PMID- 35371594
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220405
IS  - 2152-5250 (Print)
IS  - 2152-5250 (Electronic)
IS  - 2152-5250 (Linking)
VI  - 13
IP  - 2
DP  - 2022 Apr
TI  - Novel Insights into the Roles and Mechanisms of GLP-1 Receptor Agonists against 
      Aging-Related Diseases.
PG  - 468-490
LID - 10.14336/AD.2021.0928 [doi]
AB  - Aging and aging-related diseases have emerged as increasingly severe health and 
      social problems. Therefore, it is imperative to discover novel and effective 
      therapeutics to delay the aging process and to manage aging-related diseases. 
      Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), one of the classes of 
      antihyperglycemic drugs, have been recommended to manage type 2 diabetes mellitus 
      (T2DM). Moreover, GLP-1 RAs have been shown to protect against oxidative stress, 
      cellular senescence and chronic inflammation, which are widely accepted as the 
      major risk factors of aging. However, their significance in aging or 
      aging-related diseases has not been elucidated. Herein, we explain the underlying 
      mechanisms and protective roles of GLP-1 RAs in aging from a molecular, cellular 
      and phenotypic perspective. We provide novel insights into the broad prospect of 
      GLP-1 RAs in preventing and treating aging-related diseases. Additionally, we 
      highlight the gaps for further studies in clinical applications of GLP-1 RAs in 
      aging-related diseases. This review forms a basis for further studies on the 
      relationship between aging-related diseases and GLP-1 RAs.
CI  - Copyright: (c) 2022 Peng et al.
FAU - Peng, Wei
AU  - Peng W
AD  - 1Department of Gastrointestinal Surgery, Hunan Provincial People's Hospital, The 
      First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China.
FAU - Zhou, Rui
AU  - Zhou R
AD  - 2Hunan Normal University School of Medicine, Changsha, Hunan, China.
FAU - Sun, Ze-Fang
AU  - Sun ZF
AD  - 2Hunan Normal University School of Medicine, Changsha, Hunan, China.
FAU - Long, Jia-Wei
AU  - Long JW
AD  - 2Hunan Normal University School of Medicine, Changsha, Hunan, China.
FAU - Gong, Yong-Qiang
AU  - Gong YQ
AD  - 1Department of Gastrointestinal Surgery, Hunan Provincial People's Hospital, The 
      First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220401
PL  - United States
TA  - Aging Dis
JT  - Aging and disease
JID - 101540533
PMC - PMC8947838
OTO - NOTNLM
OT  - GLP-1 receptor agonists
OT  - aging
OT  - aging-related diseases
OT  - glucagon-like peptide-1
COIS- Competing Interests The authors declare that they have no competing interests.
EDAT- 2022/04/05 06:00
MHDA- 2022/04/05 06:01
PMCR- 2022/04/01
CRDT- 2022/04/04 05:30
PHST- 2021/06/30 00:00 [received]
PHST- 2021/10/16 00:00 [accepted]
PHST- 2022/04/04 05:30 [entrez]
PHST- 2022/04/05 06:00 [pubmed]
PHST- 2022/04/05 06:01 [medline]
PHST- 2022/04/01 00:00 [pmc-release]
AID - ad-13-2-468 [pii]
AID - 10.14336/AD.2021.0928 [doi]
PST - epublish
SO  - Aging Dis. 2022 Apr 1;13(2):468-490. doi: 10.14336/AD.2021.0928. eCollection 2022 
      Apr.