PMID- 35361540
OWN - NLM
STAT- MEDLINE
DCOM- 20220608
LR  - 20230602
IS  - 1878-7533 (Electronic)
IS  - 1550-7289 (Print)
IS  - 1550-7289 (Linking)
VI  - 18
IP  - 6
DP  - 2022 Jun
TI  - Measures of glucose homeostasis during and after duodenal exclusion using a 
      duodenal-jejunal bypass liner in a normoglycemic, nonobese canine model.
PG  - 694-702
LID - S1550-7289(22)00082-X [pii]
LID - 10.1016/j.soard.2022.02.012 [doi]
AB  - BACKGROUND: Discovering the role duodenal exclusion plays in weight loss and 
      resolution of type 2 diabetes (T2D) may help refine the surgical and nonsurgical 
      treatment of obesity and T2D. OBJECTIVES: To assess changes in glucose 
      homeostasis due to duodenal exclusion using a duodenal-jejunal bypass liner 
      (DJBL) in a nonobese canine model. SETTING: Academic laboratory setting. METHODS: 
      An intravenous glucose tolerance test (IVGTT), and a mixed-meal tolerance test 
      (MMTT) at baseline, 1, and 6 weeks post DJBL implantation (I1 and I6, 
      respectively), and 1 and 6 weeks post DJBL removal (R1 and R6, respectively) were 
      done in canines (n = 7) fed a normal chow diet. RESULTS: Placement of the DJBL 
      induced weight loss that was maintained until 4 weeks post removal (R4), despite 
      normal food intake. Total bile acids (TBA) and glucagon-like peptide-1 (GLP-1) 
      during the MMTT were significantly increased at I1 and were associated with 
      increased lactate and free fatty acids. Hypoglycemia counter-regulation was 
      blunted during the IVGTT at I1 and I6, returning to baseline at R1. While there 
      were no changes to insulin sensitivity during the experiment, glucose tolerance 
      was significantly increased following the removal of the DJBL at R1. CONCLUSION: 
      These data show that in a normoglycemic, nonobese canine model, duodenal 
      exclusion induces energy intake-independent weight loss and negative metabolic 
      effects that are reversed following re-exposure of the small intestine to 
      nutrients.
CI  - Copyright (c) 2022 American Society for Bariatric Surgery. Published by Elsevier 
      Inc. All rights reserved.
FAU - Paszkiewicz, Rebecca L
AU  - Paszkiewicz RL
AD  - Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los 
      Angeles, California. Electronic address: rpaszkiewicz@mednet.ucla.edu.
FAU - Burch, Miguel A
AU  - Burch MA
AD  - Minimally Invasive and GI Surgery, Cedars-Sinai Medical Center, Los Angeles, 
      California.
FAU - Asare Bediako, Isaac
AU  - Asare Bediako I
AD  - Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los 
      Angeles, California.
FAU - Mkrtchyan, Hasmik
AU  - Mkrtchyan H
AD  - Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los 
      Angeles, California.
FAU - Piccinini, Francesca
AU  - Piccinini F
AD  - Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los 
      Angeles, California.
FAU - Ader, Marilyn
AU  - Ader M
AD  - Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los 
      Angeles, California.
FAU - Bresee, Catherine
AU  - Bresee C
AD  - Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los 
      Angeles, California.
FAU - Bergman, Richard N
AU  - Bergman RN
AD  - Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los 
      Angeles, California.
LA  - eng
GR  - R01 DK027619/DK/NIDDK NIH HHS/United States
GR  - R01 DK029867/DK/NIDDK NIH HHS/United States
PT  - Journal Article
DEP - 20220222
PL  - United States
TA  - Surg Obes Relat Dis
JT  - Surgery for obesity and related diseases : official journal of the American 
      Society for Bariatric Surgery
JID - 101233161
RN  - 0 (Blood Glucose)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
CIN - Surg Obes Relat Dis. 2022 Jun;18(6):702-703. PMID: 35469756
MH  - Animals
MH  - *Bariatric Surgery
MH  - Blood Glucose/metabolism
MH  - *Diabetes Mellitus, Type 2/surgery
MH  - Dogs
MH  - Duodenum/metabolism/surgery
MH  - Glucose/metabolism
MH  - Homeostasis
MH  - Humans
MH  - Jejunum/metabolism/surgery
MH  - Treatment Outcome
MH  - Weight Loss
PMC - PMC10013877
MID - NIHMS1793498
OTO - NOTNLM
OT  - Bariatric surgery
OT  - Duodenal exclusion
OT  - Duodenal-jejunal bypass liner
OT  - Obesity
OT  - Type 2 diabetes
COIS- CONFLICTS OF INTEREST None.
EDAT- 2022/04/02 06:00
MHDA- 2022/06/09 06:00
PMCR- 2023/06/01
CRDT- 2022/04/01 05:34
PHST- 2021/06/09 00:00 [received]
PHST- 2022/01/31 00:00 [revised]
PHST- 2022/02/11 00:00 [accepted]
PHST- 2022/04/02 06:00 [pubmed]
PHST- 2022/06/09 06:00 [medline]
PHST- 2022/04/01 05:34 [entrez]
PHST- 2023/06/01 00:00 [pmc-release]
AID - S1550-7289(22)00082-X [pii]
AID - 10.1016/j.soard.2022.02.012 [doi]
PST - ppublish
SO  - Surg Obes Relat Dis. 2022 Jun;18(6):694-702. doi: 10.1016/j.soard.2022.02.012. 
      Epub 2022 Feb 22.