PMID- 35370956
OWN - NLM
STAT- MEDLINE
DCOM- 20220405
LR  - 20220519
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 13
DP  - 2022
TI  - A MEN1 Patient Presenting With Multiple Parathyroid Adenomas and Transient 
      Hypercortisolism: A Case Report and Literature Review.
PG  - 802453
LID - 10.3389/fendo.2022.802453 [doi]
LID - 802453
AB  - BACKGROUND: Multiple endocrine neoplasia type 1 (MEN1) is a hereditary endocrine 
      syndrome caused by mutations in MEN1 tumor suppressor gene. CASE PRESENTATION: A 
      53-year-old Chinese female was admitted to Division of Endocrinology, Tongji 
      Hospital, for hypercalcemic crisis. Increased level of parathyroid hormone (PTH) 
      was confirmed by laboratory tests, and imaging examination showed multiple 
      parathyroid adenomas. Based on gene analysis, the patient was diagnosed as MEN1 
      associated hyperparathyroidism (HPT) by gene analysis with c.1378C>T 
      (p.Arg460Ter) mutation in MEN1 gene. Her condition was complicated by transient 
      hypercortisolism, mammary mass and uterine leiomyoma. After subtotal 
      parathyroidectomy, PTH and serum calcium levels returned to normal. CONCLUSION: 
      HPT with multiple parathyroid adenomas is an indication of MEN1 gene mutation. 
      Serum cortisol and its circadian rhythm can be abnormal in the presence of 
      hypercalcemia and high PTH. These parameters can return to normal after 
      parathyroidectomy.
CI  - Copyright (c) 2022 Chen, Xu, Yue, Yu and Shao.
FAU - Chen, Fuqiong
AU  - Chen F
AD  - Division of Endocrinology, Tongji Hospital, Huazhong University of Science & 
      Technology, Wuhan, China.
AD  - Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, China.
FAU - Xu, Qinqin
AU  - Xu Q
AD  - Division of Endocrinology, Tongji Hospital, Huazhong University of Science & 
      Technology, Wuhan, China.
AD  - Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, China.
FAU - Yue, Wenzhu
AU  - Yue W
AD  - Division of Endocrinology, Tongji Hospital, Huazhong University of Science & 
      Technology, Wuhan, China.
AD  - Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, China.
FAU - Yu, Xuefeng
AU  - Yu X
AD  - Division of Endocrinology, Tongji Hospital, Huazhong University of Science & 
      Technology, Wuhan, China.
AD  - Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, China.
FAU - Shao, Shiying
AU  - Shao S
AD  - Division of Endocrinology, Tongji Hospital, Huazhong University of Science & 
      Technology, Wuhan, China.
AD  - Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, China.
LA  - eng
PT  - Case Reports
PT  - Review
DEP - 20220308
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
SB  - IM
MH  - *Cushing Syndrome/etiology/genetics
MH  - Female
MH  - Humans
MH  - *Hypercalcemia/complications
MH  - *Hyperparathyroidism
MH  - Middle Aged
MH  - *Multiple Endocrine Neoplasia Type 1/complications/diagnosis/genetics
MH  - *Parathyroid Neoplasms/complications/genetics/surgery
PMC - PMC8965320
OTO - NOTNLM
OT  - hypercalcemia
OT  - hypercortisolism
OT  - hyperparathyroidism
OT  - multiple endocrine neoplasia type 1
OT  - parathyroid adenomas
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/04/05 06:00
MHDA- 2022/04/06 06:00
PMCR- 2022/01/01
CRDT- 2022/04/04 05:28
PHST- 2021/11/16 00:00 [received]
PHST- 2022/01/21 00:00 [accepted]
PHST- 2022/04/04 05:28 [entrez]
PHST- 2022/04/05 06:00 [pubmed]
PHST- 2022/04/06 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2022.802453 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2022 Mar 8;13:802453. doi: 
      10.3389/fendo.2022.802453. eCollection 2022.