PMID- 35382071
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2158-8333 (Print)
IS  - 2158-8341 (Electronic)
IS  - 2158-8333 (Linking)
VI  - 19
IP  - 1-3
DP  - 2022 Jan-Mar
TI  - Toward Improving Functional Recovery in AIDS-associated Progressive Multifocal 
      Leukoencephalopathy: A Single Case Pilot Study on a Novel Neuromodulation 
      Approach.
PG  - 15-18
AB  - Patients with progressive multifocal leukoencephalopathy (PML) in the context of 
      human immunodeficiency virus-acquired immunodeficiency syndrome (HIV-AIDS) show a 
      partial improvement following rehabilitation; however, this improvement is 
      rapidly lost if the patient is not provided with intensive rehabilitation. A 
      42-year-old patient affected by HIV-AIDS had a clinical worsening within a few 
      months following PML onset, despite being treated with antiretroviral drugs and 
      conventional rehabilitation. He developed severe paraparesis and significant 
      dependency in the activities of daily life. A first cycle of intensive 
      rehabilitation provided the patient with some significant functional outcomes, 
      although he experienced a worsening of the clinical condition after two months of 
      rest, before admission to our rehabilitation unit. We thus sought to evaluate the 
      effects of intensive robot-aided gait training (RAGT) coupled with transcranial 
      direct current stimulation (tDCS). The patient significantly improved when 
      provided with intensive RAGT coupled with tDCS (as per 10-meter Walk Test [10MWT] 
      and 6-minute Walk Test [6MWT]), and the improvement was maintained at three-month 
      follow-up. As this advanced approach was feasible, safe, and potentially 
      effective, this case suggests that patients with PML-HIV require prolonged 
      multidisciplinary rehabilitation treatment. We can speculate that individuals 
      with PML should also be treated with innovative technology to improve their 
      functional outcomes and therefore quality of life.
CI  - Copyright (c) 2022. Matrix Medical Communications. All rights reserved.
FAU - Naro, Antonino
AU  - Naro A
AD  - Drs. Naro and Calabro, Ms. Billeri, Ms. Lauria, and Mr. Manuli are with IRCCS 
      Centro Neurolesi Bonino Pulejo-Piemonte in Messina, Italy.
FAU - Billeri, Luana
AU  - Billeri L
AD  - Drs. Naro and Calabro, Ms. Billeri, Ms. Lauria, and Mr. Manuli are with IRCCS 
      Centro Neurolesi Bonino Pulejo-Piemonte in Messina, Italy.
FAU - Lauria, Paola
AU  - Lauria P
AD  - Drs. Naro and Calabro, Ms. Billeri, Ms. Lauria, and Mr. Manuli are with IRCCS 
      Centro Neurolesi Bonino Pulejo-Piemonte in Messina, Italy.
FAU - Manuli, Alfredo
AU  - Manuli A
AD  - Drs. Naro and Calabro, Ms. Billeri, Ms. Lauria, and Mr. Manuli are with IRCCS 
      Centro Neurolesi Bonino Pulejo-Piemonte in Messina, Italy.
FAU - Calabro, Rocco Salvatore
AU  - Calabro RS
AD  - Drs. Naro and Calabro, Ms. Billeri, Ms. Lauria, and Mr. Manuli are with IRCCS 
      Centro Neurolesi Bonino Pulejo-Piemonte in Messina, Italy.
LA  - eng
PT  - Case Reports
PL  - United States
TA  - Innov Clin Neurosci
JT  - Innovations in clinical neuroscience
JID - 101549695
PMC - PMC8970235
OTO - NOTNLM
OT  - Progressive multifocal leukoencephalopathy
OT  - human immunodeficiency virus
OT  - robot-aided gait training
OT  - transcranial direct current stimulation
COIS- DISCLOSURES: The authors have no conflicts of interest relevant to the content of 
      this article.
EDAT- 2022/04/07 06:00
MHDA- 2022/04/07 06:01
PMCR- 2022/01/01
CRDT- 2022/04/06 05:10
PHST- 2022/04/06 05:10 [entrez]
PHST- 2022/04/07 06:00 [pubmed]
PHST- 2022/04/07 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
PST - ppublish
SO  - Innov Clin Neurosci. 2022 Jan-Mar;19(1-3):15-18.