PMID- 35385632
OWN - NLM
STAT- MEDLINE
DCOM- 20220408
LR  - 20220504
IS  - 2233-6087 (Electronic)
IS  - 2233-6079 (Print)
IS  - 2233-6079 (Linking)
VI  - 46
IP  - 2
DP  - 2022 Mar
TI  - Not Control but Conquest: Strategies for the Remission of Type 2 Diabetes 
      Mellitus.
PG  - 165-180
LID - 10.4093/dmj.2021.0377 [doi]
AB  - A durable normoglycemic state was observed in several studies that treated type 2 
      diabetes mellitus (T2DM) patients through metabolic surgery, intensive 
      therapeutic intervention, or significant lifestyle modification, and it was 
      confirmed that the functional beta-cell mass was also restored to a normal level. 
      Therefore, expert consensus introduced the concept of remission as a common term 
      to express this phenomenon in 2009. Throughout this article, we introduce the 
      recently updated consensus statement on the remission of T2DM in 2021 and share 
      our perspective on the remission of diabetes. There is a need for more research 
      on remission in Korea as well as in Western countries. Remission appears to be 
      prompted by proactive treatment for hyperglycemia and significant weight loss 
      prior to irreversible beta-cell changes. T2DM is not a diagnosis for vulnerable 
      individuals to helplessly accept. We attempt to explain how remission of T2DM can 
      be achieved through a personalized approach. It may be necessary to change the 
      concept of T2DM towards that of an urgent condition that requires rapid 
      intervention rather than a chronic, progressive disease. We must grasp this 
      paradigm shift in our understanding of T2DM for the benefit of our patients as 
      endocrine experts.
FAU - Kim, Jinyoung
AU  - Kim J
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of 
      Korea, Seoul, Korea.
FAU - Kwon, Hyuk-Sang
AU  - Kwon HS
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of 
      Korea, Seoul, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220324
PL  - Korea (South)
TA  - Diabetes Metab J
JT  - Diabetes & metabolism journal
JID - 101556588
SB  - IM
MH  - *Bariatric Surgery
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - Humans
MH  - *Hyperglycemia
MH  - Life Style
MH  - Weight Loss
PMC - PMC8987695
OTO - NOTNLM
OT  - Consensus
OT  - Diabetes mellitus, type 2
OT  - Recovery of function
COIS- CONFLICTS OF INTEREST No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2022/04/07 06:00
MHDA- 2022/04/09 06:00
PMCR- 2022/03/01
CRDT- 2022/04/06 19:28
PHST- 2021/12/29 00:00 [received]
PHST- 2022/03/02 00:00 [accepted]
PHST- 2022/04/06 19:28 [entrez]
PHST- 2022/04/07 06:00 [pubmed]
PHST- 2022/04/09 06:00 [medline]
PHST- 2022/03/01 00:00 [pmc-release]
AID - dmj.2021.0377 [pii]
AID - dmj-2021-0377 [pii]
AID - 10.4093/dmj.2021.0377 [doi]
PST - ppublish
SO  - Diabetes Metab J. 2022 Mar;46(2):165-180. doi: 10.4093/dmj.2021.0377. Epub 2022 
      Mar 24.