PMID- 35372166
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220405
IS  - 2296-2360 (Print)
IS  - 2296-2360 (Electronic)
IS  - 2296-2360 (Linking)
VI  - 10
DP  - 2022
TI  - Early Immunomodulatory Effects of Different Natural Surfactant Preparations in 
      Preterms With Respiratory Distress.
PG  - 845780
LID - 10.3389/fped.2022.845780 [doi]
LID - 845780
AB  - BACKGROUND: Respiratory distress syndrome (RDS) is the most common respiratory 
      disease in premature infants. Exogenous natural surfactant preparations are used 
      in the treatment of RDS. In recent years, it has become increasingly evident that 
      surfactant plays an immunoregulatory role. OBJECTIVES: The aim of this study was 
      to evaluate cytokine and chemokine response following three different regimens of 
      natural surfactant treatment in preterm newborns with RDS. METHODS: Premature 
      newborns below 32 weeks of gestation who were intubated for RDS and given early 
      surfactant rescue therapy were included in the study. Newborns were randomly 
      divided into three groups and Beractant 100 mg/kg (B-100), Poractant alfa 100 
      mg/kg (Palpha-100) and Poractant alfa 200 mg/kg (Palpha-200) were administered 
      intratracheally. Blood samples and transtracheal aspirates (TA) were collected 
      just before and 4-6 h after the surfactant treatment. Total eosinophil count, 
      inducible T Cell alpha chemoattractant (ITaC), macrophage inflammatory protein 3 
      beta (MIP3b), interleukins (IL) 5, 8, 9, 10, 13, immunoglobulin E (IgE), 
      interferon gamma (IFN-gamma), eotaxin and tumor necrosis factor beta-1 (TGF-beta1) were 
      measured from blood and tracheal aspirate samples. RESULTS: A total of 45 
      infants, 15 in each group, were included in the study. Mean gestational age, 
      birth weight, antenatal, demographic and clinical characteristics of the study 
      groups were similar. IFNgamma concentration and eosinophil counts in TA decreased 
      after surfactant replacement in all groups, especially in the infants treated 
      with Palpha-100 and Palpha-200. Eotaxin, TGF beta and IL-8 concentrations in TA increased 
      significantly in the infants treated with Palpha-100 and Palpha-200. IL-9 levels in TA 
      decreased in the B-100 group but increased in the Palpha-100 and Palpha-200 groups. Blood 
      levels of cytokines and chemokines showed significantly decreased levels of ITaC 
      and MIP3b only in the B-100 group, but no significant change was observed in the 
      Palpha-100 and Palpha-200 groups. CONCLUSION: In our study, the different 
      immunomodulatory effects of natural surfactant preparations on newborn lung is 
      proven. We found that Poractant alpha, one of the natural surfactant preparations, 
      shifted the lung immune system toward TH2.
CI  - Copyright (c) 2022 Yalaz, Tanriverdi, Uygur, Altun Koroglu, Azarsiz, Aksu and 
      Kultursay.
FAU - Yalaz, Mehmet
AU  - Yalaz M
AD  - Department of Pediatrics, Division of Neonatology, Ege University Medical School, 
      Izmir, Turkey.
FAU - Tanriverdi, Sema
AU  - Tanriverdi S
AD  - Department of Pediatrics, Division of Neonatology, Manisa Celal Bayar University 
      Medical School, Manisa, Turkey.
FAU - Uygur, Ozgun
AU  - Uygur O
AD  - Department of Pediatrics, Division of Neonatology, Izmir Tepecik Training and 
      Research Hospital, Izmir, Turkey.
FAU - Altun Koroglu, Ozge
AU  - Altun Koroglu O
AD  - Department of Pediatrics, Division of Neonatology, Ege University Medical School, 
      Izmir, Turkey.
FAU - Azarsiz, Elif
AU  - Azarsiz E
AD  - Department of Pediatrics, Division of Pediatric Immunology, Ege University 
      Medical School, Izmir, Turkey.
FAU - Aksu, Guzide
AU  - Aksu G
AD  - Department of Pediatrics, Division of Pediatric Immunology, Ege University 
      Medical School, Izmir, Turkey.
FAU - Kultursay, Nilgun
AU  - Kultursay N
AD  - Department of Pediatrics, Division of Neonatology, Ege University Medical School, 
      Izmir, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20220318
PL  - Switzerland
TA  - Front Pediatr
JT  - Frontiers in pediatrics
JID - 101615492
PMC - PMC8971705
OTO - NOTNLM
OT  - immune response
OT  - newborn
OT  - prematurity
OT  - respiratory distress syndrome
OT  - surfactant
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/04/05 06:00
MHDA- 2022/04/05 06:01
PMCR- 2022/03/18
CRDT- 2022/04/04 05:32
PHST- 2021/12/30 00:00 [received]
PHST- 2022/02/22 00:00 [accepted]
PHST- 2022/04/04 05:32 [entrez]
PHST- 2022/04/05 06:00 [pubmed]
PHST- 2022/04/05 06:01 [medline]
PHST- 2022/03/18 00:00 [pmc-release]
AID - 10.3389/fped.2022.845780 [doi]
PST - epublish
SO  - Front Pediatr. 2022 Mar 18;10:845780. doi: 10.3389/fped.2022.845780. eCollection 
      2022.