PMID- 35361173
OWN - NLM
STAT- MEDLINE
DCOM- 20220404
LR  - 20220405
IS  - 1471-2474 (Electronic)
IS  - 1471-2474 (Linking)
VI  - 23
IP  - 1
DP  - 2022 Mar 31
TI  - Minimal clinically important difference for improvement in six-minute walk test 
      in persons with knee osteoarthritis after total knee arthroplasty.
PG  - 307
LID - 10.1186/s12891-022-05262-4 [doi]
LID - 307
AB  - BACKGROUND: The interpretability of the six-minute walk test (6MWT) in 
      individuals with knee osteoarthritis (OA) is unclear. We aimed to determine the 
      minimal clinically important difference (MCID) for improvement in 6MWT in persons 
      with knee OA at 12 months after total knee arthroplasty (TKA), and if it differed 
      by baseline walking ability. METHODS: Participants with knee OA were assessed 1 
      month pre- and 12 months post-TKA, including completion of 6MWT. At 12 months, 
      participant-perceived change in walking ability was assessed on an 8-point Likert 
      scale ranging from "extremely worse" to "extremely better". Using logistic 
      regression, ROC curves examined the ability of change in 6MWT distance to 
      discriminate those who perceived walking was improved. MCID was selected overall 
      and then by quartile of baseline 6MWT distance using the Youden method. RESULTS: 
      Two hundred seventy-eight participants were included: mean age 67 years (SD 8.5), 
      65.5% female, mean pre-TKA 6MWT distance 323.1 (SD 104.7) m, and mean 12-mo 6MWT 
      distance 396.0 (SD 111.9) m. The overall MCID was 74.3 m (AUC 0.65). Acceptable 
      model discrimination (AUC > 0.70) was achieved for individuals in the lowest 
      quartiles of baseline 6MWT distance: Quartile 1: MCID 88.63 m (AUC 0.73); 
      Quartile 2: MCID 84.47 m (AUC 0.72). CONCLUSIONS: In persons with knee OA 
      12 months post-TKA, 6MWT MCID is dependent on baseline walking ability. Poor 
      model discrimination for those in the highest (best) quartiles of baseline 
      walking ability raise questions about 6MWT use across the full spectrum of 
      walking ability. Further research is needed to better understand use of 6MWT as a 
      performance-based measure of physical function for persons with knee OA.
CI  - (c) 2022. The Author(s).
FAU - King, Lauren K
AU  - King LK
AD  - Department of Medicine, University of Toronto, Toronto, ON, M5S 3H2, Canada. 
      l.king@mail.utoronto.ca.
AD  - Women's College Research Institute, Women's College Hospital, 6307 - 76 Grenville 
      Street, 6th Floor, Toronto, ON, M5S 1B2, Canada. l.king@mail.utoronto.ca.
FAU - Hawker, Gillian A
AU  - Hawker GA
AD  - Department of Medicine, University of Toronto, Toronto, ON, M5S 3H2, Canada.
AD  - Women's College Research Institute, Women's College Hospital, 6307 - 76 Grenville 
      Street, 6th Floor, Toronto, ON, M5S 1B2, Canada.
FAU - Stanaitis, Ian
AU  - Stanaitis I
AD  - Women's College Research Institute, Women's College Hospital, 6307 - 76 Grenville 
      Street, 6th Floor, Toronto, ON, M5S 1B2, Canada.
FAU - Woodhouse, Linda
AU  - Woodhouse L
AD  - Department of Physical Therapy, Faculty of Rehabilitation Medicine, University of 
      Alberta, Edmonton, AB, T6G 2G4, Canada.
FAU - Jones, C Allyson
AU  - Jones CA
AD  - Department of Physical Therapy, Faculty of Rehabilitation Medicine, University of 
      Alberta, Edmonton, AB, T6G 2G4, Canada.
FAU - Waugh, Esther J
AU  - Waugh EJ
AD  - Women's College Research Institute, Women's College Hospital, 6307 - 76 Grenville 
      Street, 6th Floor, Toronto, ON, M5S 1B2, Canada.
AD  - Department of Physical Therapy, University of Toronto, Toronto, ON, M5G 1V7, 
      Canada.
LA  - eng
PT  - Journal Article
DEP - 20220331
PL  - England
TA  - BMC Musculoskelet Disord
JT  - BMC musculoskeletal disorders
JID - 100968565
SB  - IM
MH  - Aged
MH  - *Arthroplasty, Replacement, Knee
MH  - Female
MH  - Humans
MH  - Male
MH  - Minimal Clinically Important Difference
MH  - *Osteoarthritis, Knee/diagnosis/surgery
MH  - Walk Test
MH  - Walking
PMC - PMC8969367
OTO - NOTNLM
OT  - Knee osteoarthritis
OT  - Minimal clinically important difference
OT  - Six-minute walk test
OT  - Total knee arthroplasty
COIS- GAH has received research support as the Sir John and Lady Eaton Professor and 
      Chair of Medicine, Department of Medicine, University of Toronto; all other 
      authors declare no other relationships or activities that could appear to have 
      influenced the submitted work.
EDAT- 2022/04/02 06:00
MHDA- 2022/04/05 06:00
PMCR- 2022/03/31
CRDT- 2022/04/01 05:31
PHST- 2021/10/04 00:00 [received]
PHST- 2022/03/21 00:00 [accepted]
PHST- 2022/04/01 05:31 [entrez]
PHST- 2022/04/02 06:00 [pubmed]
PHST- 2022/04/05 06:00 [medline]
PHST- 2022/03/31 00:00 [pmc-release]
AID - 10.1186/s12891-022-05262-4 [pii]
AID - 5262 [pii]
AID - 10.1186/s12891-022-05262-4 [doi]
PST - epublish
SO  - BMC Musculoskelet Disord. 2022 Mar 31;23(1):307. doi: 10.1186/s12891-022-05262-4.