PMID- 35393327
OWN - NLM
STAT- MEDLINE
DCOM- 20220411
LR  - 20220526
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 12
IP  - 4
DP  - 2022 Apr 7
TI  - Cohort profile: 'Biomarkers of Personalised Medicine' (BioPersMed): a 
      single-centre prospective observational cohort study in Graz/Austria to evaluate 
      novel biomarkers in cardiovascular and metabolic diseases.
PG  - e058890
LID - 10.1136/bmjopen-2021-058890 [doi]
LID - e058890
AB  - PURPOSE: Accumulating evidence points towards a close relationship between 
      cardiovascular, endocrine and metabolic diseases. The BioPersMed Study 
      (Biomarkers of Personalised Medicine) is a single-centre prospective 
      observational cohort study with repetitive examination of participants in 2-year 
      intervals. The aim is to evaluate the predictive impact of various traditional 
      and novel biomarkers of cardiovascular, endocrine and metabolic pathways in 
      asymptomatic individuals at risk for cardiovascular and/or metabolic disease. 
      PARTICIPANTS: Between 2010 and 2016, we recruited 1022 regional individuals into 
      the study. Subjects aged 45 years or older presenting with at least one 
      traditional cardiovascular risk factor or manifest type 2 diabetes mellitus 
      (T2DM) were enrolled. The mean age of the participants was 57+/-8 years, 55% were 
      female, 18% had T2DM, 33% suffered from arterial hypertension, 15% were smokers, 
      42% had hyperlipidaemia, and only 26% were at low cardiovascular risk according 
      to the Framingham 'Systematic COronary Risk Evaluation'. FINDINGS TO DATE: Study 
      procedures during screening and follow-up visits included a physical examination 
      and comprehensive cardiovascular, endocrine, metabolic, ocular and laboratory 
      workup with biobanking of blood and urine samples. The variety of assessed 
      biomarkers allows a full phenotyping of individuals at cardiovascular and 
      metabolic risk. Preliminary data from the cohort and relevant biomarker analyses 
      were already used as control population for genomic studies in local and 
      international research cooperation. FUTURE PLANS: Participants will undergo 
      comprehensive cardiovascular, endocrine and metabolic examinations for the next 
      decades and clinical outcomes will be adjudicated prospectively.
CI  - (c) Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No 
      commercial re-use. See rights and permissions. Published by BMJ.
FAU - Haudum, Christoph Walter
AU  - Haudum CW
AUID- ORCID: 0000-0002-3872-5643
AD  - Center for Biomarker Research in Medicine, Graz, Austria.
AD  - Department of Internal Medicine, Medical University, Graz, Austria.
FAU - Kolesnik, Ewald
AU  - Kolesnik E
AD  - Department of Internal Medicine, Medical University and University Heart Center, 
      Graz, Austria.
FAU - Colantonio, Caterina
AU  - Colantonio C
AD  - Department of Internal Medicine, Medical University and University Heart Center, 
      Graz, Austria.
FAU - Mursic, Ines
AU  - Mursic I
AD  - Department of Internal Medicine, Medical University, Graz, Austria.
FAU - Url-Michitsch, Marion
AU  - Url-Michitsch M
AD  - Department of Internal Medicine, Medical University and University Heart Center, 
      Graz, Austria.
FAU - Tomaschitz, Andreas
AU  - Tomaschitz A
AD  - Department of Internal Medicine, Medical University and University Heart Center, 
      Graz, Austria.
FAU - Glantschnig, Theresa
AU  - Glantschnig T
AD  - Department of Internal Medicine, Medical University and University Heart Center, 
      Graz, Austria.
FAU - Hutz, Barbara
AU  - Hutz B
AD  - Department of Internal Medicine, Medical University, Graz, Austria.
FAU - Lind, Alice
AU  - Lind A
AD  - Department of Internal Medicine, Medical University, Graz, Austria.
FAU - Schweighofer, Natascha
AU  - Schweighofer N
AD  - Department of Internal Medicine, Medical University, Graz, Austria.
FAU - Reiter, Clemens
AU  - Reiter C
AD  - Department of Internal Medicine, Medical University and University Heart Center, 
      Graz, Austria.
AD  - Department of Radiology, Medizinische Universitat, Graz, Austria.
