PMID- 35370908 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220716 IS - 1664-2295 (Print) IS - 1664-2295 (Electronic) IS - 1664-2295 (Linking) VI - 13 DP - 2022 TI - Interictal EEG and ECG for SUDEP Risk Assessment: A Retrospective Multicenter Cohort Study. PG - 858333 LID - 10.3389/fneur.2022.858333 [doi] LID - 858333 AB - OBJECTIVE: Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related mortality. Although lots of effort has been made in identifying clinical risk factors for SUDEP in the literature, there are few validated methods to predict individual SUDEP risk. Prolonged postictal EEG suppression (PGES) is a potential SUDEP biomarker, but its occurrence is infrequent and requires epilepsy monitoring unit admission. We use machine learning methods to examine SUDEP risk using interictal EEG and ECG recordings from SUDEP cases and matched living epilepsy controls. METHODS: This multicenter, retrospective, cohort study examined interictal EEG and ECG recordings from 30 SUDEP cases and 58 age-matched living epilepsy patient controls. We trained machine learning models with interictal EEG and ECG features to predict the retrospective SUDEP risk for each patient. We assessed cross-validated classification accuracy and the area under the receiver operating characteristic (AUC) curve. RESULTS: The logistic regression (LR) classifier produced the overall best performance, outperforming the support vector machine (SVM), random forest (RF), and convolutional neural network (CNN). Among the 30 patients with SUDEP [14 females; mean age (SD), 31 (8.47) years] and 58 living epilepsy controls [26 females (43%); mean age (SD) 31 (8.5) years], the LR model achieved the median AUC of 0.77 [interquartile range (IQR), 0.73-0.80] in five-fold cross-validation using interictal alpha and low gamma power ratio of the EEG and heart rate variability (HRV) features extracted from the ECG. The LR model achieved the mean AUC of 0.79 in leave-one-center-out prediction. CONCLUSIONS: Our results support that machine learning-driven models may quantify SUDEP risk for epilepsy patients, future refinements in our model may help predict individualized SUDEP risk and help clinicians correlate predictive scores with the clinical data. Low-cost and noninvasive interictal biomarkers of SUDEP risk may help clinicians to identify high-risk patients and initiate preventive strategies. CI - Copyright (c) 2022 Chen, Hsieh, Sun, Bergey, Berkovic, Perucca, D'Souza, Elder, Farooque, Johnson, Barnard, Nightscales, Kwan, Moseley, O'Brien, Sivathamboo, Laze, Friedman, Devinsky and The MS-BioS Study Group. FAU - Chen, Zhe Sage AU - Chen ZS AD - Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, United States. AD - Neuroscience Institute, New York University Grossman School of Medicine, New York, NY, United States. FAU - Hsieh, Aaron AU - Hsieh A AD - Tandon School of Engineering, New York University, New York, NY, United States. FAU - Sun, Guanghao AU - Sun G AD - Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, United States. FAU - Bergey, Gregory K AU - Bergey GK AD - Johns Hopkins University School of Medicine, Baltimore, MD, United States. FAU - Berkovic, Samuel F AU - Berkovic SF AD - Department of Medicine (Austin Health), The University of Melbourne, Heidelberg, VIC, Australia. AD - Comprehensive Epilepsy Program, Department of Neurology, Austin Health, Heidelberg, VIC, Australia. FAU - Perucca, Piero AU - Perucca P AD - Department of Medicine (Austin Health), The University of Melbourne, Heidelberg, VIC, Australia. AD - Comprehensive Epilepsy Program, Department of Neurology, Austin Health, Heidelberg, VIC, Australia. AD - Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia. AD - Department of Neurology, Alfred Health, Melbourne, VIC, Australia. AD - Department of Neurology, The Royal Melbourne Hospital, Melbourne, VIC, Australia. FAU - D'Souza, Wendyl AU - D'Souza W AD - Department of Medicine, St. Vincent's Hospital, The University of Melbourne, Fitzroy, VIC, Australia. FAU - Elder, Christopher J AU - Elder CJ AD - Division