PMID- 35386621
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Print)
IS  - 1792-0981 (Linking)
VI  - 23
IP  - 5
DP  - 2022 May
TI  - Preliminary study on the differentiation of vulnerable carotid plaques via 
      analysis of calcium content and spectral curve slope by using gemstone spectral 
      imaging.
PG  - 325
LID - 10.3892/etm.2022.11254 [doi]
LID - 325
AB  - Growing evidence indicates that vulnerable carotid plaque rupture is an important 
      cause of stroke. However, the role of novel gemstone spectral imaging (GSI) in 
      the assessment of vulnerable carotid plaques has remained to be sufficiently 
      explored. Therefore, the aim of the present study was to provide a comprehensive 
      evaluation of carotid atherosclerotic plaques using both GSI imaging biomarkers 
      and serological biomarkers, and further explore their possible roles in the 
      atherogenic process. The present study analyzed GSI data, including calcium 
      content of carotid atherosclerotic plaques and spectral curve slope, as well as 
      serum high-sensitivity C-reactive protein (Hs-CRP) and monocyte chemotactic 
      protein-1 (MCP-1) levels in patients with a carotid atherosclerotic plaque using 
      GSI-computed tomographic angiography and immunoturbidimetry. Patients with 
      unstable plaque exhibited a significantly lower calcium content and higher 
      spectral curve slope than those of the stable plaque group. In addition, patients 
      with unstable plaque exhibited an increase in Hs-CRP and MCP-1 levels compared 
      with those of the stable plaque and normal control groups. The alteration in GSI 
      calcium content and spectral curve slope reflects a close link between 
      calcification and plaque instability, while aberrant Hs-CRP and MCP-1 expression 
      are involved in the formation or development of vulnerable plaques. Taken 
      together, the present results strongly support the feasibility of using these 
      serological and newly identified imaging parameters as multiple potential 
      biomarkers relevant to plaque vulnerability or stroke progression.
CI  - Copyright: (c) Fan et al.
FAU - Fan, Ze-Xin
AU  - Fan ZX
AD  - Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, 
      Beijing 100029, P.R. China.
FAU - Yuan, Shao-Jie
AU  - Yuan SJ
AD  - Department of Neurology, Second Hospital of Shanxi Medical University, Taiyuan, 
      Shanxi 030001, P.R. China.
FAU - Li, Xiao-Qing
AU  - Li XQ
AD  - Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, 
      Beijing 100029, P.R. China.
FAU - Yang, Ting-Ting
AU  - Yang TT
AD  - Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, 
      Beijing 100029, P.R. China.
FAU - Niu, Tian-Tong
AU  - Niu TT
AD  - Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, 
      Beijing 100029, P.R. China.
FAU - Ma, Lin
AU  - Ma L
AD  - Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, 
      Beijing 100029, P.R. China.
FAU - Sun, Kai
AU  - Sun K
AD  - Department of Imaging, Second Hospital of Shanxi Medical University, Taiyuan, 
      Shanxi 030001, P.R. China.
FAU - Wang, Li
AU  - Wang L
AD  - Department of Neurology, Second Hospital of Shanxi Medical University, Taiyuan, 
      Shanxi 030001, P.R. China.
FAU - Liu, Guang-Zhi
AU  - Liu GZ
AD  - Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, 
      Beijing 100029, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20220314
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC8972840
OTO - NOTNLM
OT  - gemstone spectral imaging
OT  - high-sensitivity C-reactive protein
OT  - monocyte chemotactic protein-1
OT  - plaque vulnerability
COIS- The authors declare that they have no competing interests.
EDAT- 2022/04/08 06:00
MHDA- 2022/04/08 06:01
PMCR- 2022/03/14
CRDT- 2022/04/07 05:15
PHST- 2021/11/02 00:00 [received]
PHST- 2022/02/23 00:00 [accepted]
PHST- 2022/04/07 05:15 [entrez]
PHST- 2022/04/08 06:00 [pubmed]
PHST- 2022/04/08 06:01 [medline]
PHST- 2022/03/14 00:00 [pmc-release]
AID - ETM-23-5-11254 [pii]
AID - 10.3892/etm.2022.11254 [doi]
PST - ppublish
SO  - Exp Ther Med. 2022 May;23(5):325. doi: 10.3892/etm.2022.11254. Epub 2022 Mar 14.