PMID- 35381889
OWN - NLM
STAT- MEDLINE
DCOM- 20220531
LR  - 20220531
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Linking)
VI  - 59
IP  - 6
DP  - 2022 Jun
TI  - Gestational and Lactational Iron Deficiency Anemia Impairs Myelination and the 
      Neurovascular Unit in Infant Rats.
PG  - 3738-3754
LID - 10.1007/s12035-022-02798-3 [doi]
AB  - Iron deficiency anemia is a prevalent health problem among pregnant women and 
      infants, particularly in the developing countries that causes brain development 
      deficits and poor cognitive outcomes. Since tissue iron depletion may impair 
      myelination and trigger cellular hypoxic signaling affecting blood vessels, we 
      studied myelination and the neurovascular unit (NVU) in infant rats born to 
      mothers fed with an iron deficient (ID) or control diet from embryonic day 5 till 
      weaning. Blood samples and brains of rat pups at postnatal day (PND) 14 and 30 
      were analyzed. PND 14 ID rats had severe microcytic hypochromic anemia that was 
      almost reversed at PND 30 although hypomyelination and astrocyte immature 
      phenotype in the corpus callosum were significant at that age. In CA1 hippocampal 
      region, PND 14 and PND 30 ID rats showed significant reduced expression of the 
      receptor beta of the platelet-derived growth factor localized in pericytes and 
      associated to aquaporin 4 (AQP4) immunopositive capillaries. Shorter 
      AQP4 + capillaries and reduced AQP4 expression were also evidenced in PND 14 and 
      PND 30 ID rats. In addition, pericyte membrane permeability through large-pore 
      channels was transiently increased in ID rats at PND 14 but not at PND 30, while 
      the blood-brain barrier permeability was not affected. Remarkably, transient 
      increased pericyte permeability found in PND 14 ID rats was not directly related 
      to iron depletion, suggesting the involvement of other iron deficiency 
      anemia-induced mechanisms. In summary, severe ID during gestation and lactation 
      produces persistent hypomyelination and significantly affects hippocampal 
      pericytes and astrocytes in the NVU which may trigger impaired neurovascular 
      function.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Isasi, Eugenia
AU  - Isasi E
AD  - Neurobiologia Celular y Molecular, Instituto de Investigaciones Biologicas 
      Clemente Estable (IIBCE), 3318, Italia Av., 11600, Montevideo, Uruguay.
AD  - Neurobiologia Celular y Molecular, Departamento de Histologia y Embriologia, 
      Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay.
FAU - Figares, Martin
AU  - Figares M
AD  - Neurobiologia Celular y Molecular, Departamento de Histologia y Embriologia, 
      Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay.
AD  - Departamento de Fisiologia, Facultad de Medicina, Universidad de la Republica, 
      Montevideo, Uruguay.
FAU - Abudara, Veronica
AU  - Abudara V
AD  - Departamento de Fisiologia, Facultad de Medicina, Universidad de la Republica, 
      Montevideo, Uruguay.
FAU - Olivera-Bravo, Silvia
AU  - Olivera-Bravo S
AUID- ORCID: 0000-0002-6483-1466
AD  - Neurobiologia Celular y Molecular, Instituto de Investigaciones Biologicas 
      Clemente Estable (IIBCE), 3318, Italia Av., 11600, Montevideo, Uruguay. 
      solivera2011@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20220406
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - *Anemia, Iron-Deficiency/complications/metabolism
MH  - Animals
MH  - Animals, Newborn
MH  - Female
MH  - Hippocampus/metabolism
MH  - Humans
MH  - Iron/metabolism
MH  - *Iron Deficiencies
MH  - Lactation
MH  - Pregnancy
MH  - Rats
OTO - NOTNLM
OT  - Anemia
OT  - Aquaporin 4
OT  - Astrocytes
OT  - Hippocampus
OT  - Iron deficiency
OT  - Pericytes
OT  - Receptor beta of the platelet-derived growth factor
EDAT- 2022/04/07 06:00
MHDA- 2022/06/01 06:00
CRDT- 2022/04/06 05:05
PHST- 2021/08/05 00:00 [received]
PHST- 2022/03/09 00:00 [accepted]
PHST- 2022/04/07 06:00 [pubmed]
PHST- 2022/06/01 06:00 [medline]
PHST- 2022/04/06 05:05 [entrez]
AID - 10.1007/s12035-022-02798-3 [pii]
AID - 10.1007/s12035-022-02798-3 [doi]
PST - ppublish
SO  - Mol Neurobiol. 2022 Jun;59(6):3738-3754. doi: 10.1007/s12035-022-02798-3. Epub 
      2022 Apr 6.