PMID- 35386109
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 2049-9442 (Electronic)
IS  - 2049-9434 (Print)
IS  - 2049-9434 (Linking)
VI  - 16
IP  - 5
DP  - 2022 May
TI  - Genetic association between miR-27a and miR-449b polymorphisms and susceptibility 
      to diabetes mellitus.
PG  - 37
LID - 10.3892/br.2022.1520 [doi]
LID - 37
AB  - Various mutations in microRNAs (miRs) are associated with the pathogenesis of 
      several diseases including cancers and vascular diseases. The present study aimed 
      to investigate the potential association between miR-27a A>G (rs895819) and 
      miR-449b A>G (rs10061133) polymorphisms with the prevalence of type 2 diabetes 
      mellitus (T2DM), and its associated risk factors in the Korean population. 
      Genotype analysis was performed using PCR-restriction fragment length 
      polymorphism analysis to assess the frequency of miR-27a and miR-449b gene 
      polymorphisms in patients diagnosed with T2DM (n=238) and healthy controls 
      (n=247). The miR-27a GG genotype, recessive model, and G allele were 
      significantly associated with a decreased risk of T2DM [adjusted odds ratio 
      (AOR)=0.378, 95% confidence interval (CI): 0.208-0.686, P=0.001; AOR=0.425, 95% 
      CI: 0.246-0.734, P=0.002; AOR=0.640, 95% CI: 0.493-0.831, P=0.001, respectively). 
      Although the miR-449b polymorphism was not associated with the prevalence of 
      T2DM, the genotype and allele combination analyses for miR-27a and miR-449b 
      polymorphisms showed associations with T2DM prevalence. Furthermore, 
      stratification analysis revealed that the miR-27a polymorphism was associated 
      with DM risk factors including body mass index (<28.12 kg/m(2), P=0.031), waist 
      circumference (<93.03 cm, P=0.036), systolic blood pressure (<132.67 mmHg, 
      P=0.017), fasting blood glucose levels (<106.26 mg/dl, P=0.015), glycosylated 
      hemoglobin, type A1C (</=125.5 mg/dl, P=0.001), total cholesterol (</=240 mg/dl, 
      P=0.010) and low-density lipoprotein levels (</=130 mg/dl, P=0.028). The present 
      study revealed an association between miR-27a A>G and miR-449b A>G polymorphisms 
      and the risk of DM in Koreans, which suggests that these gene polymorphisms could 
      represent potential markers for predicting T2DM risk.
CI  - Copyright (c) 2020, Spandidos Publications.
FAU - Choi, Youngmi
AU  - Choi Y
AD  - Department of Science Education, Teachers College, Jeju National University, Jeju 
      63294, Republic of Korea.
FAU - Hong, Seung-Ho
AU  - Hong SH
AD  - Department of Science Education, Teachers College, Jeju National University, Jeju 
      63294, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20220302
PL  - England
TA  - Biomed Rep
JT  - Biomedical reports
JID - 101613227
PMC - PMC8972843
OTO - NOTNLM
OT  - association
OT  - miR-27a rs895819
OT  - miR-449b rs10061133
OT  - polymerase chain reaction-restriction fragment length polymorphism
OT  - type 2 diabetes mellitus
COIS- The authors declare that they have no competing interests.
EDAT- 2022/04/08 06:00
MHDA- 2022/04/08 06:01
PMCR- 2022/03/02
CRDT- 2022/04/07 05:08
PHST- 2021/12/19 00:00 [received]
PHST- 2022/02/10 00:00 [accepted]
PHST- 2022/04/07 05:08 [entrez]
PHST- 2022/04/08 06:00 [pubmed]
PHST- 2022/04/08 06:01 [medline]
PHST- 2022/03/02 00:00 [pmc-release]
AID - BR-16-5-01520 [pii]
AID - 10.3892/br.2022.1520 [doi]
PST - ppublish
SO  - Biomed Rep. 2022 May;16(5):37. doi: 10.3892/br.2022.1520. Epub 2022 Mar 2.