PMID- 35362451
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220501
IS  - 2093-0879 (Print)
IS  - 2093-0887 (Electronic)
IS  - 2093-0879 (Linking)
VI  - 28
IP  - 2
DP  - 2022 Apr 30
TI  - Adverse Events Associated With Peroral Endoscopic Myotomy Affecting Extended 
      Hospital Stay: A Multi-center Retrospective Study in South Korea.
PG  - 247-254
LID - 10.5056/jnm21081 [doi]
AB  - BACKGROUND/AIMS: To analyze various adverse events (AEs) related to the peroral 
      endoscopic myotomy (POEM) procedure and to analyze whether these AEs are related 
      to an extended hospital stay. METHODS: Patients admitted for POEM for esophageal 
      motility disorders from August 2012 to February 2020 at 5 centers were 
      retrospectively collected. Length of hospital stay, AEs during or after the POEM 
      procedure were analyzed. RESULTS: Of the 328 patients, 63.1% did not have any 
      AEs, but 2.4% had major AEs, and 33.4% had minor AEs. Major AEs included mucosal 
      injury, bleeding, and hemothorax, accounting for 1.5%, 0.6%, and 0.3%, 
      respectively. Among the minor AEs, pneumoperitoneum was the most common 
      gas-related AEs. Among non-gas-related minor AEs, pneumonia was the most common 
      at 4.6%, followed by pain, fever, and pleural effusion. All major AEs had 
      meaningful delayed discharge and significantly extended hospital stay compared to 
      the no AEs group (median differences range 4.5-9.0 days). Among gas-related minor 
      AEs, except for 4 cases of emphysema, the extended hospital stay was meaningless. 
      All non-gas-related minor AEs was associated with a significant prolongation of 
      hospital stay compared to that in the no AEs group (median differences range 
      2.0-4.0 days). CONCLUSIONS: In conclusion, most gas-related minor AEs do not 
      significantly affect the patient's clinical course. However, subcutaneous 
      emphysema and minor non-gas related AEs such as pneumonia, pain, fever, and 
      pleural effusion can prolong the hospital stay, therefore careful observation is 
      required. Efforts will be made to reduce major AEs that significantly prolong 
      hospitalization.
FAU - Lee, Ju Yup
AU  - Lee JY
AD  - Department of Internal Medicine, Keimyung University School of Medicine, Daegu, 
      Korea.
FAU - Lim, Chul-Hyun
AU  - Lim CH
AD  - Division of Gastroenterology, Department of Internal Medicine, Eunpyeong St. 
      Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, 
      Korea.
FAU - Kim, Do Hoon
AU  - Kim DH
AD  - Department of Gastroenterology, University of Ulsan College of Medicine, Asan 
      Medical Center, Seoul, Korea.
FAU - Jung, Hwoon-Yong
AU  - Jung HY
AD  - Department of Gastroenterology, University of Ulsan College of Medicine, Asan 
      Medical Center, Seoul, Korea.
FAU - Youn, Young Hoon
AU  - Youn YH
AD  - Department of Gastroenterology, Internal Medicine, Gangnam Severance Hospital, 
      Yonsei University College of Medicine, Seoul, Korea.
FAU - Jung, Da Hyun
AU  - Jung DH
AD  - Department of Gastroenterology, Internal Medicine, Severance Hospital, Yonsei 
      University College of Medicine, Seoul, Korea.
FAU - Park, Jun Chul
AU  - Park JC
AD  - Department of Gastroenterology, Internal Medicine, Severance Hospital, Yonsei 
      University College of Medicine, Seoul, Korea.
FAU - Moon, Hee Seok
AU  - Moon HS
AD  - Department of Internal Medicine, Chungnam National University School of Medicine, 
      Daejeon, Korea.
FAU - Hong, Su Jin
AU  - Hong SJ
AD  - Digestive Disease Center and Research Institute, Department of Internal Medicine, 
      Soonchunhyang University College of Medicine, Bucheon, Gyeonggi-do, Korea.
CN  - Therapeutic Endoscopy and Instrument for Functional Gastrointestinal Disorders 
      Study Group Under the Korean Society of Neurogastroenterology and Motility
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - J Neurogastroenterol Motil
JT  - Journal of neurogastroenterology and motility
JID - 101530189
PMC - PMC8978124
OTO - NOTNLM
OT  - Achalasia
OT  - Adverse events
OT  - Endoscopic myotomy
OT  - Esophageal motility disorder
OT  - Hospital stay
COIS- Conflicts of interest: None.
EDAT- 2022/04/02 06:00
MHDA- 2022/04/02 06:01
PMCR- 2022/04/30
CRDT- 2022/04/01 08:38
PHST- 2021/04/20 00:00 [received]
PHST- 2021/07/17 00:00 [revised]
PHST- 2021/11/10 00:00 [accepted]
PHST- 2022/04/01 08:38 [entrez]
PHST- 2022/04/02 06:00 [pubmed]
PHST- 2022/04/02 06:01 [medline]
PHST- 2022/04/30 00:00 [pmc-release]
AID - jnm21081 [pii]
AID - jnm-28-2-247 [pii]
AID - 10.5056/jnm21081 [doi]
PST - ppublish
SO  - J Neurogastroenterol Motil. 2022 Apr 30;28(2):247-254. doi: 10.5056/jnm21081.