with type 2 diabetes mellitus (T2DM). A growing body of studies also finds a 
      positive influence of dietary supplement (DS) intake. The aim of this review is 
      to shed light on the possible effects of training interventions combined with DS 
      intake in T2DM patients. METHODS: A systematic search was performed following the 
      Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 
      guidelines in the PubMed and BISp Surf databases. Inclusion criteria were defined 
      using the Patient-Intervention-Comparison-Outcome (PICO) scheme. The 
      Physiotherapy Evidence Database (PEDro) scale was used for quality assessment and 
      risk of bias analysis. RESULTS: Ten controlled interventional studies with a 
      total number of 643 subjects met the inclusion criteria. These studies 
      investigated the effects of (a) vitamin D (VD), (b) VD + whey protein, (c) 
      polyphenol containing antioxidant capsules, (d) creatine, (e) L-arginine, (f) 
      leucine-rich amino acids, and (g) broccoli sprouts powder. Eight studies 
      investigated effects on one or more of the following health outcomes: body mass 
      index, fat mass, insulin resistance, glycemic control, lipid profile, oxidative 
      stress/antioxidative capacity and/or inflammatory markers/molecules. Five of the 
      studies show clear superior effects of physical training combined with DS intake 
      (supplements a, b, c, e) on some of these variables compared with training only. 
      However, one study indicates that VD intake might attenuate the training effects 
      on triglyceride levels. Another study found that training + VD + whey protein 
      intake increased tumor necrosis factor-alpha levels in T2DM patients. The effects of 
      training combined with DS intake on renal function (supplement d) or incretin 
      metabolism (supplement a) were investigated in two further studies. These studies 
      do not show any additional effects of DS intake. The quality of the majority of 
      the studies was high. CONCLUSION: DS intake can potentially increase the benefits 
      of physical training for specific health outcomes in T2DM patients. However, 
      negative effects can also be observed. Possible cellular and molecular mechanisms 
      behind potential synergistic or divergent effects of exercise training and DS use 
      in T2DM should be explored in detail in future studies for the development of 
      safe recommendations.
CI  - Copyright (c) 2022 Meuffels, Isenmann, Strube, Lesch, Oberste and Brinkmann.
FAU - Meuffels, Frederike Maria
AU  - Meuffels FM
AD  - Department of Preventive and Rehabilitative Sport Medicine, Institute of 
      Cardiovascular Research and Sport Medicine, German Sport University Cologne, 
      Cologne, Germany.
AD  - IST University of Applied Sciences, Dusseldorf, Germany.
FAU - Isenmann, Eduard
AU  - Isenmann E
AD  - IST University of Applied Sciences, Dusseldorf, Germany.
AD  - Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular 
      Research and Sport Medicine, German Sport University Cologne, Cologne, Germany.
FAU - Strube, Malte
AU  - Strube M
AD  - Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular 
      Research and Sport Medicine, German Sport University Cologne, Cologne, Germany.
FAU - Lesch, Alessio
AU  - Lesch A
AD  - Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular 
      Research and Sport Medicine, German Sport University Cologne, Cologne, Germany.
FAU - Oberste, Max
AU  - Oberste M
AD  - Institute of Medical Statistics and Computational Biology (IMSB), Faculty of 
      Medicine and University Hospital Cologne, University of Cologne, Cologne, 
      Germany.
FAU - Brinkmann, Christian
AU  - Brinkmann C
AD  - Department of Preventive and Rehabilitative Sport Medicine, Institute of 
      Cardiovascular Research and Sport Medicine, German Sport University Cologne, 
      Cologne, Germany.
AD  - IST University of Applied Sciences, Dusseldorf, Germany.
LA  - eng
PT  - Systematic Review
DEP - 20220309
PL  - Switzerland
TA  - Front Nutr
JT  - Frontiers in nutrition
JID - 101642264
PMC - PMC8959696
OTO - NOTNLM
OT  - diabetes mellitus
OT  - dietary supplements
OT  - exercise
OT  - physical activity
OT  - sports
OT  - training
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/04/01 06:00
MHDA- 2022/04/01 06:01
PMCR- 2022/01/01
CRDT- 2022/03/31 05:36
PHST- 2021/11/18 00:00 [received]
PHST- 2022/01/25 00:00 [accepted]
PHST- 2022/03/31 05:36 [entrez]
PHST- 2022/04/01 06:00 [pubmed]
PHST- 2022/04/01 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnut.2022.817724 [doi]
PST - epublish
SO  - Front Nutr. 2022 Mar 9;9:817724. doi: 10.3389/fnut.2022.817724. eCollection 2022.