PMID- 35383854
OWN - NLM
STAT- MEDLINE
DCOM- 20220422
LR  - 20220716
IS  - 1537-1719 (Electronic)
IS  - 0737-4038 (Print)
IS  - 0737-4038 (Linking)
VI  - 39
IP  - 4
DP  - 2022 Apr 10
TI  - Challenging Ancient DNA Results About Putative HLA Protection or Susceptibility 
      to Yersinia pestis.
LID - 10.1093/molbev/msac073 [doi]
LID - msac073
AB  - In a recent article, Immel et al. (Immel A, Key FM, Szolek A, Barquera R, 
      Robinson MK, Harrison GF, Palmer WH, Spyrou MA, Susat J, Krause-Kyora B, et al. 
      2021. Analysis of genomic DNA from medieval plague victims suggests long-term 
      effect of Yersinia pestis on human immunity genes. Mol Biol Evol. 38:4059-4076) 
      extracted DNA from 36 individuals dead from plague in Ellwangen, Southern 
      Germany, during the 16th century. By comparing their human leukocyte antigen 
      (HLA) genotypes with those of 50 present-day Ellwangen inhabitants, the authors 
      reported a significant decrease of HLA-B*51:01 and HLA-C*06:02 and a significant 
      increase of HLA-DRB1*13:01/13:02 frequencies from ancient to modern populations. 
      After comparing these frequencies with a larger sample of 8,862 modern Germans 
      and performing simulations of natural selection, they concluded that these 
      changes had been driven by natural selection. In an attempt to provide more 
      evidence on such stimulating results, we explored the HLA frequency patterns over 
      all of Europe, we predicted binding affinities of HLA-B/C/DRB1 alleles to 106,515 
      Yersinia pestis-derived peptides, and we performed forward simulations of HLA 
      genetic profiles under neutrality. Our analyses do not sustain the conclusions of 
      HLA protection or susceptibility to plague based on ancient DNA.
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of Society 
      for Molecular Biology and Evolution.
FAU - Di, Da
AU  - Di D
AD  - Laboratory of Anthropology, Genetics and Peopling History, Department of Genetics 
      and Evolution-Anthropology Unit, University of Geneva, Quai Ernest-Ansermet 30, 
      CH-1205 Geneva, Switzerland.
FAU - Simon Thomas, Jeanne
AU  - Simon Thomas J
AD  - Laboratory of Anthropology, Genetics and Peopling History, Department of Genetics 
      and Evolution-Anthropology Unit, University of Geneva, Quai Ernest-Ansermet 30, 
      CH-1205 Geneva, Switzerland.
FAU - Currat, Mathias
AU  - Currat M
AUID- ORCID: 0000-0001-5211-8922
AD  - Laboratory of Anthropology, Genetics and Peopling History, Department of Genetics 
      and Evolution-Anthropology Unit, University of Geneva, Quai Ernest-Ansermet 30, 
      CH-1205 Geneva, Switzerland.
AD  - Institute of Genetics and Genomics in Geneva (IGE3), University of Geneva Medical 
      Centre (CMU), 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland.
FAU - Nunes, Jose Manuel
AU  - Nunes JM
AD  - Laboratory of Anthropology, Genetics and Peopling History, Department of Genetics 
      and Evolution-Anthropology Unit, University of Geneva, Quai Ernest-Ansermet 30, 
      CH-1205 Geneva, Switzerland.
AD  - Institute of Genetics and Genomics in Geneva (IGE3), University of Geneva Medical 
      Centre (CMU), 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland.
FAU - Sanchez-Mazas, Alicia
AU  - Sanchez-Mazas A
AUID- ORCID: 0000-0002-7714-2432
AD  - Laboratory of Anthropology, Genetics and Peopling History, Department of Genetics 
      and Evolution-Anthropology Unit, University of Geneva, Quai Ernest-Ansermet 30, 
      CH-1205 Geneva, Switzerland.
AD  - Institute of Genetics and Genomics in Geneva (IGE3), University of Geneva Medical 
      Centre (CMU), 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mol Biol Evol
JT  - Molecular biology and evolution
JID - 8501455
RN  - 0 (DNA, Ancient)
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - DNA
MH  - DNA, Ancient
MH  - Europe
MH  - *Genetic Predisposition to Disease
MH  - *HLA Antigens/genetics
MH  - Histocompatibility Antigens Class II
MH  - Humans
MH  - *Plague/genetics
MH  - Yersinia pestis
PMC - PMC9021733
OTO - NOTNLM
OT  - Yersinia pestis
OT  - HLA
OT  - ancient DNA
OT  - computer simulations
OT  - pathogen-driven selection
OT  - peptide-binding predictions
EDAT- 2022/04/07 06:00
MHDA- 2022/04/23 06:00
PMCR- 2022/04/06
CRDT- 2022/04/06 09:11
PHST- 2022/04/07 06:00 [pubmed]
PHST- 2022/04/23 06:00 [medline]
PHST- 2022/04/06 09:11 [entrez]
PHST- 2022/04/06 00:00 [pmc-release]
AID - 6564158 [pii]
AID - msac073 [pii]
AID - 10.1093/molbev/msac073 [doi]
PST - ppublish
SO  - Mol Biol Evol. 2022 Apr 10;39(4):msac073. doi: 10.1093/molbev/msac073.