PMID- 35382755
OWN - NLM
STAT- MEDLINE
DCOM- 20220407
LR  - 20220531
IS  - 1471-2334 (Electronic)
IS  - 1471-2334 (Linking)
VI  - 22
IP  - 1
DP  - 2022 Apr 6
TI  - Interleukin-6 and granulocyte colony-stimulating factor as predictors of the 
      prognosis of influenza-associated pneumonia.
PG  - 343
LID - 10.1186/s12879-022-07321-6 [doi]
LID - 343
AB  - BACKGROUND: Pneumonia is a common complication of influenza and closely related 
      to mortality in influenza patients. The present study examines cytokines as 
      predictors of the prognosis of influenza-associated pneumonia. METHODS: This 
      study included 101 inpatients with influenza (64 pneumonia and 37 non-pneumonia 
      patients). 48 cytokines were detected in the serum samples of the patients and 
      the clinical characteristics were analyzed. The correlation between them was 
      analyzed to identify predictive biomarkers for the prognosis of 
      influenza-associated pneumonia. RESULTS: Seventeen patients had poor prognosis 
      and developed pneumonia. Among patients with influenza-associated pneumonia, the 
      levels of 8 cytokines were significantly higher in those who had a poor 
      prognosis: interleukin-6 (IL-6), interferon-gamma (IFN-gamma), granulocyte 
      colony-stimulating factor (G-CSF), monocyte colony-stimulating factor (M-CSF), 
      monocyte chemoattractant protein-1 (MCP-1), monocyte chemoattractant protein-3, 
      Interleukin-2 receptor subunit alpha and Hepatocyte growth factor. Correlation 
      analysis showed that the IL-6, G-CSF, M-CSF, IFN-gamma, and MCP-1 levels had positive 
      correlations with the severity of pneumonia. IL-6 and G-CSF showed a strong and 
      positive correlation with poor prognosis in influenza-associated pneumonia 
      patients. The combined effect of the two cytokines resulted in the largest area 
      (0.926) under the receiver-operating characteristic curve. CONCLUSION: The 
      results indicate that the probability of poor prognosis in influenza patients 
      with pneumonia is significantly increased. IL-6, G-CSF, M-CSF, IFN-gamma, and MCP-1 
      levels had a positive correlation with the severity of pneumonia. Importantly, 
      IL-6 and G-CSF were identified as significant predictors of the severity of 
      influenza-associated pneumonia.
CI  - (c) 2022. The Author(s).
FAU - Zhang, Jiaying
AU  - Zhang J
AD  - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National 
      Clinical Research Center for Infectious Diseases, Collaborative Innovation Center 
      for Diagnosis and Treatment of Infectious Diseases, The First Affiliated 
      Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, People's 
      Republic of China.
FAU - Wang, Jingxia
AU  - Wang J
AD  - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National 
      Clinical Research Center for Infectious Diseases, Collaborative Innovation Center 
      for Diagnosis and Treatment of Infectious Diseases, The First Affiliated 
      Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, People's 
      Republic of China.
FAU - Gong, Yiwen
AU  - Gong Y
AD  - Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, 
      Hangzhou, 310000, People's Republic of China.
FAU - Gu, Yudan
AU  - Gu Y
AD  - Zhejiang Chinese Medical University, Hangzhou, 310000, China.
FAU - Xiang, Qiangqiang
AU  - Xiang Q
AD  - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National 
      Clinical Research Center for Infectious Diseases, Collaborative Innovation Center 
      for Diagnosis and Treatment of Infectious Diseases, The First Affiliated 
      Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, People's 
      Republic of China.
AD  - Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University, Shulan 
      International Medical College, Hangzhou, 310000, People's Republic of China.
FAU - Tang, Ling-Ling
AU  - Tang LL
AD  - State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National 
      Clinical Research Center for Infectious Diseases, Collaborative Innovation Center 
      for Diagnosis and Treatment of Infectious Diseases, The First Affiliated 
      Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, People's 
      Republic of China. lingling.tang@shulan.com.
AD  - Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University, Shulan 
      International Medical College, Hangzhou, 310000, People's Republic of China. 
      lingling.tang@shulan.com.
LA  - eng
GR  - 81872672/the National Natural Science Foundation of China Program/
GR  - 81872672/the National Natural Science Foundation of China Program/
GR  - 81872672/the National Natural Science Foundation of China Program/
GR  - 81872672/the National Natural Science Foundation of China Program/
GR  - 81872672/the National Natural Science Foundation of China Program/
GR  - 81872672/the National Natural Science Foundation of China Program/
GR  - 2017ZX10204401/the National Science and Technology Major Project/
GR  - 2017ZX10204401/the National Science and Technology Major Project/
GR  - 2017ZX10204401/the National Science and Technology Major Project/
GR  - 2017ZX10204401/the National Science and Technology Major Project/
GR  - 2017ZX10204401/the National Science and Technology Major Project/
GR  - 2017ZX10204401/the National Science and Technology Major Project/
GR  - 2020YFE0204300/the National High Technology Research and Development Program of 
      China/
PT  - Journal Article
DEP - 20220406
PL  - England
TA  - BMC Infect Dis
JT  - BMC infectious diseases
JID - 100968551
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
RN  - 143011-72-7 (Granulocyte Colony-Stimulating Factor)
SB  - IM
MH  - Cytokines/blood
MH  - *Granulocyte Colony-Stimulating Factor/blood
MH  - Humans
MH  - *Influenza, Human/complications/immunology
MH  - *Interleukin-6/blood
MH  - *Pneumonia, Viral/diagnosis/immunology
MH  - Prognosis
PMC - PMC8983324
OTO - NOTNLM
OT  - Cytokine
OT  - Granulocyte colony-stimulating factor
OT  - Influenza
OT  - Interleukin-6
OT  - Neutrophil
OT  - Pneumonia
COIS- The author reports no conflicts of interest in this work.
EDAT- 2022/04/07 06:00
MHDA- 2022/04/08 06:00
PMCR- 2022/04/06
CRDT- 2022/04/06 05:21
PHST- 2021/12/05 00:00 [received]
PHST- 2022/03/28 00:00 [accepted]
PHST- 2022/04/06 05:21 [entrez]
PHST- 2022/04/07 06:00 [pubmed]
PHST- 2022/04/08 06:00 [medline]
PHST- 2022/04/06 00:00 [pmc-release]
AID - 10.1186/s12879-022-07321-6 [pii]
AID - 7321 [pii]
AID - 10.1186/s12879-022-07321-6 [doi]
PST - epublish
SO  - BMC Infect Dis. 2022 Apr 6;22(1):343. doi: 10.1186/s12879-022-07321-6.