PMID- 35361027
OWN - NLM
STAT- MEDLINE
DCOM- 20220801
LR  - 20220815
IS  - 1477-0377 (Electronic)
IS  - 1358-863X (Linking)
VI  - 27
IP  - 4
DP  - 2022 Aug
TI  - Elevated serum homocysteine levels are associated with the development of chronic 
      venous ulcers.
PG  - 358-364
LID - 10.1177/1358863X221080486 [doi]
AB  - INTRODUCTION: Venous ulceration is a multifactorial disease, and whether 
      hyperhomocysteinemia (HHcy) promotes deterioration from primary varicose veins to 
      venous ulcers remains unproven. METHODS: This study retrospectively analyzed 
      clinical data from 717 patients to investigate the potential correlation between 
      HHcy and primary varicose veins ulcer formation, including 611 patients without 
      ulcers (control group) and 106 with ulcers (case group). RESULTS: In this study, 
      46.2% (49/106) of patients in the case group and 17.5% (107/611, p < 0.001) in 
      the control group suffered from HHcy. Multivariate logistic analysis revealed 
      that HHcy was closely associated with the incidence of venous ulceration in 
      patients with primary varicose veins (p < 0.001). Propensity score matching 
      created 101 matched pairs of patients with and without ulcers, and the analysis 
      pointed to a potential link between HHcy and ulcer formation in the context of 
      primary varicose veins (p < 0.001). Additional experiments showed that HHcy could 
      induce endothelial dysfunction and phenotypic switching of vascular smooth muscle 
      cells. CONCLUSION: Both clinical and experimental findings implicated HHcy as a 
      key factor in the development of venous ulceration. Further research is needed to 
      appraise the effectiveness of HHcy-lowering therapy in the prevention of venous 
      ulcers in patients with varicose veins.
FAU - Guo, Zhenyu
AU  - Guo Z
AD  - Department of Vascular Surgery, Qingpu Branch of Zhongshan Hospital, Fudan 
      University, Shanghai, China.
FAU - Li, Xu
AU  - Li X
AD  - Department of Vascular Surgery, Qingpu Branch of Zhongshan Hospital, Fudan 
      University, Shanghai, China.
FAU - Wang, Tao
AU  - Wang T
AD  - Department of Vascular Surgery, Qingpu Branch of Zhongshan Hospital, Fudan 
      University, Shanghai, China.
FAU - Yang, Xiaohu
AU  - Yang X
AD  - Department of Vascular Surgery, Qingpu Branch of Zhongshan Hospital, Fudan 
      University, Shanghai, China.
FAU - Fan, Longhua
AU  - Fan L
AUID- ORCID: 0000-0002-2252-437X
AD  - Department of Vascular Surgery, Qingpu Branch of Zhongshan Hospital, Fudan 
      University, Shanghai, China.
AD  - Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220331
PL  - England
TA  - Vasc Med
JT  - Vascular medicine (London, England)
JID - 9610930
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Homocysteine
MH  - Humans
MH  - Retrospective Studies
MH  - Ulcer/complications
MH  - *Varicose Ulcer/diagnosis/epidemiology
MH  - *Varicose Veins/complications
OTO - NOTNLM
OT  - hyperhomocysteinemia
OT  - varicose veins
OT  - venous ulceration
EDAT- 2022/04/02 06:00
MHDA- 2022/08/02 06:00
CRDT- 2022/04/01 05:30
PHST- 2022/04/02 06:00 [pubmed]
PHST- 2022/08/02 06:00 [medline]
PHST- 2022/04/01 05:30 [entrez]
AID - 10.1177/1358863X221080486 [doi]
PST - ppublish
SO  - Vasc Med. 2022 Aug;27(4):358-364. doi: 10.1177/1358863X221080486. Epub 2022 Mar 
      31.