PMID- 35386084
OWN - NLM
STAT- MEDLINE
DCOM- 20221028
LR  - 20221028
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 29
IP  - 29
DP  - 2022 Jun
TI  - Modification by genetic polymorphism of lead-induced IQ alteration: a systematic 
      review.
PG  - 43435-43447
LID - 10.1007/s11356-022-19981-7 [doi]
AB  - As well as a lead-related environmental factor, genetic factors could also 
      corroborate important changes in intelligence quotient (IQ) through 
      single-nucleotide polymorphisms. Thus, a systematic review was carried out to 
      evaluate the possible influence of polymorphism on blood Pb levels and IQ points 
      in pediatric patients (0-19 years old). Following the PRISMA guideline, the 
      studies were systematically collected on PubMed, Scopus, and Embase databases. 
      Six genes (transferrin (TF); glutamate ionotropic receptor NMDA type subunit 2A 
      (GRIN2A); glutamate ionotropic receptor NMDA type subunit 2B (GRIN2B); dopamine 
      receptor D2/ankyrin repeat and kinase domain containing 1 ankyrin repeat and 
      kinase domain containing 1 (DRD2/ANKK1); aminolevulinate dehydratase (ALAD); 
      vitamin D receptor (VDR)) were found in six selected articles. In these genes, 11 
      single-nucleotide polymorphisms were searched and six different types of 
      variations (missense variant, intron variant, synonymous variant, stop, stop 
      gained) were observed. Due to the few studies in the literature, there is no 
      conclusive data to point out that there is a direct relationship between 
      polymorphisms, Pb levels, and reduction of IQ points.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Lima, Luiza Siqueira
AU  - Lima LS
AD  - Instituto de Pesquisa Pele Pequeno Principe, Avenida Silva Jardim, 1632, Agua 
      Verde, Curitiba, PR, 80.250-200, Brazil.
AD  - Programa de Pos-Graduacao em Biotecnologia da Saude da Crianca e do Adolescente, 
      Faculdades Pequeno Principe, Curitiba, PR, Brazil.
FAU - Galiciolli, Maria Eduarda Andrade
AU  - Galiciolli MEA
AD  - Instituto de Pesquisa Pele Pequeno Principe, Avenida Silva Jardim, 1632, Agua 
      Verde, Curitiba, PR, 80.250-200, Brazil.
AD  - Programa de Pos-Graduacao em Biotecnologia da Saude da Crianca e do Adolescente, 
      Faculdades Pequeno Principe, Curitiba, PR, Brazil.
FAU - Pereira, Meire Ellen
AU  - Pereira ME
AD  - Instituto de Pesquisa Pele Pequeno Principe, Avenida Silva Jardim, 1632, Agua 
      Verde, Curitiba, PR, 80.250-200, Brazil.
AD  - Programa de Pos-Graduacao em Biotecnologia da Saude da Crianca e do Adolescente, 
      Faculdades Pequeno Principe, Curitiba, PR, Brazil.
FAU - Felisbino, Karoline
AU  - Felisbino K
AD  - Instituto de Pesquisa Pele Pequeno Principe, Avenida Silva Jardim, 1632, Agua 
      Verde, Curitiba, PR, 80.250-200, Brazil.
AD  - Programa de Pos-Graduacao em Biotecnologia da Saude da Crianca e do Adolescente, 
      Faculdades Pequeno Principe, Curitiba, PR, Brazil.
FAU - Machado-Souza, Cleber
AU  - Machado-Souza C
AD  - Instituto de Pesquisa Pele Pequeno Principe, Avenida Silva Jardim, 1632, Agua 
      Verde, Curitiba, PR, 80.250-200, Brazil.
AD  - Programa de Pos-Graduacao em Biotecnologia da Saude da Crianca e do Adolescente, 
      Faculdades Pequeno Principe, Curitiba, PR, Brazil.
FAU - de Oliveira, Claudia Sirlene
AU  - de Oliveira CS
AD  - Instituto de Pesquisa Pele Pequeno Principe, Avenida Silva Jardim, 1632, Agua 
      Verde, Curitiba, PR, 80.250-200, Brazil.
AD  - Programa de Pos-Graduacao em Biotecnologia da Saude da Crianca e do Adolescente, 
      Faculdades Pequeno Principe, Curitiba, PR, Brazil.
FAU - Guiloski, Izonete Cristina
AU  - Guiloski IC
AD  - Instituto de Pesquisa Pele Pequeno Principe, Avenida Silva Jardim, 1632, Agua 
      Verde, Curitiba, PR, 80.250-200, Brazil. 
      izonete.cristina@pelepequenoprincipe.org.br.
AD  - Programa de Pos-Graduacao em Biotecnologia da Saude da Crianca e do Adolescente, 
      Faculdades Pequeno Principe, Curitiba, PR, Brazil. 
      izonete.cristina@pelepequenoprincipe.org.br.
LA  - eng
GR  - 001/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/
PT  - Journal Article
PT  - Systematic Review
DEP - 20220406
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - EC 2.7.11.1 (ANKK1 protein, human)
RN  - 0 (Glutamates)
RN  - 2P299V784P (Lead)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 0 (Nucleotides)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Young Adult
MH  - Genotype
MH  - Glutamates/genetics
MH  - *Lead
MH  - *N-Methylaspartate/genetics
MH  - Nucleotides
MH  - Polymorphism, Single Nucleotide
MH  - Protein Serine-Threonine Kinases
OTO - NOTNLM
OT  - Children
OT  - Genetic
OT  - Intelligence quotient
OT  - Lead
OT  - Neurotoxin
OT  - Polymorphism
EDAT- 2022/04/08 06:00
MHDA- 2022/06/18 06:00
CRDT- 2022/04/07 05:07
PHST- 2021/12/21 00:00 [received]
PHST- 2022/03/25 00:00 [accepted]
PHST- 2022/04/08 06:00 [pubmed]
PHST- 2022/06/18 06:00 [medline]
PHST- 2022/04/07 05:07 [entrez]
AID - 10.1007/s11356-022-19981-7 [pii]
AID - 10.1007/s11356-022-19981-7 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2022 Jun;29(29):43435-43447. doi: 
      10.1007/s11356-022-19981-7. Epub 2022 Apr 6.