PMID- 35371847
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220405
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 14
IP  - 3
DP  - 2022 Mar
TI  - Correlations Between Inflammatory Biomarkers in Tuberculosis-Associated 
      Obstructive Pulmonary Disease Patients With Anxiety and Depression.
PG  - e22742
LID - 10.7759/cureus.22742 [doi]
LID - e22742
AB  - Introduction Tuberculosis-associated obstructive pulmonary disease (TOPD), 
      anxiety, and depression are significant public health problems worldwide and 
      their prevalence is common. These diseases interfere with physical, psychosocial, 
      and economic well-being, resulting in unemployment, prolonged hospitalization, 
      abstinence from working, and isolation. Subjects and methods This is a 
      single-center, cross-sectional cohort, observational study conducted in a 
      tertiary care hospital over six years to understand spirometry, laboratory 
      profiles, as well as the impact on overall health, daily life, and perceived 
      well-being in patients with TOPD. Result The sample size of the study was 73 
      patients. A total of 43 (58.5%) patients had depression with an average St. 
      George's Respiratory Questionnaire for chronic obstructive pulmonary disease 
      (SGRQ-C) score of 67.5, and 16 (21.9%) patients had anxiety with an average 
      SGRQ-C score of 78.9. In the patients who scored higher on the Hamilton 
      Depression Rating Scale (HAM-D), there was a significant correlation between 
      Hamilton Anxiety Rating Scale (HAM-A) and HAM-D scores, as well as C-reactive 
      protein (CRP) levels and WBC counts. In 16 (21.9%) of the patients with moderate 
      to severe anxiety, there was a statistically significant negative correlation 
      between higher HAM-A scores and lower WBC counts. Anxiety, depression, CRP level, 
      WBC count, and serum fibrinogen did not show a significant correlation with the 
      Global Initiative for Chronic Obstructive Lung Disease (GOLD) groups-based 
      assessment of TOPD severity. A high serum fibrinogen level did not correlate with 
      a high HAM-D score, nor did a high CRP level correlate with a high HAM-A score. 
      Conclusion Psychiatric comorbidities like depression are associated with 
      increased inflammation in chronic diseases like TOPD, but no definitive biomarker 
      has been identified and further studies are required to identify suitable 
      biomarkers.
CI  - Copyright (c) 2022, Katare et al.
FAU - Katare, Srikanth
AU  - Katare S
AD  - Respiratory Medicine, Vydehi Institute of Medical Sciences and Research Centre, 
      Bengaluru, IND.
FAU - Harsha, Ajit
AU  - Harsha A
AD  - Respiratory Medicine, Vydehi Institute of Medical Sciences and Research Centre, 
      Bengaluru, IND.
LA  - eng
PT  - Journal Article
DEP - 20220301
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC8971095
OTO - NOTNLM
OT  - anxiety
OT  - bio-markers
OT  - combined gold copd assessment group
OT  - depression
OT  - hamilton anxiety rating scale (ham-a)
OT  - hamilton depression rating scale (ham-d)
OT  - tb -tuberculosis
OT  - topd- tuberculosis associated obstructive pulmonary disease
OT  - tuberculosis associated copd
COIS- The authors have declared that no competing interests exist.
EDAT- 2022/04/05 06:00
MHDA- 2022/04/05 06:01
PMCR- 2022/03/01
CRDT- 2022/04/04 05:31
PHST- 2022/03/01 00:00 [accepted]
PHST- 2022/04/04 05:31 [entrez]
PHST- 2022/04/05 06:00 [pubmed]
PHST- 2022/04/05 06:01 [medline]
PHST- 2022/03/01 00:00 [pmc-release]
AID - 10.7759/cureus.22742 [doi]
PST - epublish
SO  - Cureus. 2022 Mar 1;14(3):e22742. doi: 10.7759/cureus.22742. eCollection 2022 Mar.