PMID- 35365934
OWN - NLM
STAT- MEDLINE
DCOM- 20220912
LR  - 20220920
IS  - 1349-7006 (Electronic)
IS  - 1347-9032 (Print)
IS  - 1347-9032 (Linking)
VI  - 113
IP  - 9
DP  - 2022 Sep
TI  - Glycoprotein NMB promotes tumor formation and malignant progression of laryngeal 
      squamous cell carcinoma.
PG  - 3244-3254
LID - 10.1111/cas.15359 [doi]
AB  - Laryngeal squamous cell carcinoma (LSCC), although one of the most common head 
      and neck cancers, has a static or slightly decreased survival rate because of 
      difficulties in early diagnosis, lack of effective molecular targeting therapy, 
      and severe dysfunction after radical surgical treatments. Therefore, a novel 
      therapeutic target is crucial to increase treatment efficacy and survival rates 
      in these patients. Glycoprotein NMB (GPNMB), whose role in LSCC remains elusive, 
      is a type 1 transmembrane protein involved in malignant progression of various 
      cancers, and its high expression is thought to be a poor prognostic factor. In 
      this study, we showed that GPNMB expression levels in LSCC samples are 
      significantly higher than those in normal tissues, and GPNMB expression is 
      observed mostly in growth-arrested cancer cells. Furthermore, knockdown of GPNMB 
      reduces monolayer cellular proliferation, cellular migration, and tumorigenic 
      growth, while GPNMB protein displays an inverse relationship with Ki-67 levels. 
      Therefore, we conclude that GPNMB may be an attractive target for future LSCC 
      therapy.
CI  - (c) 2022 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd 
      on behalf of Japanese Cancer Association.
FAU - Manevich, Lev
AU  - Manevich L
AD  - Experimental Pathology, Faculty of Medicine, University of Tsukuba, Ibaraki, 
      Japan.
AD  - Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, 
      Japan.
FAU - Okita, Yukari
AU  - Okita Y
AUID- ORCID: 0000-0002-7279-4634
AD  - Experimental Pathology, Faculty of Medicine, University of Tsukuba, Ibaraki, 
      Japan.
AD  - Division of Cell Dynamics, Transborder Medical Research Center, University of 
      Tsukuba, Ibaraki, Japan.
FAU - Okano, Yasuhito
AU  - Okano Y
AD  - Experimental Pathology, Faculty of Medicine, University of Tsukuba, Ibaraki, 
      Japan.
AD  - Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, 
      Japan.
AD  - Otolaryngology, Head and Neck Surgery, Faculty of Medicine, University of 
      Tsukuba, Ibaraki, Japan.
FAU - Sugasawa, Takehito
AU  - Sugasawa T
AD  - Laboratory of Sports Medicine, Division of Clinical Medicine, Faculty of 
      Medicine, University of Tsukuba, Ibaraki, Japan.
FAU - Kawanishi, Kunio
AU  - Kawanishi K
AD  - Experimental Pathology, Faculty of Medicine, University of Tsukuba, Ibaraki, 
      Japan.
FAU - Poullikkas, Thanasis
AU  - Poullikkas T
AD  - Experimental Pathology, Faculty of Medicine, University of Tsukuba, Ibaraki, 
      Japan.
AD  - Human Biology, School of integrative and Global Majors, University of Tsukuba, 
      Ibaraki, Japan.
FAU - Dang Cao, Linda T L
AU  - Dang Cao LTL
AD  - Experimental Pathology, Faculty of Medicine, University of Tsukuba, Ibaraki, 
      Japan.
AD  - Ph.D. Program in Humanics, School of Integrative and Global Majors (SIGMA), 
      University of Tsukuba, Ibaraki, Japan.
AD  - Life and Science Center of Survival Dynamics, Tsukuba Advanced Research Alliance 
      (TARA), University of Tsukuba, Ibaraki, Japan.
FAU - Zheng, Ling
AU  - Zheng L
AD  - Experimental Pathology, Faculty of Medicine, University of Tsukuba, Ibaraki, 
      Japan.
FAU - Nakayama, Masahiro
AU  - Nakayama M
AUID- ORCID: 0000-0001-9285-7877
AD  - Otolaryngology, Head and Neck Surgery, Faculty of Medicine, University of 
      Tsukuba, Ibaraki, Japan.
FAU - Matsumoto, Shin
AU  - Matsumoto S
AD  - Otolaryngology, Head and Neck Surgery, Faculty of Medicine, University of 
      Tsukuba, Ibaraki, Japan.
FAU - Tabuchi, Keiji
AU  - Tabuchi K
AD  - Otolaryngology, Head and Neck Surgery, Faculty of Medicine, University of 
      Tsukuba, Ibaraki, Japan.
FAU - Kato, Mitsuyasu
AU  - Kato M
AUID- ORCID: 0000-0001-9905-2473
AD  - Experimental Pathology, Faculty of Medicine, University of Tsukuba, Ibaraki, 
      Japan.
AD  - Division of Cell Dynamics, Transborder Medical Research Center, University of 
      Tsukuba, Ibaraki, Japan.
LA  - eng
GR  - JP18H02676/Japan Society for the Promotion of Science/
GR  - JP19K07658/Japan Society for the Promotion of Science/
GR  - JP19K17730/Japan Society for the Promotion of Science/
GR  - JP20K20597/Japan Society for the Promotion of Science/
PT  - Journal Article
DEP - 20220518
PL  - England
TA  - Cancer Sci
JT  - Cancer science
JID - 101168776
RN  - 0 (GPNMB protein, human)
RN  - 0 (Glycoproteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (MicroRNAs)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Cell Line, Tumor
MH  - Cell Proliferation/genetics
MH  - Gene Expression Regulation, Neoplastic
MH  - Glycoproteins/metabolism
MH  - *Head and Neck Neoplasms
MH  - Humans
MH  - *Laryngeal Neoplasms/genetics/pathology
MH  - Membrane Glycoproteins/genetics/metabolism
MH  - *MicroRNAs
MH  - Promoter Regions, Genetic
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Transcription Factors/metabolism
PMC - PMC9459245
OTO - NOTNLM
OT  - cell migration
OT  - dormancy
OT  - glycoprotein NMB
OT  - laryngeal squamous cell carcinoma
OT  - tumorigenesis
EDAT- 2022/04/03 06:00
MHDA- 2022/09/14 06:00
PMCR- 2022/09/01
CRDT- 2022/04/02 05:28
PHST- 2022/03/16 00:00 [revised]
PHST- 2021/11/17 00:00 [received]
PHST- 2022/03/28 00:00 [accepted]
PHST- 2022/04/03 06:00 [pubmed]
PHST- 2022/09/14 06:00 [medline]
PHST- 2022/04/02 05:28 [entrez]
PHST- 2022/09/01 00:00 [pmc-release]
AID - CAS15359 [pii]
AID - 10.1111/cas.15359 [doi]
PST - ppublish
SO  - Cancer Sci. 2022 Sep;113(9):3244-3254. doi: 10.1111/cas.15359. Epub 2022 May 18.