PMID- 35386052
OWN - NLM
STAT- MEDLINE
DCOM- 20230508
LR  - 20230603
IS  - 2196-8837 (Electronic)
IS  - 2197-3792 (Print)
IS  - 2196-8837 (Linking)
VI  - 10
IP  - 3
DP  - 2023 Jun
TI  - Racial and Ethnic Disparities in Synchronous and Metachronous Bilateral Breast 
      Cancer.
PG  - 1035-1046
LID - 10.1007/s40615-022-01291-w [doi]
AB  - INTRODUCTION: Significant racial and ethnic disparities exist in breast cancer 
      treatment and survival. However, studies characterizing these disparities among 
      patients developing bilateral breast cancers (BBC) are lacking. The purpose of 
      this study is to understand the association between race and ethnicity, 
      sociodemographic factors, clinical variables, treatment, and mortality in 
      patients with BBC--synchronous bilateral breast cancer (sBBC) or metachronous 
      bilateral breast cancer (mBBC). METHODS: Patients diagnosed with mBBC or sBBC in 
      the Surveillance, Epidemiology, and End Results program between 2010 and 2016 
      were examined. sBBC was defined as contralateral breast cancer <1 year after the 
      initial cancer diagnosis, and mBBC was contralateral cancer >/=1 year. Univariable 
      analysis examined sociodemographic, clinical, and treatment variables. 
      Kaplan-Meier curves and Cox regression models evaluated disease-specific 
      mortality. RESULTS: Of the 11,493 patients that met inclusion criteria, 9575 
      (83.3%) had sBBC, and 1918 (16.7%) had mBBC. There were significant racial and 
      ethnic differences in stage, tumor subtype, surgical management, and chemotherapy 
      within sBBC and mBBC groups. On adjusted multivariate analysis of all BBC 
      patients, Black race (HR 1.42; 95%CI 1.11-1.80; p<0.005; Ref White) was 
      associated with a higher disease-specific mortality. Conversely, patients with 
      mBBC had a 25% relative risk reduction in disease-specific mortality (HR 0.75; 
      95%CI 0.61-0.92; p<0.01) compared to sBBC. Subset analysis suggested Black Race 
      modified the effect of sBBC on mortality (p<0.0001). CONCLUSIONS: Among patients 
      with BBC, there are racial and ethnic disparities in clinical characteristics, 
      treatment, and mortality. Future studies should focus on strategies to reduce 
      these disparities.
CI  - (c) 2022. W. Montague Cobb-NMA Health Institute.
FAU - Hewitt, D Brock
AU  - Hewitt DB
AD  - Division of Surgical Oncology, Department of Surgery, The Ohio State University 
      Wexner Medical Center, N924 Doan Hall 410 West 10th, Columbus, OH, USA.
FAU - Li, Yaming
AU  - Li Y
AD  - Division of Surgical Oncology, Department of Surgery, The Ohio State University 
      Wexner Medical Center, N924 Doan Hall 410 West 10th, Columbus, OH, USA.
FAU - Bhattacharyya, Oindrila
AU  - Bhattacharyya O
AD  - Department of Economics, Indiana University Purdue University, Indianapolis, IN, 
      USA.
AD  - The William Tierney Center for Health Services Research, Regenstrief Institute, 
      Inc., Indianapolis, IN, USA.
FAU - Fisher, James L
AU  - Fisher JL
AD  - Division of Epidemiology, College of Public Health, The Ohio State University, 
      Columbus, OH, USA.
FAU - Stover, Daniel
AU  - Stover D
AD  - Division of Medical Oncology, Ohio State University Comprehensive Cancer Center, 
      Columbus, OH, USA.
FAU - Obeng-Gyasi, Samilia
AU  - Obeng-Gyasi S
AUID- ORCID: 0000-0002-5330-7247
AD  - Division of Surgical Oncology, Department of Surgery, The Ohio State University 
      Wexner Medical Center, N924 Doan Hall 410 West 10th, Columbus, OH, USA. 
      Samilia.Obeng-Gyasi@osumc.edu.
LA  - eng
GR  - K12 CA133250/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20220406
PL  - Switzerland
TA  - J Racial Ethn Health Disparities
JT  - Journal of racial and ethnic health disparities
JID - 101628476
SB  - IM
MH  - Humans
MH  - Female
MH  - *Breast Neoplasms
MH  - Prognosis
MH  - *Neoplasms, Second Primary/epidemiology/pathology
MH  - *Neoplasms, Multiple Primary/therapy/epidemiology/pathology
MH  - Neoplasm Staging
PMC - PMC9535032
MID - NIHMS1800443
OTO - NOTNLM
OT  - Breast cancer
OT  - Disparities
OT  - Ethnicity
OT  - Outcomes
OT  - Race
OT  - Surgery
EDAT- 2022/04/08 06:00
MHDA- 2023/05/08 06:42
PMCR- 2024/06/01
CRDT- 2022/04/07 05:06
PHST- 2021/12/15 00:00 [received]
PHST- 2022/03/18 00:00 [accepted]
PHST- 2022/03/11 00:00 [revised]
PHST- 2024/06/01 00:00 [pmc-release]
PHST- 2023/05/08 06:42 [medline]
PHST- 2022/04/08 06:00 [pubmed]
PHST- 2022/04/07 05:06 [entrez]
AID - 10.1007/s40615-022-01291-w [pii]
AID - 10.1007/s40615-022-01291-w [doi]
PST - ppublish
SO  - J Racial Ethn Health Disparities. 2023 Jun;10(3):1035-1046. doi: 
      10.1007/s40615-022-01291-w. Epub 2022 Apr 6.