PMID- 35365118
OWN - NLM
STAT- MEDLINE
DCOM- 20220405
LR  - 20220405
IS  - 1471-2415 (Electronic)
IS  - 1471-2415 (Linking)
VI  - 22
IP  - 1
DP  - 2022 Apr 1
TI  - Thickness measurements taken with the spectralis OCT increase with decreasing 
      signal strength.
PG  - 148
LID - 10.1186/s12886-022-02356-4 [doi]
LID - 148
AB  - BACKGROUND: Optical coherence tomography (OCT) is used worldwide by clinicians to 
      evaluate macular and retinal nerve fiber layer (RNFL) characteristics. It is 
      frequently utilized to assess disease severity, progression and efficacy of 
      treatment, and therefore must be reliable and reproducible. OBJECTIVE: To examine 
      the influence of signal strength on macular thickness parameters, macular volume 
      measurement and RNFL thickness measured by spectral-domain optical coherence 
      tomography (SD-OCT). METHODS: Macular thickness parameters, macular volume 
      measurement and RNFL thickness were measured by the Spectralis(R) OCT (Heidelberg 
      Engineering, Heidelberg, Germany). In each eye, the focusing knob was adjusted to 
      obtain 4 images with different signal strengths - Low (below 15), Moderate 
      (15-20), Good (20-25) and Excellent (above 25). The relationship between signal 
      strength and measured data was assessed using the mixed model procedure. RESULTS: 
      A total of 71 eyes of 41 healthy subjects were included. Central macular 
      thickness, macular volume and mean RNFL thickness increased with decreasing 
      signal strength. Specifically, eyes with excellent signal strength showed 
      significantly thinner central macular thickness (p = 0.023), macular volume 
      (p = 0.047), and mean RNFL thickness (p = 0.0139). CONCLUSIONS: Higher signal 
      strength is associated with lower macular thickness, macular volume and RNFL 
      thickness measurements. The mean differences between excellent and low-quality 
      measurements were small implicating that SD-OCT is a reliable imaging tool even 
      at low quality scans. It is imperative that the physician compares the signal 
      strength of all scans, as minute differences may alter results.
CI  - (c) 2022. The Author(s).
FAU - Gershoni, Assaf
AU  - Gershoni A
AD  - Department of Ophthalmology, Rabin Medical Center, Petah Tikva, Israel.
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Barayev, Edward
AU  - Barayev E
AD  - Department of Ophthalmology, Rabin Medical Center, Petah Tikva, Israel.
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Vainer, Igor
AU  - Vainer I
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
AD  - Department of Otolaryngology, Rabin Medical Center, Petah Tikva, Israel.
FAU - Allon, Raviv
AU  - Allon R
AD  - Department of Otolaryngology, Kaplan Medical Center, Rehovot, Israel.
FAU - Yavnieli, Roy
AU  - Yavnieli R
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
AD  - Department of Ophthalmology, Meir Medical Center, Kfar Saba, Israel.
FAU - Shapira, Yinon
AU  - Shapira Y
AD  - Department of Ophthalmology, Rambam Health Care Campus, Haifa, Israel.
FAU - Mimouni, Michael
AU  - Mimouni M
AD  - Department of Ophthalmology, Rambam Health Care Campus, Haifa, Israel.
FAU - Geffen, Noa
AU  - Geffen N
AD  - Department of Ophthalmology, Rabin Medical Center, Petah Tikva, Israel.
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Nemet, Arie Yehuda
AU  - Nemet AY
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
AD  - Department of Ophthalmology, Meir Medical Center, Kfar Saba, Israel.
FAU - Segal, Ori
AU  - Segal O
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 
      orisegal@gmail.com.
AD  - Department of Ophthalmology, Meir Medical Center, Kfar Saba, Israel. 
      orisegal@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20220401
PL  - England
TA  - BMC Ophthalmol
JT  - BMC ophthalmology
JID - 100967802
SB  - IM
MH  - Humans
MH  - Nerve Fibers
MH  - *Optic Disk
MH  - Retina/diagnostic imaging
MH  - Retinal Ganglion Cells
MH  - *Tomography, Optical Coherence/methods
PMC - PMC8976355
OTO - NOTNLM
OT  - Macular thickness
OT  - Optical Coherence tomography
OT  - Retinal nerve fiber layer
OT  - Signal strength
OT  - Spectralis
COIS- All authors declare no conflict of interest.
EDAT- 2022/04/03 06:00
MHDA- 2022/04/06 06:00
PMCR- 2022/04/01
CRDT- 2022/04/02 05:21
PHST- 2021/05/29 00:00 [received]
PHST- 2021/10/07 00:00 [accepted]
PHST- 2022/04/02 05:21 [entrez]
PHST- 2022/04/03 06:00 [pubmed]
PHST- 2022/04/06 06:00 [medline]
PHST- 2022/04/01 00:00 [pmc-release]
AID - 10.1186/s12886-022-02356-4 [pii]
AID - 2356 [pii]
AID - 10.1186/s12886-022-02356-4 [doi]
PST - epublish
SO  - BMC Ophthalmol. 2022 Apr 1;22(1):148. doi: 10.1186/s12886-022-02356-4.