PMID- 35383049
OWN - NLM
STAT- MEDLINE
DCOM- 20230724
LR  - 20230724
IS  - 1468-2079 (Electronic)
IS  - 0007-1161 (Print)
IS  - 0007-1161 (Linking)
VI  - 107
IP  - 8
DP  - 2023 Aug
TI  - Retinal nerve fibre layer thickness measured with SD-OCT in a population-based 
      study: the Handan Eye Study.
PG  - 1156-1164
LID - 10.1136/bjophthalmol-2021-320618 [doi]
AB  - PURPOSE: To examine the normative profile of retinal nerve fibre layer (RNFL) 
      thickness and ocular parameters based on spectral-domain optical coherence 
      tomography (SD-OCT) and its associations with related parameters among the 
      Chinese population. METHODS: This population-based cohort Handan Eye Study (HES) 
      recruited participants aged>/=30 years. All subjects underwent a standardised 
      ophthalmic examination. Peripapillary RNFL thickness was obtained using SD-OCT. 
      Mixed linear models were adopted to evaluate the correlation of RNFL thickness 
      with ocular parameters as well as systemic factors. R V.3.6.1 software was used 
      for statistical analysis. RESULTS: 3509 subjects (7024 eyes) with the average age 
      of 55.54+/-10.37 were collected in this analysis. Overall mean RNFL thickness 
      measured was 113.46+/-10.90 microm, and the thickest quadrant of parapapillary RNFL was 
      the inferior quadrant, followed by the superior quadrant, the nasal quadrant and 
      the temporal quadrant. In the multivariate linear regression model, thinner RNFL 
      thickness was remarkable association with male (p<0.001), older age (p<0.001), 
      increased body mass index (>30, p=0.018), absence of diabetes (p=0.009), history 
      of cataract surgery (p=0.001), higher intraocular pressure (p=0.007), lower 
      spherical equivalent (p<0.001) and increased axial length (p=0.048). CONCLUSIONS: 
      In non-glaucoma individuals, this difference of RNFL thickness in Chinese 
      population should be noted in making disease diagnoses. Meanwhile, multiple 
      ocular and systemic factors are closely related to the thickness of RNFL. Our 
      findings further emphasise the need to demonstrate ethnic differences in RNFL 
      thickness and the specificity of associated ocular and systemic factors, as well 
      as to develop better normative databases worldwide. TRIAL REGISTRATION NUMBER: 
      HES was registered in Chinese Clinical Trial Registry website, and the registry 
      number was ChiCTR-EOC-17013214.
CI  - (c) Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published 
      by BMJ.
FAU - Wu, Jian
AU  - Wu J
AD  - Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren 
      Hospital, Capital Medical University; Beijing Ophthalmology & Visual Sciences Key 
      Laboratory, Beijing, China.
AD  - Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, 
      California, USA.
FAU - Du, Yifan
AU  - Du Y
AUID- ORCID: 0000-0002-6823-2719
AD  - Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren 
      Hospital, Capital Medical University; Beijing Ophthalmology & Visual Sciences Key 
      Laboratory, Beijing, China.
FAU - Lin, Caixia
AU  - Lin C
AD  - Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren 
      Hospital, Capital Medical University; Beijing Ophthalmology & Visual Sciences Key 
      Laboratory, Beijing, China.
FAU - Zhu, Yingting
AU  - Zhu Y
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Chen, Wei
AU  - Chen W
AD  - Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, 
      California, USA.
FAU - Pan, Qing
AU  - Pan Q
AD  - Department of Epidemiology and Biostatistics, West China School of Public Health 
      and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
FAU - Zhuo, Yehong
AU  - Zhuo Y
AUID- ORCID: 0000-0003-3247-7199
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Wang, Ningli
AU  - Wang N
AUID- ORCID: 0000-0002-8933-4482
AD  - Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren 
      Hospital, Capital Medical University; Beijing Ophthalmology & Visual Sciences Key 
      Laboratory, Beijing, China wningli@vip.163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220405
PL  - England
TA  - Br J Ophthalmol
JT  - The British journal of ophthalmology
JID - 0421041
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers
MH  - Retina
MH  - *Retinal Ganglion Cells
MH  - *Tomography, Optical Coherence/methods
MH  - Adult
PMC - PMC10359552
OTO - NOTNLM
OT  - epidemiology
OT  - optic nerve
OT  - retina
COIS- Competing interests: None declared.
EDAT- 2022/04/07 06:00
MHDA- 2023/07/24 06:42
PMCR- 2023/07/21
CRDT- 2022/04/06 05:23
PHST- 2021/10/18 00:00 [received]
PHST- 2022/03/13 00:00 [accepted]
PHST- 2023/07/24 06:42 [medline]
PHST- 2022/04/07 06:00 [pubmed]
PHST- 2022/04/06 05:23 [entrez]
PHST- 2023/07/21 00:00 [pmc-release]
AID - bjophthalmol-2021-320618 [pii]
AID - 10.1136/bjophthalmol-2021-320618 [doi]
PST - ppublish
SO  - Br J Ophthalmol. 2023 Aug;107(8):1156-1164. doi: 
      10.1136/bjophthalmol-2021-320618. Epub 2022 Apr 5.