PMID- 35367027
OWN - NLM
STAT- MEDLINE
DCOM- 20220405
LR  - 20220519
IS  - 1548-5609 (Electronic)
IS  - 1548-5595 (Linking)
VI  - 28
IP  - 6
DP  - 2021 Nov
TI  - Approach to Highly Sensitized Kidney Transplant Candidates and a Positive 
      Crossmatch.
PG  - 587-595
LID - S1548-5595(21)00093-8 [pii]
LID - 10.1053/j.ackd.2021.09.004 [doi]
AB  - Human leukocyte antigen (HLA)-incompatible kidney transplantation offers survival 
      benefit compared with ongoing dialysis. There have been considerable advances in 
      the last decade to allow for increased access to transplant for the 
      HLA-sensitized kidney transplant candidates. These include increased priority in 
      the kidney allocation system, kidney paired donation, and novel desensitization 
      strategies. A better understanding of the role of B cells, plasma cells, and 
      complement and inflammatory cytokines in the pathophysiology of HLA 
      antibody-mediated allograft injury has led to the use of novel therapeutics for 
      desensitization and treatment of antibody-mediated rejection. Here we discuss 
      current approaches to kidney transplantation in HLA-sensitized kidney transplant 
      candidates.
CI  - Copyright (c) 2021 National Kidney Foundation, Inc. Published by Elsevier Inc. All 
      rights reserved.
FAU - Sethi, Supreet
AU  - Sethi S
AD  - Comprehensive Transplant Center, Cedars Sinai Medical Center, Los Angeles, CA. 
      Electronic address: supreet.sethi@cshs.org.
FAU - Ammerman, Noriko
AU  - Ammerman N
AD  - Comprehensive Transplant Center, Cedars Sinai Medical Center, Los Angeles, CA.
FAU - Vo, Ashley
AU  - Vo A
AD  - Comprehensive Transplant Center, Cedars Sinai Medical Center, Los Angeles, CA.
FAU - Jordan, Stanley C
AU  - Jordan SC
AD  - Comprehensive Transplant Center, Cedars Sinai Medical Center, Los Angeles, CA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Chronic Kidney Dis
JT  - Advances in chronic kidney disease
JID - 101209214
RN  - 0 (HLA Antigens)
SB  - IM
MH  - HLA Antigens
MH  - Humans
MH  - *Kidney Transplantation
MH  - Living Donors
MH  - Transplantation, Homologous
OTO - NOTNLM
OT  - Desensitization
OT  - Donor-specific antibody
OT  - HLA-sensitized
OT  - Incompatible
OT  - Kidney paired donation
EDAT- 2022/04/04 06:00
MHDA- 2022/04/06 06:00
CRDT- 2022/04/03 20:22
PHST- 2021/05/29 00:00 [received]
PHST- 2021/09/08 00:00 [accepted]
PHST- 2022/04/03 20:22 [entrez]
PHST- 2022/04/04 06:00 [pubmed]
PHST- 2022/04/06 06:00 [medline]
AID - S1548-5595(21)00093-8 [pii]
AID - 10.1053/j.ackd.2021.09.004 [doi]
PST - ppublish
SO  - Adv Chronic Kidney Dis. 2021 Nov;28(6):587-595. doi: 10.1053/j.ackd.2021.09.004.