of Epilepsy and Sleep, Columbia University, New York, NY, United States. FAU - Farooque, Pue AU - Farooque P AD - Yale University School of Medicine, New Haven, CT, United States. FAU - Johnson, Emily L AU - Johnson EL AD - Johns Hopkins University School of Medicine, Baltimore, MD, United States. FAU - Barnard, Sarah AU - Barnard S AD - Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia. AD - Department of Neurology, Alfred Health, Melbourne, VIC, Australia. AD - Department of Neurology, New York University Grossman School of Medicine, New York, NY, United States. FAU - Nightscales, Russell AU - Nightscales R AD - Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia. AD - Department of Neurology, Alfred Health, Melbourne, VIC, Australia. AD - Department of Neurology, The Royal Melbourne Hospital, Melbourne, VIC, Australia. AD - Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, St Vincent's Hospital Melbourne, Melbourne, VIC, Australia. FAU - Kwan, Patrick AU - Kwan P AD - Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia. AD - Department of Neurology, Alfred Health, Melbourne, VIC, Australia. AD - Department of Neurology, The Royal Melbourne Hospital, Melbourne, VIC, Australia. AD - Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, St Vincent's Hospital Melbourne, Melbourne, VIC, Australia. FAU - Moseley, Brian AU - Moseley B AD - Clinical Development Neurocrine Biosciences Inc., San Diego, CA, United States. FAU - O'Brien, Terence J AU - O'Brien TJ AD - Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia. AD - Department of Neurology, Alfred Health, Melbourne, VIC, Australia. AD - Department of Neurology, The Royal Melbourne Hospital, Melbourne, VIC, Australia. AD - Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, St Vincent's Hospital Melbourne, Melbourne, VIC, Australia. FAU - Sivathamboo, Shobi AU - Sivathamboo S AD - Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia. AD - Department of Neurology, Alfred Health, Melbourne, VIC, Australia. AD - Department of Neurology, The Royal Melbourne Hospital, Melbourne, VIC, Australia. AD - Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, St Vincent's Hospital Melbourne, Melbourne, VIC, Australia. FAU - Laze, Juliana AU - Laze J AD - Comprehensive Epilepsy Center, New York University Langone Health, New York, NY, United States. FAU - Friedman, Daniel AU - Friedman D AD - Department of Neurology, New York University Grossman School of Medicine, New York, NY, United States. AD - Comprehensive Epilepsy Center, New York University Langone Health, New York, NY, United States. FAU - Devinsky, Orrin AU - Devinsky O AD - Neuroscience Institute, New York University Grossman School of Medicine, New York, NY, United States. AD - Department of Neurology, New York University Grossman School of Medicine, New York, NY, United States. AD - Comprehensive Epilepsy Center, New York University Langone Health, New York, NY, United States. CN - MS-BioS Study Group LA - eng GR - R01 NS123928/NS/NINDS NIH HHS/United States PT - Journal Article DEP - 20220318 PL - Switzerland TA - Front Neurol JT - Frontiers in neurology JID - 101546899 PMC - PMC8973318 OTO - NOTNLM OT - ECG OT - EEG OT - SUDEP OT - biomarker OT - machine learning COIS- ZC reports grants from the National Institutes of Health (NIH) and National Science Foundation (NSF) during the conduct of the study. ZC is also a founder and CEO of NeuroThX, LLC. ZC also received cloud computing resources supported by the Oracle for Research Award. DF receives salary support for consulting and clinical trial related activities performed on behalf of The Epilepsy Study Consortium, a non-profit organization. DF receives no personal income for these activities. NYU receives a fixed amount from the Epilepsy Study Consortium toward DF salary. Within the past two years, The Epilepsy Study Consortium received payments for research services performed by DF from: Alterity, Baergic, Biogen, BioXcell, Cerevel, Cerebral, Jannsen, Lundbeck, Neurocrine, SK Life Science, and Xenon. He has also served as a