PMID- 35393387
OWN - NLM
STAT- MEDLINE
DCOM- 20220411
LR  - 20220506
IS  - 1941-5923 (Electronic)
IS  - 1941-5923 (Linking)
VI  - 23
DP  - 2022 Apr 8
TI  - Pancreatic Carcinoid Tumor in a Pediatric Patient.
PG  - e936029
LID - 10.12659/AJCR.936029 [doi]
AB  - BACKGROUND Carcinoid tumors are well-differentiated tumors that develop from 
      neuroendocrine cells. They are rare tumors and occur most commonly in the 
      gastrointestinal tract, followed by the pulmonary system. They usually present 
      with abdominal pain or cough or persistent pneumonia. They are usually diagnosed 
      with computed tomography (CT) or magnetic resonance imaging (MRI) of the chest or 
      abdomen. The cornerstone of treatment is surgical resection. There are rare 
      reported cases of carcinoid tumor presenting in the pancreas as gastrinoma or 
      insulinoma and are associated with multiple endocrine neoplasia type 1 (MEN1). 
      CASE REPORT We report a case of an otherwise healthy 9-year-old girl who 
      presented with manifestations of Cushing syndrome (easy fatigability, weakness, 
      back pain, easy bruising, hirsutism, acne, skin discoloration [pigmentation], and 
      blurred vision). She was diagnosed with incidental carcinoid tumor in the 
      pancreas based on hypertension and typical stigmata. She underwent distal 
      pancreatectomy and splenectomy. The histopathology showed a well-differentiated 
      neuroendocrine tumor with G2. The diagnosis of concurrent Cushing syndrome and 
      carcinoid syndrome can be challenging, as it is rare. It is important to screen 
      for MEN syndrome when Cushing syndrome occurs in a child, as there is a high rate 
      of transition to malignancy. They are usually diagnosed with ACTH, cortisol, and 
      imaging. CONCLUSIONS Incidental hypertension in children is not common and 
      mandates further investigation and clinical work-up to look for endocrinopathies 
      such as Cushing syndrome and carcinoid syndrome. As the literature on such cases 
      is scant, further reporting of cases is needed.
FAU - Musalli, Dania Ibrahim
AU  - Musalli DI
AD  - Department of Pediatrics, East Jeddah General Hospital, Jeddah, Saudi Arabia.
FAU - Binafif, Yasser Ali
AU  - Binafif YA
AD  - Department of Pediatrics, East Jeddah General Hospital, Jeddah, Saudi Arabia.
FAU - Mirdad, Abeer M
AU  - Mirdad AM
AD  - Department of Pediatrics, East Jeddah General Hospital, Jeddah, Saudi Arabia.
FAU - Moshref, Leena H
AU  - Moshref LH
AD  - Department of Surgery, Dr. Soliman Fakeeh Hospital, Jeddah, Saudi Arabia.
FAU - Moshref, Rana H
AU  - Moshref RH
AUID- ORCID: 0000-0001-7151-295X
AD  - Department of Surgery, King Abdulaziz Medical City, Jeddah, Saudi Arabia.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20220408
PL  - United States
TA  - Am J Case Rep
JT  - The American journal of case reports
JID - 101489566
SB  - IM
MH  - *Carcinoid Tumor/complications/diagnosis/surgery
MH  - Child
MH  - *Cushing Syndrome/diagnosis
MH  - Female
MH  - Humans
MH  - *Hypertension/complications
MH  - *Multiple Endocrine Neoplasia Type 1/complications/diagnosis/pathology
MH  - Pancreas
MH  - *Pancreatic Neoplasms/complications/diagnosis/surgery
PMC - PMC9003623
COIS- Conflict of interest: None declared
EDAT- 2022/04/09 06:00
MHDA- 2022/04/12 06:00
PMCR- 2022/04/08
CRDT- 2022/04/08 05:30
PHST- 2022/04/08 05:30 [entrez]
PHST- 2022/04/09 06:00 [pubmed]
PHST- 2022/04/12 06:00 [medline]
PHST- 2022/04/08 00:00 [pmc-release]
AID - 936029 [pii]
AID - 10.12659/AJCR.936029 [doi]
PST - epublish
SO  - Am J Case Rep. 2022 Apr 8;23:e936029. doi: 10.12659/AJCR.936029.