PMID- 35363864
OWN - NLM
STAT- MEDLINE
DCOM- 20220930
LR  - 20221026
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 226
IP  - 7
DP  - 2022 Sep 28
TI  - Role of Human Leukocyte Antigen Allele Sharing in Human Papillomavirus Infection 
      Transmission Among Heterosexual Couples: Findings From the HITCH Cohort Study.
PG  - 1175-1183
LID - 10.1093/infdis/jiac115 [doi]
AB  - BACKGROUND: Human leukocyte antigen (HLA) polymorphism influences innate and 
      adaptive immune responses. Among heterosexual couples in the HPV Infection and 
      Transmission Among Couples Through Heterosexual Activity (HITCH) cohort study, we 
      examined whether allele sharing in a couple predicted the partners' infections 
      with the same human papillomavirus (HPV) type. METHODS: We tested genital samples 
      from 271 couples for 36 HPV genotypes by polymerase chain reaction. We used 
      direct DNA sequencing to type HLA-B07, -DRB1, -DQB1 and -G. Generalized 
      estimating equations were used to examine the associations between the extent of 
      allele sharing and HPV type concordance in which at least 1 of the partners was 
      HPV positive. RESULTS: We identified 106 different HLA alleles. The most common 
      HLA alleles among couples were G*01:01:01 (95.6%), G*01:01:02 (60.1%), DQB1*03:01 
      (57.2%), and DRB1*07:01 (46.9%). Allele sharing was as follows: 19.6% shared 
      none, 43.2% shared 1 only, 25.1% shared 2, and 12.5% shared 3-5. Irrespective of 
      HLA class, grouped or in combination, the extent of allele sharing was not a 
      significant predictor of type-specific HPV concordance in a couple (odds 
      ratio, 1.1 [95% confidence interval, .5-2.1], for 3-5 vs none). CONCLUSIONS: We 
      found no evidence that the extent of HLA allele concordance influences the 
      likelihood of HPV transmission in newly formed heterosexual couples.
CI  - (c) The Author(s) 2022. Published by Oxford University Press for the Infectious 
      Diseases Society of America.
FAU - Louvanto, Karolina
AU  - Louvanto K
AUID- ORCID: 0000-0002-1172-363X
AD  - Division of Cancer Epidemiology, McGill University, Montreal, Quebec, Canada.
AD  - Department of Obstetrics and Gynaecology, Faculty of Medicine and Health 
      Technology, Tampere University, Tampere, Finland.
AD  - Department of Obstetrics and Gynaecology, Tampere University Hospital, Tampere, 
      Finland.
FAU - Baral, Prativa
AU  - Baral P
AD  - Division of Cancer Epidemiology, McGill University, Montreal, Quebec, Canada.
FAU - Burchell, Ann
AU  - Burchell A
AD  - Ontario HIV Treatment Network, Toronto, Ontario, Canada.
FAU - Ramanakumar, Agnihotram
AU  - Ramanakumar A
AD  - Division of Cancer Epidemiology, McGill University, Montreal, Quebec, Canada.
FAU - El-Zein, Mariam
AU  - El-Zein M
AUID- ORCID: 0000-0002-5190-0370
AD  - Division of Cancer Epidemiology, McGill University, Montreal, Quebec, Canada.
FAU - Tellier, Pierre Paul
AU  - Tellier PP
AD  - Department of Family Medicine, McGill University, Montreal, Quebec, Canada.
FAU - Coutlee, Francois
AU  - Coutlee F
AD  - Division of Cancer Epidemiology, McGill University, Montreal, Quebec, Canada.
AD  - Centre de recherche du Centre hospitalier de l'Universite de Montreal et 
      Departement de microbiologie, infectiologie et immunologie, Universite de 
      Montreal, Montreal, Quebec, Canada.
FAU - Roger, Michel
AU  - Roger M
AD  - Centre de recherche du Centre hospitalier de l'Universite de Montreal et 
      Departement de microbiologie, infectiologie et immunologie, Universite de 
      Montreal, Montreal, Quebec, Canada.
FAU - Franco, Eduardo L
AU  - Franco EL
AD  - Division of Cancer Epidemiology, McGill University, Montreal, Quebec, Canada.
LA  - eng
GR  - R01 AI073889/AI/NIAID NIH HHS/United States
GR  - MOP-68893 and CRN-83320/CIHR/Canada
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - Cohort Studies
MH  - HLA Antigens/genetics
MH  - Heterosexuality
MH  - Humans
MH  - Papillomaviridae/genetics
MH  - *Papillomavirus Infections
PMC - PMC9518836
OTO - NOTNLM
OT  - HLA
OT  - HPV
OT  - cervical
OT  - couple
OT  - heterosexual
OT  - transmission
COIS- Potential conflicts of interest. E. L. F. has served as an occasional advisor to 
      companies involved with HPV diagnostics (Roche, BD, Abbott) and HPV vaccines 
      (Merck, GSK), and his institution has received unconditional grants from Merck in 
      aid of investigator-initiated studies. F. C. has received grants through his 
      institution from Merck and Roche, as well as honoraria from Merck and Roche for 
      lectures on HPV. All other authors report no potential conflicts of interest. All 
      authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of 
      Interest. Conflicts that the editors consider relevant to the content of the 
      manuscript have been disclosed. Presented in part: 30th International 
      Papillomavirus Society Conference, Lisbon, Portugal, 17-21 September 2015.
EDAT- 2022/04/02 06:00
MHDA- 2022/10/01 06:00
PMCR- 2022/04/01
CRDT- 2022/04/01 17:15
PHST- 2021/12/24 00:00 [received]
PHST- 2022/03/29 00:00 [accepted]
PHST- 2022/04/02 06:00 [pubmed]
PHST- 2022/10/01 06:00 [medline]
PHST- 2022/04/01 17:15 [entrez]
PHST- 2022/04/01 00:00 [pmc-release]
AID - 6562380 [pii]
AID - jiac115 [pii]
AID - 10.1093/infdis/jiac115 [doi]
PST - ppublish
SO  - J Infect Dis. 2022 Sep 28;226(7):1175-1183. doi: 10.1093/infdis/jiac115.