PMID- 35392133
OWN - NLM
STAT- MEDLINE
DCOM- 20220411
LR  - 20220727
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 13
DP  - 2022
TI  - Overview and New Insights Into the Diversity, Evolution, Role, and Regulation of 
      Kisspeptins and Their Receptors in Teleost Fish.
PG  - 862614
LID - 10.3389/fendo.2022.862614 [doi]
LID - 862614
AB  - In the last two decades, kisspeptin (Kiss) has been identified as an important 
      player in the regulation of reproduction and other physiological functions in 
      vertebrates, including several fish species. To date, two ligands (Kiss1, Kiss2) 
      and three kisspeptin receptors (Kissr1, Kissr2, Kissr3) have been identified in 
      teleosts, likely due to whole-genome duplication and loss of genes that occurred 
      early in teleost evolution. Recent results in zebrafish and medaka mutants have 
      challenged the notion that the kisspeptin system is essential for reproduction in 
      fish, in marked contrast to the situation in mammals. In this context, this 
      review focuses on the role of kisspeptins at three levels of the reproductive, 
      brain-pituitary-gonadal (BPG) axis in fish. In addition, this review compiled 
      information on factors controlling the Kiss/Kissr system, such as photoperiod, 
      temperature, nutritional status, sex steroids, neuropeptides, and others. In this 
      article, we summarize the available information on the molecular diversity and 
      evolution, tissue expression and neuroanatomical distribution, functional 
      significance, signaling pathways, and gene regulation of Kiss and Kissr in 
      teleost fishes. Of particular note are recent advances in understanding flatfish 
      kisspeptin systems, which require further study to reveal their structural and 
      functional diversity.
CI  - Copyright (c) 2022 Wang, Mechaly and Somoza.
FAU - Wang, Bin
AU  - Wang B
AD  - Key Laboratory of Sustainable Development of Marine Fisheries, Ministry of 
      Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Chinese 
      Academy of Fishery Sciences, Qingdao, China.
AD  - Laboratory for Marine Fisheries and Food Production Processes, Pilot National 
      Laboratory for Marine Science and Technology (Qingdao), Qingdao, China.
FAU - Mechaly, Alejandro S
AU  - Mechaly AS
AD  - Instituto de Investigaciones en Biodiversidad y Biotecnologia (INBIOTEC-CONICET), 
      Mar del Plata, Argentina.
AD  - Fundacion para Investigaciones Biologicas Aplicadas (FIBA), Mar del Plata, 
      Argentina.
FAU - Somoza, Gustavo M
AU  - Somoza GM
AD  - Instituto Tecnologico de Chascomus (CONICET-UNSAM), Chascomus, Argentina.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220322
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (Kisspeptins)
RN  - 0 (Ligands)
RN  - 0 (Receptors, G-Protein-Coupled)
SB  - IM
MH  - Animals
MH  - Brain/metabolism
MH  - *Kisspeptins/genetics/metabolism
MH  - Ligands
MH  - Oryzias/genetics
MH  - *Receptors, G-Protein-Coupled/genetics/metabolism
MH  - Reproduction/genetics
MH  - *Zebrafish
PMC - PMC8982144
OTO - NOTNLM
OT  - fish
OT  - gene regulation
OT  - kisspeptin
OT  - kisspeptin receptor
OT  - reproduction
OT  - signaling pathway
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/04/09 06:00
MHDA- 2022/04/12 06:00
PMCR- 2022/01/01
CRDT- 2022/04/08 05:16
PHST- 2022/01/26 00:00 [received]
PHST- 2022/02/21 00:00 [accepted]
PHST- 2022/04/08 05:16 [entrez]
PHST- 2022/04/09 06:00 [pubmed]
PHST- 2022/04/12 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2022.862614 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2022 Mar 22;13:862614. doi: 
      10.3389/fendo.2022.862614. eCollection 2022.