PMID- 35387401
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230102
IS  - 2156-4647 (Electronic)
IS  - 2156-4639 (Print)
VI  - 8
IP  - 1
DP  - 2022
TI  - A multi-institutional analysis of outcomes following stereotactic body radiation 
      therapy for management of metastases from squamous cell carcinomas of the head 
      and neck.
PG  - 11-19
AB  - BACKGROUND: There is limited data on clinical outcomes following SBRT for 
      patients with metastatic head and neck squamous cell carcinoma (mHNC). METHOD: An 
      international SBRT registry was utilized to identify patients. LC and OS were 
      evaluated with the Kaplan-Meier method and a Cox-proportional hazards model for 
      multivariate analysis (MVA) to assess potential prognostic factors. RESULTS: We 
      identified 81 patients with 98 lesions treated with SBRT. Areas treated included 
      the lung (53.0%), non-regional lymph nodes (16.0%), and spine (12.3%). OS rates 
      at 1 year and 2 years were 66.4% and 43.1%, respectively. Utilizing KPS, spinal 
      disease, and GTV, 1-year OS estimates were 90.9%, 70.4%, 54.5%, and 25% for 
      patients with 0-3 of these factors, respectively (p = 0.002). One-year and 2-year 
      LC rates were both 93.3%. Roughly 17% of patients reported toxicities (none Grade 
      3+). CONCLUSIONS: SBRT resulted in promising LC for mHNC patients. Spinal 
      disease, GTV, and KPS should be considered in selecting patients with mHNC that 
      may benefit from SBRT.
CI  - (c) 2022 Old City Publishing, Inc.
FAU - Singh, Raj
AU  - Singh R
AD  - Virginia Commonwealth University Health System, Department of Radiation Oncology, 
      Richmond, VA, USA.
FAU - Jenkins, Jan
AU  - Jenkins J
AD  - The Radiosurgery Society, Sunnyvale, CA, USA.
FAU - Davis, Joanne
AU  - Davis J
AD  - The Radiosurgery Society, Sunnyvale, CA, USA.
FAU - Song, Shiyu
AU  - Song S
AD  - Virginia Commonwealth University Health System, Department of Radiation Oncology, 
      Richmond, VA, USA.
FAU - Sharma, Sanjeev
AU  - Sharma S
AD  - St. Mary's Medical Center, Department of Radiation Oncology, Huntington, WV, USA.
FAU - Vargo, John Austin
AU  - Vargo JA
AD  - University of Pittsburgh Hillman Cancer Center, Department of Radiation Oncology, 
      Pittsburgh, PA, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Radiosurg SBRT
JT  - Journal of radiosurgery and SBRT
JID - 101565296
PMC - PMC8930056
OTO - NOTNLM
OT  - Stereotactic body radiation therapy
OT  - ablation
OT  - local control
OT  - oligometastasis
OT  - overall survival
OT  - registry
COIS- Authors' disclosure of potential conflicts of interest The authors have nothing 
      to disclose.
EDAT- 2022/04/08 06:00
MHDA- 2022/04/08 06:01
PMCR- 2023/01/01
CRDT- 2022/04/07 05:25
PHST- 2021/05/25 00:00 [received]
PHST- 2021/08/05 00:00 [accepted]
PHST- 2022/04/07 05:25 [entrez]
PHST- 2022/04/08 06:00 [pubmed]
PHST- 2022/04/08 06:01 [medline]
PHST- 2023/01/01 00:00 [pmc-release]
AID - RSBRT-8-19 [pii]
PST - ppublish
SO  - J Radiosurg SBRT. 2022;8(1):11-19.