paid consultant for Neurelis Pharmaceuticals and Receptor Life Sciences. He has received travel support from the Epilepsy Foundation. He has received research support from NINDS, Epilepsy Foundation, Empatica, Epitel, UCB, Inc and Neuropace unrelated to this study. He serves on the scientific advisory board for Receptor Life Sciences. He holds equity interests in Neuroview Technology. He received royalty income from Oxford University Press. SB is supported by a Program Grant from the National Health and Medical Research Council of Australia (APP1091593). He reports grants from Eisai, UCB Pharma, and SciGen; has a patent for SCN1A licensed to various diagnostic companies with no financial return, a patent for PRRT2 gene licensed to Athena Diagnostics, and a patent for Diagnostic and Therapeutic Methods for Epilepsy and Mental Retardation Limited to Females (EFMR) licensed to Athena Diagnostics. PP is supported by an Early Career Fellowship from the National Health and Medical Research Council (APP1163708), the Epilepsy Foundation, The University of Melbourne, Monash University, Brain Australia, and the Weary Dunlop Medical Research Foundation. He has received speaker honoraria or consultancy fees to his institution from Chiesi, Eisai, the limbic, LivaNova, Novartis, Sun Pharma, Supernus, and UCB Pharma. He is an Associate Editor for Epilepsia Open. WD'S receives salary support from The University of Melbourne. He has received travel, investigator-initiated, scientific advisory board and speaker honoraria from UCB Pharma Australia & Global; investigator-initiated, scientific advisory board, travel and speaker honoraria from Eisai Australia & Global; advisory board honoraria from Liva Nova; educational grants from Novartis Pharmaceuticals, Pfizer Pharmaceuticals and Sanofi-Synthelabo; educational; travel and fellowship grants from GSK Neurology Australia, and honoraria from SciGen Pharmaceuticals. He has shareholdings in the device company EpiMinder. PK is supported by a Medical Research Future Fund from the National Health and Medical Research Council of Australia (MRF1136427) and the Victorian Medical Research Acceleration Fund. He reports grants and personal fees from Eisai, UCB Pharma, and LivaNova; reports grants from Zynerba, Biscayne, and GW Pharmaceuticals; and has received travel, speaker honoraria, or consultancy fees from Sun Pharmaceuticals, Supernus Pharmaceuticals, Novartis, and Eisai. BM is a paid employee at Clinical Development Neurocrine Biosciences Inc. BM has previously served as an advisory board member/consultant for Eisai and UCB Pharma and as a speaker for Eisai, LivaNova and UCB Pharma. He has previously received research support from GW Pharma, LivaNova, Nonin Medical, Inc, Sunovion and Xenon Pharmaceuticals. TO'B is supported by a Program Grant (APP1091593) and Investigator Grant (APP1176426) from the National Health and Medical Research Council of Australia and the Victorian Medical Research Acceleration Fund. He reports grants and consulting fees to his institution from Eisai, UCB Pharma, Praxis, Biogen, ES Therapeutics and Zynerba. SS is supported by a Bridging Postdoctoral Fellowship from Monash University (BPF20-3253672466) and the Victorian Medical Research Acceleration Fund. She reports salary support paid to her institution from Kaoskey and Optalert for clinical trial related activities; she receives no personal income for these activities. OD received grants from the NIH during the conduct of the study, and received funding from Finding A Cure for Epilepsy and Seizures (FACES) and has equity in Empatica.. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2022/04/05 06:00 MHDA- 2022/04/05 06:01 PMCR- 2022/03/18 CRDT- 2022/04/04 05:28 PHST- 2022/01/19 00:00 [received] PHST- 2022/02/08 00:00 [accepted] PHST- 2022/04/04 05:28 [entrez] PHST- 2022/04/05 06:00 [pubmed] PHST- 2022/04/05 06:01 [medline] PHST- 2022/03/18 00:00 [pmc-release] AID - 10.3389/fneur.2022.858333 [doi] PST - epublish SO - Front Neurol. 2022 Mar 18;13:858333. doi: 10.3389/fneur.2022.858333. eCollection 2022.