PMID- 35367260
OWN - NLM
STAT- MEDLINE
DCOM- 20220603
LR  - 20220603
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 831
DP  - 2022 Jul 20
TI  - Perfluorinated alkyl substances in Canadian human milk as part of the 
      Maternal-Infant Research on Environmental Chemicals (MIREC) study.
PG  - 154888
LID - S0048-9697(22)01981-7 [pii]
LID - 10.1016/j.scitotenv.2022.154888 [doi]
AB  - Perfluorinated alkyl substances (PFAS) were determined in human milk samples (n = 
      664) from participants in the Maternal-Infant Research on Environmental Chemicals 
      (MIREC) study. SigmaPFAS concentrations (sum of seven PFAS) ranged from 3.1 ng L(-1) 
      to 603 ng L(-1), with a median concentration of 106 ng L(-1) in the Canadian 
      mothers' milk analyzed. These data comprise the first pan-Canadian dataset of 
      PFAS in human milk. Perfluorooctanoic acid (PFOA) and linear 
      perfluorooctanesulfonate (L-PFOS) were the dominant contributors to SigmaPFAS in 
      human milk samples. An inverse relationship between SigmaPFAS concentrations and age 
      was observed (Spearman correlation - 0.184). Primiparous women had elevated PFAS 
      concentrations in milk relative to women who had children previously (p < 0.001). 
      In contrast, the region of maternal birth did not influence SigmaPFAS concentrations 
      (p = 0.156). Although China and Norway have observed consistently detectable 
      levels of perfluoroundecanoic acid (PFUdA) in human milk, PFAS with long carbon 
      chains (n >/= 11) were not present above method detection limits in Canadian human 
      milk samples analyzed as part of the MIREC study. In conclusion, despite the 
      presence of low levels of environmental contaminants in human milk, Health Canada 
      supports breastfeeding due to the benefits to both infants and mothers.
CI  - Crown Copyright (c) 2022. Published by Elsevier B.V. All rights reserved.
FAU - Rawn, Dorothea F K
AU  - Rawn DFK
AD  - Food Research Division, Bureau of Chemical Safety, Health Products and Food 
      Branch, Health Canada, Sir Frederick Banting Research Centre, 251 Sir Frederick 
      Banting Driveway, Address Locator: 2203C, Tunney's Pasture, Ottawa, ON K1A 0K9, 
      Canada. Electronic address: thea.rawn@hc-sc.gc.ca.
FAU - Dufresne, Guy
AU  - Dufresne G
AD  - Health Canada, Health Products Laboratory Program, Health Products Laboratory and 
      Microbiology Laboratory Longueuil, 1001 Saint-Laurent Ouest, Longueuil, QC J4K 
      1C7, Canada.
FAU - Clement, Genevieve
AU  - Clement G
AD  - Health Canada, Health Products Laboratory Program, Health Products Laboratory and 
      Microbiology Laboratory Longueuil, 1001 Saint-Laurent Ouest, Longueuil, QC J4K 
      1C7, Canada.
FAU - Fraser, William D
AU  - Fraser WD
AD  - CHU Sainte-Justine, Centre de recherche, Universite de Montreal, Montreal, QC, 
      Canada. Current Address: Centre hospitalier Universitaire de Sherbrooke, 
      Sherbrooke, QC, Canada.
FAU - Arbuckle, Tye E
AU  - Arbuckle TE
AD  - Environmental Health Science and Research Bureau, Environmental and Radiation 
      Health Sciences Directorate, Healthy Environments and Consumer Safety Branch, 
      Health Canada, 50 Colombine Driveway, Address Locator: 0801A, Tunney's Pasture, 
      Ottawa, ON K1A 0K9, Canada.
LA  - eng
PT  - Journal Article
DEP - 20220330
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
SB  - IM
MH  - *Alkanesulfonic Acids/analysis
MH  - Canada
MH  - Child
MH  - China
MH  - *Environmental Pollutants/analysis
MH  - Female
MH  - *Fluorocarbons/analysis
MH  - Humans
MH  - Infant
MH  - Milk, Human/chemistry
MH  - Mothers
OTO - NOTNLM
OT  - Human milk
OT  - LC-MS/MS
OT  - Liquid chromatography-mass spectrometry
OT  - PFAS
OT  - Perfluorinated substances
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/04/04 06:00
MHDA- 2022/06/07 06:00
CRDT- 2022/04/03 20:24
PHST- 2021/12/10 00:00 [received]
PHST- 2022/03/23 00:00 [revised]
PHST- 2022/03/24 00:00 [accepted]
PHST- 2022/04/04 06:00 [pubmed]
PHST- 2022/06/07 06:00 [medline]
PHST- 2022/04/03 20:24 [entrez]
AID - S0048-9697(22)01981-7 [pii]
AID - 10.1016/j.scitotenv.2022.154888 [doi]
PST - ppublish
SO  - Sci Total Environ. 2022 Jul 20;831:154888. doi: 10.1016/j.scitotenv.2022.154888. 
      Epub 2022 Mar 30.