PMID- 35361419 OWN - NLM STAT- MEDLINE DCOM- 20220404 LR - 20220405 IS - 1873-4324 (Electronic) IS - 0003-2670 (Print) IS - 0003-2670 (Linking) VI - 1203 DP - 2022 Apr 22 TI - Development of a solid phase microextraction gas chromatography tandem mass spectrometry methodology for the analysis of sixty personal care products in hydroalcoholic gels - hand sanitizers - in the context of COVID-19 pandemic. PG - 339650 LID - S0003-2670(22)00221-5 [pii] LID - 10.1016/j.aca.2022.339650 [doi] AB - Because of the coronavirus pandemic, hydroalcoholic gels have become essential products to prevent the spread of COVID-19. This research aims to develop a simple, fast and sustainable microextraction methodology followed by gas chromatography tandem mass spectrometry (GC-MS/MS) to analyze simultaneously 60 personal care products (PCPs) including fragrances allergens, synthetic musks, preservatives and plasticizers in hand sanitizers. Micro-matrix-solid-phase dispersion (muMSPD) and solid-phase microextraction (SPME) were compared with the aim of obtaining high sensitivity and sample throughput. SPME demonstrated higher efficiency being selected as sample treatment. Different dilutions of the sample in ultrapure water were assessed to achieve high sensitivity but, at the same time, to avoid or minimize matrix effect. The most critical parameters affecting SPME (fibre coating, extraction mode and temperature) were optimized by design of experiments (DOE). The method was successfully validated in terms of linearity, precision and accuracy, obtaining recovery values between 80 and 112% for most compounds with relative standard deviation (RSD) values lower than 10%. External calibration using standards prepared in ultrapure water demonstrated suitability due to the absence of matrix effect. Finally, the simple, fast and high throughput method was applied to the analysis of real hydroalcoholic gel samples. Among the 60 target compounds, 39 of them were found, highlighting the high number of fragrance allergens, at concentrations ranging between 0.01 and 217 mug g(-1). Most of the samples were not correctly labelled attending cosmetic Regulation (EU) No 1223/2009, and none of them followed the World Health Organization (WHO) recommendation for hand sanitizers formulation. CI - Copyright (c) 2022 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Vazquez, Lua AU - Vazquez L AD - CRETUS, Department of Analytical Chemistry, Nutrition and Food Science, Universidade de Santiago de Compostela, E-15782, Santiago de Compostela, Spain. FAU - Celeiro, Maria AU - Celeiro M AD - CRETUS, Department of Analytical Chemistry, Nutrition and Food Science, Universidade de Santiago de Compostela, E-15782, Santiago de Compostela, Spain. FAU - Castineira-Landeira, Ana AU - Castineira-Landeira A AD - CRETUS, Department of Analytical Chemistry, Nutrition and Food Science, Universidade de Santiago de Compostela, E-15782, Santiago de Compostela, Spain. FAU - Dagnac, Thierry AU - Dagnac T AD - Galician Agency for Food Quality - Agronomic Research Centre (AGACAL-CIAM) - Unit of Organic Contaminants, Apartado 10, E-15080, A Coruna, Spain. FAU - Llompart, Maria AU - Llompart M AD - CRETUS, Department of Analytical Chemistry, Nutrition and Food Science, Universidade de Santiago de Compostela, E-15782, Santiago de Compostela, Spain. Electronic address: maria.llompart@usc.es. LA - eng PT - Journal Article DEP - 20220308 PL - Netherlands TA - Anal Chim Acta JT - Analytica chimica acta JID - 0370534 RN - 0 (Cosmetics) RN - 0 (Gels) RN - 0 (Hand Sanitizers) SB - IM MH - *COVID-19 MH - *Cosmetics/analysis MH - Gas Chromatography-Mass Spectrometry/methods MH - Gels MH - *Hand Sanitizers/analysis MH - Humans MH - Pandemics MH - Solid Phase Microextraction/methods MH - Tandem Mass Spectrometry/methods PMC - PMC8902396 OTO - NOTNLM OT - Experimental design OT - Fragrance allergens OT - Gas chromatography-tandem mass spectrometry OT - Hydroalcoholic gels OT - Personal care products OT - Solid-phase microextraction COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/04/02 06:00 MHDA- 2022/04/05 06:00 PMCR- 2022/03/08 CRDT- 2022/04/01 05:32 PHST- 2021/12/15 00:00 [received] PHST- 2022/02/10 00:00 [revised] PHST- 2022/02/22 00:00 [accepted] PHST- 2022/04/01 05:32 [entrez] PHST- 2022/04/02 06:00 [pubmed] PHST- 2022/04/05 06:00 [medline] PHST- 2022/03/08 00:00 [pmc-release] AID - S0003-2670(22)00221-5 [pii] AID - 339650 [pii] AID - 10.1016/j.aca.2022.339650 [doi] PST - ppublish SO - Anal Chim Acta. 2022 Apr 22;1203:339650. doi: 10.1016/j.aca.2022.339650. Epub 2022 Mar 8.