PMID- 35363544
OWN - NLM
STAT- MEDLINE
DCOM- 20220405
LR  - 20220610
IS  - 2470-9468 (Electronic)
IS  - 2470-9468 (Linking)
VI  - 7
IP  - 70
DP  - 2022 Apr
TI  - Human dendritic cells in cancer.
PG  - eabm9409
LID - 10.1126/sciimmunol.abm9409 [doi]
AB  - Dendritic cells (DCs) are professional antigen-presenting cells, orchestrating 
      innate and adaptive immunity during infections, autoimmune diseases, and 
      malignancies. Since the discovery of DCs almost 50 years ago, our understanding 
      of their biology in humans has increased substantially. Here, we review both 
      antitumor and tolerogenic DC responses in cancer and discuss lineage-specific 
      contributions by their functionally specialized subsets, including the 
      conventional DC (cDC) subsets cDC1 and cDC2, the newly described DC3, and the 
      plasmacytoid DCs (pDCs), focusing on the human setting. In addition, we review 
      the lineage-unrestricted "mature DCs enriched in immunoregulatory molecules" 
      (mregDC) state recently described across different human tumors.
FAU - Kvedaraite, Egle
AU  - Kvedaraite E
AUID- ORCID: 0000-0001-5308-092X
AD  - Childhood Cancer Research Unit, Department of Women's and Children's Health, 
      Karolinska Institutet, Stockholm, Sweden.
AD  - Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska 
      Institutet, Karolinska University Hospital, Stockholm, Sweden.
AD  - Department of Clinical Pathology and Cancer Diagnostics, Karolinska University 
      Hospital, Stockholm, Sweden.
FAU - Ginhoux, Florent
AU  - Ginhoux F
AUID- ORCID: 0000-0002-2857-7755
AD  - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research 
      (A*STAR), BIOPOLIS, Singapore, Singapore.
AD  - Inserm U1015, Gustave Roussy, Villejuif 94800, France.
AD  - Shanghai Institute of Immunology, Shanghai JiaoTong University School of 
      Medicine, Shanghai, China.
AD  - Translational Immunology Institute, SingHealth Duke-NUS Academic Medical Centre, 
      Singapore, Singapore.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220401
PL  - United States
TA  - Sci Immunol
JT  - Science immunology
JID - 101688624
SB  - IM
MH  - Adaptive Immunity
MH  - *Dendritic Cells
MH  - Humans
MH  - *Neoplasms
EDAT- 2022/04/02 06:00
MHDA- 2022/04/06 06:00
CRDT- 2022/04/01 17:13
PHST- 2022/04/01 17:13 [entrez]
PHST- 2022/04/02 06:00 [pubmed]
PHST- 2022/04/06 06:00 [medline]
AID - 10.1126/sciimmunol.abm9409 [doi]
PST - ppublish
SO  - Sci Immunol. 2022 Apr;7(70):eabm9409. doi: 10.1126/sciimmunol.abm9409. Epub 2022 
      Apr 1.