FAU - Ablasser, Klemens
AU  - Ablasser K
AD  - Department of Internal Medicine, Medical University and University Heart Center, 
      Graz, Austria.
FAU - Wallner, Markus
AU  - Wallner M
AD  - Department of Internal Medicine, Medical University and University Heart Center, 
      Graz, Austria.
AD  - Cardiovascular Research Center, Lewis Katz School of Medicine at Temple 
      University, Philadelphia, Pennsylvania, USA.
FAU - Tripolt, Norbert Joachim
AU  - Tripolt NJ
AD  - Department of Internal Medicine, Medizinische Universitat, Graz, Austria.
FAU - Pieske-Kraigher, Elisabeth
AU  - Pieske-Kraigher E
AD  - Department of Internal Medicine and Cardiology, Charite University Medicine, 
      Berlin, Germany.
FAU - Madl, Tobias
AU  - Madl T
AD  - Gottfried Schatz Research Center, Medical University, Graz, Austria.
AD  - BioTechMed, Graz, Austria.
FAU - Springer, Alexander
AU  - Springer A
AD  - Gottfried Schatz Research Center, Medical University, Graz, Austria.
AD  - BioTechMed, Graz, Austria.
FAU - Seidel, Gerald
AU  - Seidel G
AD  - Department of Ophthalmology, Medical University, Graz, Austria.
FAU - Wedrich, Andreas
AU  - Wedrich A
AD  - Department of Ophthalmology, Medizinische Universitat, Graz, Austria.
FAU - Zirlik, Andreas
AU  - Zirlik A
AD  - Department of Internal Medicine, Medical University and University Heart Center, 
      Graz, Austria.
FAU - Krahn, Thomas
AU  - Krahn T
AD  - Department of Internal Medicine, Medical University, Graz, Austria.
AD  - Department of Pharmacology and Personalised Medicine, Maastricht University, 
      Maastricht, The Netherlands.
FAU - Stauber, Rudolf
AU  - Stauber R
AD  - Department of Internal Medicine, Medizinische Universitat, Graz, Austria.
FAU - Pieske, Burkert
AU  - Pieske B
AD  - Department of Internal Medicine and Cardiology, Charite University Medicine, 
      Berlin, Germany.
FAU - Pieber, Thomas R
AU  - Pieber TR
AD  - Center for Biomarker Research in Medicine, Graz, Austria.
AD  - Department of Internal Medicine, Medical University, Graz, Austria.
FAU - Verheyen, Nicolas
AU  - Verheyen N
AD  - Department of Internal Medicine, Medical University and University Heart Center, 
      Graz, Austria.
FAU - Obermayer-Pietsch, Barbara
AU  - Obermayer-Pietsch B
AD  - Department of Internal Medicine, Medical University, Graz, Austria 
      barbara.obermayer@medunigraz.at.
FAU - Schmidt, Albrecht
AU  - Schmidt A
AD  - Department of Internal Medicine, Medical University and University Heart Center, 
      Graz, Austria.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20220407
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
RN  - 0 (Biomarkers)
SB  - IM
MH  - Aged
MH  - Austria
MH  - Biological Specimen Banks
MH  - Biomarkers
MH  - *Cardiovascular Diseases/diagnosis/epidemiology
MH  - Cohort Studies
MH  - *Diabetes Mellitus, Type 2/diagnosis/epidemiology
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Precision Medicine
MH  - Prospective Studies
MH  - Risk Factors
PMC - PMC8991072
OTO - NOTNLM
OT  - Cardiac Epidemiology
OT  - General diabetes
OT  - General endocrinology
COIS- Competing interests: None declared.
EDAT- 2022/04/09 06:00
MHDA- 2022/04/12 06:00
PMCR- 2022/04/06
CRDT- 2022/04/08 05:30
PHST- 2022/04/08 05:30 [entrez]
PHST- 2022/04/09 06:00 [pubmed]
PHST- 2022/04/12 06:00 [medline]
PHST- 2022/04/06 00:00 [pmc-release]
AID - bmjopen-2021-058890 [pii]
AID - 10.1136/bmjopen-2021-058890 [doi]
PST - epublish
SO  - BMJ Open. 2022 Apr 7;12(4):e058890. doi: 10.1136/bmjopen-2021-058890.