PMID- 35369480
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220405
IS  - 1664-302X (Print)
IS  - 1664-302X (Electronic)
IS  - 1664-302X (Linking)
VI  - 13
DP  - 2022
TI  - Targeting Gut Microbiota With Natural Polysaccharides: Effective Interventions 
      Against High-Fat Diet-Induced Metabolic Diseases.
PG  - 859206
LID - 10.3389/fmicb.2022.859206 [doi]
LID - 859206
AB  - Unhealthy diet, in particular high-fat diet (HFD) intake, can cause the 
      development of several metabolic disorders, including obesity, hyperlipidemia, 
      type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and 
      metabolic syndrome (MetS). These popular metabolic diseases reduce the quality of 
      life, and induce premature death worldwide. Evidence is accumulating that the gut 
      microbiota is inextricably associated with HFD-induced metabolic disorders, and 
      dietary intervention of gut microbiota is an effective therapeutic strategy for 
      these metabolic dysfunctions. Polysaccharides are polymeric carbohydrate 
      macromolecules and sources of fermentable dietary fiber that exhibit biological 
      activities in the prevention and treatment of HFD-induced metabolic diseases. Of 
      note, natural polysaccharides are among the most potent modulators of the gut 
      microbiota composition. However, the prebiotics-like effects of polysaccharides 
      in treating HFD-induced metabolic diseases remain elusive. In this review, we 
      introduce the critical role of gut microbiota human health and HFD-induced 
      metabolic disorders. Importantly, we review current knowledge about the role of 
      natural polysaccharides in improving HFD-induced metabolic diseases by regulating 
      gut microbiota.
CI  - Copyright (c) 2022 Sun, Zheng, Chen, Lu and Liu.
FAU - Sun, Chao-Yue
AU  - Sun CY
AD  - College of Biological and Pharmaceutical Engineering, West Anhui University, 
      Lu'an, China.
FAU - Zheng, Zuo-Liang
AU  - Zheng ZL
AD  - School of Life Science, Jiaying University, Meizhou, China.
FAU - Chen, Cun-Wu
AU  - Chen CW
AD  - College of Biological and Pharmaceutical Engineering, West Anhui University, 
      Lu'an, China.
FAU - Lu, Bao-Wei
AU  - Lu BW
AD  - College of Biological and Pharmaceutical Engineering, West Anhui University, 
      Lu'an, China.
FAU - Liu, Dong
AU  - Liu D
AD  - College of Biological and Pharmaceutical Engineering, West Anhui University, 
      Lu'an, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220315
PL  - Switzerland
TA  - Front Microbiol
JT  - Frontiers in microbiology
JID - 101548977
PMC - PMC8965082
OTO - NOTNLM
OT  - gut microbiota
OT  - high-fat diet
OT  - metabolic diseases
OT  - obesity
OT  - polysaccharides
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/04/05 06:00
MHDA- 2022/04/05 06:01
PMCR- 2022/03/15
CRDT- 2022/04/04 05:20
PHST- 2022/01/21 00:00 [received]
PHST- 2022/02/22 00:00 [accepted]
PHST- 2022/04/04 05:20 [entrez]
PHST- 2022/04/05 06:00 [pubmed]
PHST- 2022/04/05 06:01 [medline]
PHST- 2022/03/15 00:00 [pmc-release]
AID - 10.3389/fmicb.2022.859206 [doi]
PST - epublish
SO  - Front Microbiol. 2022 Mar 15;13:859206. doi: 10.3389/fmicb.2022.859206. 
      eCollection 2022.