PMID- 35360021 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220402 IS - 2297-055X (Print) IS - 2297-055X (Electronic) IS - 2297-055X (Linking) VI - 9 DP - 2022 TI - Comorbidity of Type 2 Diabetes Mellitus and Depression: Clinical Evidence and Rationale for the Exacerbation of Cardiovascular Disease. PG - 861110 LID - 10.3389/fcvm.2022.861110 [doi] LID - 861110 AB - Depression is a common comorbidity of type 2 diabetes mellitus (T2DM). T2DM with comorbid depression increases the risk of cardiovascular events and death. Depression and T2DM and its macrovascular complications exhibited a two-way relationship. Regarding treatment, antidepressants can affect the development of T2DM and cardiovascular events, and hypoglycemic drugs can also affect the development of depression and cardiovascular events. The combination of these two types of medications may increase the risk of the first myocardial infarction. Herein, we review the latest research progress in the exacerbation of cardiovascular disease due to T2DM with comorbid depression and provide a rationale and an outlook for the prevention and treatment of cardiovascular disease in T2DM with comorbid depression. CI - Copyright (c) 2022 Zhu, Li, Luo, Cui, Liu and Liu. FAU - Zhu, Mengmeng AU - Zhu M AD - National Clinical Research Centre for Chinese Medicine Cardiology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China. FAU - Li, Yiwen AU - Li Y AD - National Clinical Research Centre for Chinese Medicine Cardiology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China. FAU - Luo, Binyu AU - Luo B AD - National Clinical Research Centre for Chinese Medicine Cardiology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China. FAU - Cui, Jing AU - Cui J AD - National Clinical Research Centre for Chinese Medicine Cardiology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China. FAU - Liu, Yanfei AU - Liu Y AD - Second Department of Geriatrics, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China. FAU - Liu, Yue AU - Liu Y AD - National Clinical Research Centre for Chinese Medicine Cardiology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China. LA - eng PT - Journal Article PT - Review DEP - 20220310 PL - Switzerland TA - Front Cardiovasc Med JT - Frontiers in cardiovascular medicine JID - 101653388 PMC - PMC8960118 OTO - NOTNLM OT - cardiovascular disease OT - clinical evidence OT - depression OT - outlook OT - type 2 diabetes mellitus (T2DM) COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2022/04/02 06:00 MHDA- 2022/04/02 06:01 PMCR- 2022/01/01 CRDT- 2022/04/01 05:16 PHST- 2022/01/24 00:00 [received] PHST- 2022/02/07 00:00 [accepted] PHST- 2022/04/01 05:16 [entrez] PHST- 2022/04/02 06:00 [pubmed] PHST- 2022/04/02 06:01 [medline] PHST- 2022/01/01 00:00 [pmc-release] AID - 10.3389/fcvm.2022.861110 [doi] PST - epublish SO - Front Cardiovasc Med. 2022 Mar 10;9:861110. doi: 10.3389/fcvm.2022.861110. eCollection 2022.