PMID- 35384129
OWN - NLM
STAT- MEDLINE
DCOM- 20220719
LR  - 20231213
IS  - 1099-0461 (Electronic)
IS  - 1095-6670 (Linking)
VI  - 36
IP  - 7
DP  - 2022 Jul
TI  - Selenium attenuates the cadmium-induced placenta glucocorticoid barrier damage by 
      up-regulating the expression of specificity protein 1.
PG  - e23056
LID - 10.1002/jbt.23056 [doi]
AB  - Cadmium (Cd) is an environmental pollutant and pregnant women are especially 
      susceptible to the effects of exposure to Cd. Our previous study found Cd can be 
      accumulated in the placenta and causes fetal growth restriction (FGR) through 
      damage the placental glucocorticoid barrier. Selenium (Se), as an essential 
      micronutrient, can allivate Cd-induced toxicity. In this study, we aim to explore 
      the protective mechanism of Se against Cd-induced the placental glucocorticoid 
      barrier damage and FGR. Pregnant Sprague Dawley (SD) rats were exposed to CdCl(2) 
      (1 mg/kg/day) and Na(2) SeO(3) (0.1-0.2-0.3 mg/kg/day) by gavage from gestational 
      day (GD) 0 to GD 19. The results showed that reduced fetal weight, increased 
      corticosterone concentrations in the maternal and fetal serum, and impaired 
      placental labyrinth layer blood vessel development, appeared in pregnant rats 
      after Cd exposure and improved after treated with Se. In cell experiments, we 
      confirmed that Se reduces Cd-induced apoptosis. Moreover, Se can abolish 
      Cd-induced 11beta-HSD2 and specificity protein 1 (Sp1) decreasing in vivo and vitro. 
      In human JEG-3 cells, the knockdown of Sp1 expression by small interfering RNA 
      can suppressed the protective effect of Se on Cd-induced 11beta-HSD2 decreasing. In 
      general, our results demonstrated that Se is resistant to Cd-induced FGR through 
      upregulating the placenta barrier via activation of the transcription factor Sp1.
CI  - (c) 2022 Wiley Periodicals LLC.
FAU - Wu, Sisi
AU  - Wu S
AD  - Departments of Obstetrics and Gynecology, The Second Affiliated Hospital of 
      Wenzhou Medical University, Wenzhou, Zhejiang, China.
AD  - The Second Clinical Medical College, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
FAU - Chen, Na
AU  - Chen N
AD  - Departments of Obstetrics and Gynecology, The Second Affiliated Hospital of 
      Wenzhou Medical University, Wenzhou, Zhejiang, China.
AD  - The Second Clinical Medical College, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
FAU - Tong, Xia
AU  - Tong X
AD  - Departments of Obstetrics and Gynecology, The Second Affiliated Hospital of 
      Wenzhou Medical University, Wenzhou, Zhejiang, China.
AD  - The Second Clinical Medical College, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
FAU - Xu, Xu
AU  - Xu X
AD  - Departments of Obstetrics and Gynecology, The Second Affiliated Hospital of 
      Wenzhou Medical University, Wenzhou, Zhejiang, China.
AD  - The Second Clinical Medical College, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
FAU - Chen, Qihui
AU  - Chen Q
AD  - Departments of Obstetrics and Gynecology, The Second Affiliated Hospital of 
      Wenzhou Medical University, Wenzhou, Zhejiang, China.
AD  - The Second Clinical Medical College, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
FAU - Wang, Fan
AU  - Wang F
AUID- ORCID: 0000-0002-1583-1419
AD  - Departments of Obstetrics and Gynecology, The Second Affiliated Hospital of 
      Wenzhou Medical University, Wenzhou, Zhejiang, China.
AD  - The Second Clinical Medical College, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
LA  - eng
GR  - Y2020083/Wenzhou Municipal Science and Technology Bureau/
PT  - Journal Article
DEP - 20220405
PL  - United States
TA  - J Biochem Mol Toxicol
JT  - Journal of biochemical and molecular toxicology
JID - 9717231
RN  - 0 (Glucocorticoids)
RN  - 0 (Sp1 Transcription Factor)
RN  - 0 (SP1 protein, human)
RN  - 00BH33GNGH (Cadmium)
RN  - EC 1.1.1.146 (11-beta-Hydroxysteroid Dehydrogenase Type 2)
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - 11-beta-Hydroxysteroid Dehydrogenase Type 2/genetics/metabolism/pharmacology
MH  - Animals
MH  - Cadmium/toxicity
MH  - *Cadmium Poisoning/metabolism
MH  - Cell Line, Tumor
MH  - Female
MH  - Fetal Growth Retardation/chemically induced/metabolism
MH  - Glucocorticoids/pharmacology
MH  - Humans
MH  - Placenta/metabolism
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Selenium/adverse effects
MH  - *Sp1 Transcription Factor/biosynthesis
OTO - NOTNLM
OT  - 11beta-hydroxysteroid dehydrogenase type 2(11beta-HSD2)
OT  - cadmium (Cd)
OT  - rats
OT  - selenium (Se)
OT  - specificity protein 1(Sp1)
EDAT- 2022/04/07 06:00
MHDA- 2022/07/20 06:00
CRDT- 2022/04/06 09:14
PHST- 2022/01/26 00:00 [revised]
PHST- 2021/03/04 00:00 [received]
PHST- 2022/03/02 00:00 [accepted]
PHST- 2022/04/07 06:00 [pubmed]
PHST- 2022/07/20 06:00 [medline]
PHST- 2022/04/06 09:14 [entrez]
AID - 10.1002/jbt.23056 [doi]
PST - ppublish
SO  - J Biochem Mol Toxicol. 2022 Jul;36(7):e23056. doi: 10.1002/jbt.23056. Epub 2022 
      Apr 5.