PMID- 35379557
OWN - NLM
STAT- MEDLINE
DCOM- 20220511
LR  - 20220511
IS  - 1424-3911 (Electronic)
IS  - 1424-3903 (Linking)
VI  - 22
IP  - 4
DP  - 2022 May
TI  - HLA-DRB1 *16 and -DQB1 *05 alleles are strongly associated with autoimmune 
      pancreatitis in a cohort of hundred patients.
PG  - 466-471
LID - S1424-3903(22)00104-1 [pii]
LID - 10.1016/j.pan.2022.03.015 [doi]
AB  - BACKGROUND/OBJECTIVES: Autoimmune diseases are often associated with human 
      leukocyte antigen (HLA) haplotypes, indicating that changes in major 
      histocompatibility complex (MHC)-dependent self-peptide or antigen presentation 
      contribute to autoimmunity. In our study, we aimed to investigate HLA alleles in 
      a large European cohort of autoimmune pancreatitis (AIP) patients. METHODS: 
      Hundred patients with AIP, diagnosed and classified according to the 
      International Consensus Diagnostic Criteria (ICDC), were prospectively enrolled 
      in the study. Forty-four patients with chronic pancreatitis (CP) and 254 healthy 
      subjects served as control groups. DNA was isolated from blood samples and 
      two-digit HLA typing was performed with sequence-specific primer (SSP-) PCR. HLA 
      allele association strength to AIP was calculated as odds ratio. RESULTS: We 
      uncovered a strong enrichment of HLA-DQB1 homozygosity in type 1 and type 2 AIP 
      patients. Moreover, a significantly increased incidence of the HLA-DRB1 *16 and 
      HLA-DQB1 *05 alleles and a concomitant lack of the HLA-DRB1 *13 allele was detected 
      in AIP type 1 and type 2 patients. In contrast, the HLA-DQB1 *02 allele was 
      underrepresented in the 'not otherwise specified' (NOS) AIP subtype. We detected 
      no significant difference in the HLA-DRB3, HLA-DRB4 and HLA-DRB5 allele frequency 
      in our cohort. CONCLUSIONS: Although AIP type 1 and type 2 are characterized by 
      distinct histopathological characteristics, both subtypes are associated with the 
      same HLA alleles, indicating that the disease might rely on similar immunogenic 
      mechanisms. However, AIP NOS represented another subclass of AIP.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Goni, Elisabetta
AU  - Goni E
AD  - Department of Medicine II, University Hospital, LMU, Munich, Germany.
FAU - Regel, Ivonne
AU  - Regel I
AD  - Department of Medicine II, University Hospital, LMU, Munich, Germany. Electronic 
      address: ivonne.regel@med.uni-muenchen.de.
FAU - Mahajan, Ujjwal Mukund
AU  - Mahajan UM
AD  - Department of Medicine II, University Hospital, LMU, Munich, Germany.
FAU - Amodio, Antonio
AU  - Amodio A
AD  - Department of Medicine, Pancreas Center, University of Verona, Verona, Italy.
FAU - De Marchi, Giulia
AU  - De Marchi G
AD  - Department of Medicine, Pancreas Center, University of Verona, Verona, Italy.
FAU - Beyer, Georg
AU  - Beyer G
AD  - Department of Medicine II, University Hospital, LMU, Munich, Germany.
FAU - Zuppardo, Raffaella Alessia
AU  - Zuppardo RA
AD  - Gastroenterology and Gastrointestinal Endoscopy, Division of Experimental 
      Oncology, Vita-Salute San Raffaele University, Milan, Italy.
FAU - Di Leo, Milena
AU  - Di Leo M
AD  - Gastroenterology and Gastrointestinal Endoscopy, Division of Experimental 
      Oncology, Vita-Salute San Raffaele University, Milan, Italy.
FAU - Lanzillotta, Marco
AU  - Lanzillotta M
AD  - Unit of Immunology, Rheumatology, Allergy and Rare Diseases, uniRAR, IRCCS San 
      Raffaele Scientific Institute, Milan, Italy.
FAU - Bonatti, Francesco
AU  - Bonatti F
AD  - Department of Medicine and Surgery, Medical Genetics Unit, University of Parma, 
      Italy.
FAU - Kauke, Teresa
AU  - Kauke T
AD  - Division of Transfusion Medicine, Cellular Therapeutics and Hemostaseology, 
      University Clinic LMU, Munich, Germany.
FAU - Dick, Andrea
AU  - Dick A
AD  - Division of Transfusion Medicine, Cellular Therapeutics and Hemostaseology, 
      University Clinic LMU, Munich, Germany.
FAU - Weiss, Frank Ulrich
AU  - Weiss FU
AD  - Department of Medicine A, University Medicine Greifswald, Greifswald, Germany.
FAU - Schonermarck, Ulf
AU  - Schonermarck U
AD  - Department of Medicine IV, University Hospital, LMU, Munich, Germany.
FAU - Lerch, Markus M
AU  - Lerch MM
AD  - Department of Medicine A, University Medicine Greifswald, Greifswald, Germany.
FAU - Frulloni, Luca
AU  - Frulloni L
AD  - Department of Medicine, Pancreas Center, University of Verona, Verona, Italy.
FAU - Cavestro, Giulia Martina
AU  - Cavestro GM
AD  - Gastroenterology and Gastrointestinal Endoscopy, Division of Experimental 
      Oncology, Vita-Salute San Raffaele University, Milan, Italy.
FAU - Mayerle, Julia
AU  - Mayerle J
AD  - Department of Medicine II, University Hospital, LMU, Munich, Germany.
LA  - eng
PT  - Journal Article
DEP - 20220321
PL  - Switzerland
TA  - Pancreatology
JT  - Pancreatology : official journal of the International Association of 
      Pancreatology (IAP) ... [et al.]
JID - 100966936
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB4 Chains)
SB  - IM
MH  - Alleles
MH  - *Autoimmune Pancreatitis
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA-DRB1 Chains/genetics
MH  - HLA-DRB4 Chains/genetics
MH  - Haplotypes
MH  - Humans
OTO - NOTNLM
OT  - AIP subtypes
OT  - Autoimmune pancreatitis
OT  - Caucasian population
OT  - HLA class II genes
OT  - HLA typing
EDAT- 2022/04/06 06:00
MHDA- 2022/05/12 06:00
CRDT- 2022/04/05 05:30
PHST- 2021/12/03 00:00 [received]
PHST- 2022/03/18 00:00 [revised]
PHST- 2022/03/19 00:00 [accepted]
PHST- 2022/04/06 06:00 [pubmed]
PHST- 2022/05/12 06:00 [medline]
PHST- 2022/04/05 05:30 [entrez]
AID - S1424-3903(22)00104-1 [pii]
AID - 10.1016/j.pan.2022.03.015 [doi]
PST - ppublish
SO  - Pancreatology. 2022 May;22(4):466-471. doi: 10.1016/j.pan.2022.03.015. Epub 2022 
      Mar 21.