PMID- 35387442
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 9
DP  - 2022
TI  - Usefulness of Platelet Distribution Width and Fibrinogen in Predicting In-stent 
      Restenosis With Stable Angina and Type 2 Patients With Diabetes Mellitus.
PG  - 710804
LID - 10.3389/fcvm.2022.710804 [doi]
LID - 710804
AB  - AIM: The purpose of this study was to investigate the predicting value of 
      platelet distribution width (PDW) and fibrinogen for in-stent restenosis (ISR) in 
      patients with stable angina pectoris and type 2 diabetes mellitus (T2DM) after 
      drug-eluting stent (DES) implantation. METHODS: We enrolled 161 patients who were 
      readmitted with recurrent chest pain and successfully reviewed for coronary 
      angiography and were divided into the ISR and non-ISR groups. We compared the 
      levels of PDW and fibrinogen between the two groups. Logistic regression was used 
      for analyzing independent predictors of ISR. The receiver operating 
      characteristic (ROC) curve analysis was used to determine the optimum cutoff 
      points of PDW and fibrinogen to predict ISR. The Kaplan-Meier survival curves for 
      target lesion failure (TLF) by levels of PDW and fibrinogen. RESULTS: The 
      multivariate logistic regression analysis showed that PDW and fibrinogen were 
      independent predictors of ISR [odds ratio (OR) = 1.209, 95% CI: 1.024-1.427, p = 
      0.025; OR = 1.006, 95% CI: 1.002-1.011, p = 0.010, respectively]. The ROC 
      analyses showed that PDW >/= 13.15% and fibrinogen >/= 333.5 mg/dl were predictive of 
      ISR in patients with stable angina pectoris and T2DM after DES implantation. 
      However, the Kaplan-Meier estimate for TLF showed no statistical significance. 
      CONCLUSION: Higher levels of PDW and fibrinogen were associated with the 
      incidence of ISR in patients with stable angina with T2DM after DES implantation, 
      but were not independent predictors of TLF.
CI  - Copyright (c) 2022 Chai, Yang, Wang, Lu, Dai and Zhou.
FAU - Chai, Dayang
AU  - Chai D
AD  - Department of Cardiology, The First People's Hospital of Taicang, The Affiliated 
      Taicang Hospital of Soochow University, Taicang, China.
FAU - Yang, Xi
AU  - Yang X
AD  - Department of Endocrinology, The First People's Hospital of Taicang, The 
      Affiliated Taicang Hospital of Soochow University, Taicang, China.
FAU - Wang, Aichao
AU  - Wang A
AD  - Department of Cardiology, The First People's Hospital of Taicang, The Affiliated 
      Taicang Hospital of Soochow University, Taicang, China.
FAU - Lu, Shu
AU  - Lu S
AD  - Department of Cardiology, The First People's Hospital of Taicang, The Affiliated 
      Taicang Hospital of Soochow University, Taicang, China.
FAU - Dai, Yuxiang
AU  - Dai Y
AD  - Department of Cardiology, Zhongshan Hospital Affiliated of Fudan University, 
      Shanghai, China.
FAU - Zhou, Jing
AU  - Zhou J
AD  - Department of Cardiology, The First People's Hospital of Taicang, The Affiliated 
      Taicang Hospital of Soochow University, Taicang, China.
LA  - eng
PT  - Journal Article
DEP - 20220321
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC8977890
OTO - NOTNLM
OT  - drug-eluting stent implantation (DES-PCI)
OT  - fibrinogen
OT  - in-stent restenosis
OT  - inflammation
OT  - platelet distribution width (PDW)
OT  - stable angina pectoris (SAP)
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/04/08 06:00
MHDA- 2022/04/08 06:01
PMCR- 2022/01/01
CRDT- 2022/04/07 05:25
PHST- 2021/08/11 00:00 [received]
PHST- 2022/01/25 00:00 [accepted]
PHST- 2022/04/07 05:25 [entrez]
PHST- 2022/04/08 06:00 [pubmed]
PHST- 2022/04/08 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2022.710804 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2022 Mar 21;9:710804. doi: 10.3389/fcvm.2022.710804. 
      eCollection 2022.