PMID- 35378399
OWN - NLM
STAT- MEDLINE
DCOM- 20220428
LR  - 20220428
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 236
DP  - 2022 May 1
TI  - Influence of perinatal deltamethrin exposure at distinct developmental stages on 
      motor activity, learning and memory.
PG  - 113460
LID - S0147-6513(22)00300-1 [pii]
LID - 10.1016/j.ecoenv.2022.113460 [doi]
AB  - BACKGROUND: Perinatal exposure to deltamethrin (DM) causes attention-deficit/ 
      hyperactivity disorder-like behaviors. However, the vulnerable time window to DM 
      exposure and the possible mechanism are obscure. We aimed to identify the 
      critical window(s) at perinatal stages for DM exposure and the possible 
      mechanism. METHOD: Pregnant mice were exposed to DM (0.5 mg/kg) at three 
      different prenatal stages [gestational day (GD) 0-5, 6-15 and 16-birth (16-B)] 
      and early postnatal stage (PD 0-10). Locomotor activity, learning and memory were 
      evaluated using open field and Y-maze test, respectively. Nissl staining and 
      western blots were used to examine the neuronal loss and the protein expression, 
      respectively. RESULTS: Perinatal exposures to DM had no effect on reproductive 
      and growth index of offspring. However, mice receiving DM exposure during GD 16-B 
      displayed significantly higher mortality suggesting GD 16-B is the most 
      vulnerable time window to DM exposure. Prenatal but not early postnatal DM 
      exposure impaired locomotor activity, learning and memory, and caused neuron loss 
      in the dentate gyrus of male offspring. However, neither prenatal nor postnatal 
      DM exposure affected mouse behavior of female offspring. Prenatal DM exposures 
      decreased the protein levels of NR2A and NR2B in both hippocampi and cerebral 
      cortices of male offspring. However, female mice receiving DM exposure at GD 16-B 
      but not other stages displayed increased expression levels of NR2A and NR2B in 
      hippocampi. CONCLUSION: Prenatal but not early postnatal DM exposure impairs the 
      neuron development in male but not female mice. Altered NMDA receptor expression 
      may correlate to DM-induced behavioral deficits.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Xi, Chuchu
AU  - Xi C
AD  - Department of TCM Pharmacology, School of Traditional Chinese Pharmacy, China 
      Pharmaceutical University, Nanjing, Jiangsu 211198, PR China. Electronic address: 
      xichuchu0917@stu.cpu.edu.cn.
FAU - Yang, Zhao
AU  - Yang Z
AD  - Department of TCM Pharmacology, School of Traditional Chinese Pharmacy, China 
      Pharmaceutical University, Nanjing, Jiangsu 211198, PR China. Electronic address: 
      yangzhao0115@stu.cpu.edu.cn.
FAU - Yu, Yiyi
AU  - Yu Y
AD  - Department of TCM Pharmacology, School of Traditional Chinese Pharmacy, China 
      Pharmaceutical University, Nanjing, Jiangsu 211198, PR China. Electronic address: 
      1721020312@cpu.edu.cn.
FAU - Li, Shaoheng
AU  - Li S
AD  - Department of TCM Pharmacology, School of Traditional Chinese Pharmacy, China 
      Pharmaceutical University, Nanjing, Jiangsu 211198, PR China. Electronic address: 
      lishaoheng0402@stu.cpu.edu.cn.
FAU - He, Jing
AU  - He J
AD  - Department of TCM Pharmacology, School of Traditional Chinese Pharmacy, China 
      Pharmaceutical University, Nanjing, Jiangsu 211198, PR China. Electronic address: 
      Hejing0902@stu.cpu.edu.cn.
FAU - El-Aziz, Tarek Mohamed Abd
AU  - El-Aziz TMA
AD  - Zoology Department, Faculty of Science, Minia University, El-Minia 61519, Egypt; 
      Department of Cellular and Integrative Physiology, University of Texas Health 
      Science Center at San Antonio, San Antonio, TX 78229-3900, USA. Electronic 
      address: mohamedt1@uthscsa.edu.
FAU - Zhao, Fang
AU  - Zhao F
AD  - Department of TCM Pharmacology, School of Traditional Chinese Pharmacy, China 
      Pharmaceutical University, Nanjing, Jiangsu 211198, PR China. Electronic address: 
      zhaofang0927@cpu.edu.cn.
FAU - Cao, Zhengyu
AU  - Cao Z
AD  - Department of TCM Pharmacology, School of Traditional Chinese Pharmacy, China 
      Pharmaceutical University, Nanjing, Jiangsu 211198, PR China. Electronic address: 
      zycao@cpu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20220401
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Nitriles)
RN  - 0 (Pyrethrins)
RN  - 2JTS8R821G (decamethrin)
SB  - IM
MH  - Animals
MH  - Female
MH  - Hippocampus
MH  - Humans
MH  - Male
MH  - Maze Learning
MH  - Mice
MH  - Motor Activity
MH  - Nitriles
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects/chemically induced/metabolism
MH  - Pyrethrins
OTO - NOTNLM
OT  - Deltamethrin
OT  - Learning and memory
OT  - Locomotor activity
OT  - NMDA receptor
OT  - Perinatal exposure
EDAT- 2022/04/05 06:00
MHDA- 2022/04/29 06:00
CRDT- 2022/04/04 20:13
PHST- 2022/01/24 00:00 [received]
PHST- 2022/03/12 00:00 [revised]
PHST- 2022/03/25 00:00 [accepted]
PHST- 2022/04/05 06:00 [pubmed]
PHST- 2022/04/29 06:00 [medline]
PHST- 2022/04/04 20:13 [entrez]
AID - S0147-6513(22)00300-1 [pii]
AID - 10.1016/j.ecoenv.2022.113460 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2022 May 1;236:113460. doi: 10.1016/j.ecoenv.2022.113460. 
      Epub 2022 Apr 1.