PMID- 35394094
OWN - NLM
STAT- MEDLINE
DCOM- 20220706
LR  - 20230602
IS  - 1365-2826 (Electronic)
IS  - 0953-8194 (Print)
IS  - 0953-8194 (Linking)
VI  - 34
IP  - 6
DP  - 2022 Jun
TI  - Role of aromatase in distinct brain nuclei of the social behaviour network in the 
      expression of sexual behaviour in male Japanese quail.
PG  - e13127
LID - 10.1111/jne.13127 [doi]
AB  - In male Japanese quail, brain aromatase is crucial for the hormonal activation of 
      sexual behaviour, but the sites producing neuro-oestrogens that are critical for 
      these behaviours have not been completely identified. This study examined the 
      function of aromatase expressed in several nuclei of the social behaviour network 
      on a measure of sexual motivation known as the frequency of rhythmic cloacal 
      sphincter movements (RCSM) and on copulatory behaviour. Sexually experienced 
      castrated males chronically treated with testosterone were stereotaxically 
      implanted with the aromatase inhibitor vorozole (VOR), or cholesterol as control, 
      and tested for sexual behaviour. In experiment 1, males were implanted in the 
      medial preoptic nucleus (POM) with VOR, a manipulation known to reduce the 
      expression of copulatory behaviour. This experiment served as positive control, 
      but also showed that VOR implanted in the dorsomedial or lateral portions of the 
      POM similarly inhibits male copulatory behaviour compared to control implants. In 
      experiments 2 to 4, males received stereotaxic implants of VOR in the 
      periaqueductal gray (PAG), the nucleus taeniae of the amygdala (TnA) and the 
      ventromedial nucleus of the hypothalamus (VMN), respectively. Sexual behaviour 
      was affected only in individuals where VOR was implanted in the PAG: these males 
      displayed significantly lower frequencies of cloacal contact movements, the last 
      step of the copulatory sequence. Inhibition of aromatase in the TnA and VMN did 
      not alter copulatory ability. Overall, RCSM frequency remained unaffected by VOR 
      regardless of implantation site. Together, these results suggest that 
      neuro-oestrogens produced in the POM contribute the most to the control of male 
      copulatory behaviour, while aromatase expressed in the PAG might also participate 
      to premotor aspects of male copulatory behaviour.
CI  - (c) 2022 British Society for Neuroendocrinology.
FAU - Court, Lucas
AU  - Court L
AD  - GIGA Neurosciences, University of Liege, Liege, Belgium.
FAU - Balthazart, Jacques
AU  - Balthazart J
AUID- ORCID: 0000-0001-9492-2126
AD  - GIGA Neurosciences, University of Liege, Liege, Belgium.
FAU - Ball, Gregory F
AU  - Ball GF
AUID- ORCID: 0000-0002-4784-0520
AD  - Department of Psychology, University of Maryland, College Park, Maryland, USA.
FAU - Cornil, Charlotte A
AU  - Cornil CA
AUID- ORCID: 0000-0002-5536-7753
AD  - GIGA Neurosciences, University of Liege, Liege, Belgium.
LA  - eng
GR  - R01 MH050388/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20220408
PL  - United States
TA  - J Neuroendocrinol
JT  - Journal of neuroendocrinology
JID - 8913461
RN  - 0 (Estrogens)
RN  - 3XMK78S47O (Testosterone)
RN  - EC 1.14.14.1 (Aromatase)
SB  - IM
MH  - Animals
MH  - *Aromatase/metabolism
MH  - Brain/metabolism
MH  - *Coturnix/physiology
MH  - Estrogens
MH  - Male
MH  - Preoptic Area/metabolism
MH  - *Sexual Behavior, Animal/physiology
MH  - *Social Behavior
MH  - Testosterone/pharmacology
PMC - PMC9250618
MID - NIHMS1790961
OTO - NOTNLM
OT  - aromatase
OT  - medial preotic nucleus
OT  - neuro-oestrogens
OT  - periaqueductal gray
OT  - sexual behaviour
EDAT- 2022/04/09 06:00
MHDA- 2022/07/07 06:00
PMCR- 2023/06/01
CRDT- 2022/04/08 08:47
PHST- 2022/02/15 00:00 [revised]
PHST- 2021/11/14 00:00 [received]
PHST- 2022/03/09 00:00 [accepted]
PHST- 2022/04/09 06:00 [pubmed]
PHST- 2022/07/07 06:00 [medline]
PHST- 2022/04/08 08:47 [entrez]
PHST- 2023/06/01 00:00 [pmc-release]
AID - 10.1111/jne.13127 [doi]
PST - ppublish
SO  - J Neuroendocrinol. 2022 Jun;34(6):e13127. doi: 10.1111/jne.13127. Epub 2022 Apr 
      8.