PMID- 35366853
OWN - NLM
STAT- MEDLINE
DCOM- 20220405
LR  - 20220408
IS  - 1472-6823 (Electronic)
IS  - 1472-6823 (Linking)
VI  - 22
IP  - 1
DP  - 2022 Apr 2
TI  - Ultrasonography evaluation on the protective effect of combination therapy of 
      beraprost sodium and aspirin on arteries occlusion and stiffness in patients with 
      type 2 diabetes mellitus - a prospective, randomized study.
PG  - 87
LID - 10.1186/s12902-022-01007-5 [doi]
LID - 87
AB  - BACKGROUND: Patients with type 2 diabetes mellitus (T2DM) are susceptible to 
      developing symptomatic peripheral arterial disease (PAD). As a proven vasodilator 
      and antiplatelet agent, the efficiency of Beraprost sodium (BPS) on the 
      prevention of arteries occlusion and stiffness in T2DM patients with PAD has not 
      yet been fully investigated. METHODS: From July 2010 to April 2012, 64 Patients 
      enrolled were randomly assigned to the combined therapy group (n=32), which 
      received combination therapy with BPS (60 mug/day) and aspirin (100 mg/day), or to 
      the control group (n=32), which only received aspirin (100 mg/day). After 
      randomization, the patients were followed up at years 0, 1, 2, 3, 4, and 5 with 
      the evaluation of carotid intima-media thickness (CIMT), pulse wave velocity 
      (PWV), inner artery diameter, stenosis rate, and medial arterial calcification 
      (MAC) of lower limb arteries via high-resolution ultrasound measurement. Adverse 
      events were also recorded in each visit. RESULTS: There was no significant change 
      of the CIMT during the follow-up in both groups when compared to the baseline. 
      Similar results were also observed in the PWV measurement. Significantly 
      increases in the inner artery diameter of the dorsal pedal artery and posterior 
      tibial artery were observed in patients with BPS and aspirin administration 
      during the follow-up. Patients in the combined therapy group experienced marked 
      improvement of MAC in the dorsal pedal artery and posterior tibial artery at the 
      end of the follow-up. No significant difference in the adverse events was found 
      between the combined therapy group and the aspirin group. CONCLUSION: The 
      combined therapy of BPS and aspirin showed a protective effect on arteries 
      occlusion and stiffness in T2DM patients with PAD, along with a significant 
      improvement of inner artery diameter and MAC in lower limbs. TRIAL REGISTRATION: 
      http://www.chictr.org.cn , ChiCTR-TRC-10000919. Prospectively registered on 
      2010/06/29.
CI  - (c) 2022. The Author(s).
FAU - Lin, Xian
AU  - Lin X
AD  - Department of Ultrasound, Guangdong Province Traditional Chinese Medical 
      Hospital, 111, Dade Road, Yuexiu District, Guangzhou, Guangdong, China.
AD  - Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-Sen 
      University, 107, Yanjiangxi Road, Yuexiu District, Guangzhou, Guangdong, PR 
      China.
FAU - Chen, Yuying
AU  - Chen Y
AD  - Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-Sen 
      University, 107, Yanjiangxi Road, Yuexiu District, Guangzhou, Guangdong, PR 
      China.
FAU - Lu, Wan
AU  - Lu W
AD  - Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-Sen 
      University, 107, Yanjiangxi Road, Yuexiu District, Guangzhou, Guangdong, PR 
      China.
FAU - Li, Jin
AU  - Li J
AD  - Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-Sen 
      University, 107, Yanjiangxi Road, Yuexiu District, Guangzhou, Guangdong, PR 
      China.
FAU - Fu, Li
AU  - Fu L
AD  - Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-Sen 
      University, 107, Yanjiangxi Road, Yuexiu District, Guangzhou, Guangdong, PR 
      China.
FAU - Yin, Jingyu
AU  - Yin J
AD  - Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-Sen 
      University, 107, Yanjiangxi Road, Yuexiu District, Guangzhou, Guangdong, PR 
      China.
FAU - Ren, Meng
AU  - Ren M
AD  - Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-Sen 
      University, 107, Yanjiangxi Road, Yuexiu District, Guangzhou, Guangdong, PR 
      China.
FAU - Yan, Li
AU  - Yan L
AD  - Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-Sen 
      University, 107, Yanjiangxi Road, Yuexiu District, Guangzhou, Guangdong, PR 
      China.
FAU - Yang, Chuan
AU  - Yang C
AD  - Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-Sen 
      University, 107, Yanjiangxi Road, Yuexiu District, Guangzhou, Guangdong, PR 
      China. yangchuangsysu@163.com.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20220402
PL  - England
TA  - BMC Endocr Disord
JT  - BMC endocrine disorders
JID - 101088676
RN  - 35E3NJJ4O6 (beraprost)
RN  - DCR9Z582X0 (Epoprostenol)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Arteries
MH  - *Aspirin/therapeutic use
MH  - Carotid Intima-Media Thickness
MH  - *Diabetes Mellitus, Type 2/complications/drug therapy
MH  - Epoprostenol/analogs & derivatives
MH  - Humans
MH  - Prospective Studies
MH  - Pulse Wave Analysis
MH  - Ultrasonography
PMC - PMC8977025
OTO - NOTNLM
OT  - Aspirin
OT  - Atherosclerosis
OT  - Beraprost Sodium
OT  - Medial Arterial Calcification
OT  - Type 2 Diabetes Mellitus
COIS- The authors have no conflicts of interest.
EDAT- 2022/04/04 06:00
MHDA- 2022/04/06 06:00
PMCR- 2022/04/02
CRDT- 2022/04/03 20:21
PHST- 2021/06/12 00:00 [received]
PHST- 2022/03/30 00:00 [accepted]
PHST- 2022/04/03 20:21 [entrez]
PHST- 2022/04/04 06:00 [pubmed]
PHST- 2022/04/06 06:00 [medline]
PHST- 2022/04/02 00:00 [pmc-release]
AID - 10.1186/s12902-022-01007-5 [pii]
AID - 1007 [pii]
AID - 10.1186/s12902-022-01007-5 [doi]
PST - epublish
SO  - BMC Endocr Disord. 2022 Apr 2;22(1):87. doi: 10.1186/s12902-022-01007-5.