PMID- 35387473
OWN - NLM
STAT- MEDLINE
DCOM- 20220616
LR  - 20220722
IS  - 1557-9077 (Electronic)
IS  - 1050-7256 (Linking)
VI  - 32
IP  - 6
DP  - 2022 Jun
TI  - Association of Human Leukocyte Antigen Genotypes with Severe Acute Respiratory 
      Syndrome Coronavirus 2 Vaccine-Induced Subacute Thyroiditis.
PG  - 640-647
LID - 10.1089/thy.2022.0010 [doi]
AB  - Background: Despite mass vaccination, severe acute respiratory syndrome 
      coronavirus 2 (SARS-CoV-2) vaccine-induced subacute thyroiditis (SAT) is rarely 
      seen as a complication. The reason why some individuals are susceptible to 
      developing vaccine-induced SAT is not known. SAT develops in genetically 
      predisposed individuals who carry specific human leukocyte antigen (HLA) 
      haplotypes. It is unknown whether specific HLA alleles are associated with 
      SARS-CoV-2 vaccine-induced SAT. Objective: This study compared the HLA profiles 
      of patients with SARS-CoV-2 vaccine-induced SAT to controls, to assess whether 
      there is an association between specific HLA genotypes and development of SAT. 
      The relationship between HLA genotypes and the clinical course of SARS-CoV-2 
      vaccine-induced SAT was also evaluated. Methods: A case-control study was 
      conducted in a Turkish tertiary care center. Fourteen patients with SARS-CoV-2 
      vaccine-induced SAT and 100 healthy controls were included. HLA-A, HLA-B, HLA-C, 
      HLA-DQB1, and HLA-DRB1 frequencies were analyzed by next-generation sequencing. 
      Results: The frequencies of HLA-B*35 and HLA-C*04 alleles were significantly 
      higher in SARS-CoV-2 vaccine-induced SAT cohort when compared with controls 
      (HLA-B*35: 13 [93%] vs. 40 [40%], p < 0.001; HLA-C*04: 13 [93%] vs. 43 [43%], 
      p < 0.001, respectively). More severe thyrotoxicosis was seen in patients having 
      HLA-B*35 and HLA-C*04 homozygous alleles (free thyroxine: 4.47 ng/dL [3.77-5.18] 
      vs. 1.41 ng/dL [1.22-2.63], p = 0.048). Inflammation tended to be more severe in 
      homozygous patients (C-reactive protein: 28.2 mg/dL [13.6-42.9] vs. 4.8 
      [1.2-10.5], p = 0.07). Conclusions: The frequencies of HLA-B*35 and HLA-C*04 
      alleles were higher in SARS-CoV-2 vaccine-induced SAT compared with controls. 
      Homozygosity for HLA-B*35 and HLA-C*04 was associated with thyrotoxicosis and a 
      greater inflammatory reaction. Our findings should be confirmed in studies of 
      other populations.
FAU - Sendur, Suleyman Nahit
AU  - Sendur SN
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Hacettepe University School of Medicine, Ankara, Turkey.
FAU - Ozmen, Fusun
AU  - Ozmen F
AD  - Department of Basic Oncology, Hacettepe University Cancer Institute, Ankara, 
      Turkey.
FAU - Oguz, Seda Hanife
AU  - Oguz SH
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Hacettepe University School of Medicine, Ankara, Turkey.
FAU - Iremli, Burcin Gonul
AU  - Iremli BG
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Hacettepe University School of Medicine, Ankara, Turkey.
FAU - Malkan, Umit Yavuz
AU  - Malkan UY
AUID- ORCID: 0000-0001-5444-4895
AD  - Division of Hematology, Hacettepe University School of Medicine, Ankara, Turkey.
FAU - Gurlek, Alper
AU  - Gurlek A
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Hacettepe University School of Medicine, Ankara, Turkey.
FAU - Erbas, Tomris
AU  - Erbas T
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Hacettepe University School of Medicine, Ankara, Turkey.
FAU - Unluturk, Ugur
AU  - Unluturk U
AUID- ORCID: 0000-0002-5054-1396
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Hacettepe University School of Medicine, Ankara, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20220509
PL  - United States
TA  - Thyroid
JT  - Thyroid : official journal of the American Thyroid Association
JID - 9104317
RN  - 0 (COVID-19 Vaccines)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
SB  - IM
MH  - *COVID-19/prevention & control
MH  - COVID-19 Vaccines/adverse effects
MH  - Case-Control Studies
MH  - Genotype
MH  - HLA-B Antigens/genetics
MH  - HLA-C Antigens/genetics
MH  - Humans
MH  - SARS-CoV-2
MH  - *Thyroiditis, Subacute/genetics
MH  - *Thyrotoxicosis
OTO - NOTNLM
OT  - ASIA syndrome
OT  - COVID-19
OT  - HLA
OT  - SARS-CoV-2
OT  - subacute thyroiditis
OT  - vaccine
EDAT- 2022/04/08 06:00
MHDA- 2022/06/18 06:00
CRDT- 2022/04/07 05:26
PHST- 2022/04/08 06:00 [pubmed]
PHST- 2022/06/18 06:00 [medline]
PHST- 2022/04/07 05:26 [entrez]
AID - 10.1089/thy.2022.0010 [doi]
PST - ppublish
SO  - Thyroid. 2022 Jun;32(6):640-647. doi: 10.1089/thy.2022.0010. Epub 2022 May 9.