PMID- 35362373
OWN - NLM
STAT- MEDLINE
DCOM- 20220923
LR  - 20221010
IS  - 1875-5607 (Electronic)
IS  - 1389-5575 (Linking)
VI  - 22
IP  - 20
DP  - 2022
TI  - Advances and Applications of Metal-Organic Framework Nanomaterials as Oral 
      Delivery Carriers: A Review.
PG  - 2564-2580
LID - 10.2174/1389557522666220330152145 [doi]
AB  - Oral administration is a commonly used, safe, and patient-compliant method of 
      drug delivery. However, due to the multiple absorption barriers in the 
      gastrointestinal tract (GIT), the oral bioavailability of many drugs is low, 
      resulting in a limited range of applications for oral drug delivery. Nanodrug 
      delivery systems have unique advantages in overcoming the multiple barriers to 
      oral absorption and improving the oral bioavailability of encapsulated drugs. 
      Metal-organic frameworks (MOFs) are composed of metal ions and organic linkers 
      assembled by coordination chemistry. Unlike other nanomaterials, nanoscale 
      metal-organic frameworks (nano-MOFs, NMOFs) are increasingly popular for drug 
      delivery systems (DDSs) due to their tunable pore size and easily modified 
      surfaces. This paper summarizes the literature on MOFs in pharmaceutics included 
      in SCI for the past ten years. Then, the GIT structure and oral drug delivery 
      systems are reviewed, and the advantages, challenges, and solution strategies 
      possessed by oral drug delivery systems are discussed. Importantly, two major 
      classes of MOFs suitable for oral drug delivery systems are summarized, and 
      various representative MOFs as oral drug carriers are evaluated in the context of 
      oral drug delivery systems. Finally, the challenges faced by DDSs in the 
      development of MOFs, such as biostability, biosafety, and toxicity, are examined.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Li, Li
AU  - Li L
AD  - School of Pharmaceutical Sciences, Liaoning University, Shenyang, 110000, China.
AD  - Institute of Forensic Expertise, Liaoning University, Shenyang, 110000, China.
FAU - Qi, Zhaorui
AU  - Qi Z
AD  - School of Pharmaceutical Sciences, Liaoning University, Shenyang, 110000, China.
FAU - Han, Shasha
AU  - Han S
AD  - School of Pharmaceutical Sciences, Liaoning University, Shenyang, 110000, China.
FAU - Li, Xurui
AU  - Li X
AD  - School of Pharmaceutical Sciences, Liaoning University, Shenyang, 110000, China.
FAU - Liu, Bingmi
AU  - Liu B
AD  - School of Pharmaceutical Sciences, Liaoning University, Shenyang, 110000, China.
AD  - Institute of Forensic Expertise, Liaoning University, Shenyang, 110000, China.
FAU - Liu, Yu
AU  - Liu Y
AD  - School of Pharmaceutical Sciences, Liaoning University, Shenyang, 110000, China.
AD  - Institute of Forensic Expertise, Liaoning University, Shenyang, 110000, China.
LA  - eng
GR  - LJKZ0095/Liaoning Provincial Department of Education Program of China/
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Mini Rev Med Chem
JT  - Mini reviews in medicinal chemistry
JID - 101094212
RN  - 0 (Drug Carriers)
RN  - 0 (Metal-Organic Frameworks)
RN  - 0 (Metals)
SB  - IM
MH  - Drug Carriers/chemistry
MH  - Drug Delivery Systems
MH  - Humans
MH  - *Metal-Organic Frameworks/chemistry
MH  - Metals
MH  - *Nanostructures/chemistry
OTO - NOTNLM
OT  - Metal-organic frameworks
OT  - drug delivery
OT  - medical application of MOFs
OT  - nanocarriers
OT  - nanoparticles
OT  - oral administration
EDAT- 2022/04/02 06:00
MHDA- 2022/09/24 06:00
CRDT- 2022/04/01 08:38
PHST- 2021/12/31 00:00 [received]
PHST- 2022/01/27 00:00 [revised]
PHST- 2022/02/15 00:00 [accepted]
PHST- 2022/04/02 06:00 [pubmed]
PHST- 2022/09/24 06:00 [medline]
PHST- 2022/04/01 08:38 [entrez]
AID - MRMC-EPUB-122065 [pii]
AID - 10.2174/1389557522666220330152145 [doi]
PST - ppublish
SO  - Mini Rev Med Chem. 2022;22(20):2564-2580. doi: 10.2174/1389557522666220330152145.