PMID- 35394209 OWN - NLM STAT- MEDLINE DCOM- 20220919 LR - 20230204 IS - 1435-702X (Electronic) IS - 0721-832X (Print) IS - 0721-832X (Linking) VI - 260 IP - 10 DP - 2022 Oct TI - Short-term changes in Bruch's membrane opening-based morphometrics during the first week after trabeculectomy. PG - 3321-3329 LID - 10.1007/s00417-022-05644-3 [doi] AB - PURPOSE: To evaluate the dynamics of Bruch's membrane opening-based morphometrics of the optic nerve head (ONH) using spectral-domain optical coherence tomography (SD-OCT) during the first week after glaucoma surgery by trabeculectomy with mitomycin C. METHODS: Prospective, longitudinal analysis of 25 eyes of 25 patients treated by trabeculectomy. Twenty-four eyes had evaluable postoperative SD-OCT examinations. Bruch's membrane opening minimum rim width (BMO-MRW) and peripapillary retinal nerve fiber layer (RNFL) thickness were analyzed at baseline before surgery, 1 day, 2 to 3 days, and 1 week after surgery. Changes compared to baseline were correlated to intraocular pressure (IOP). RESULTS: One day after surgery, the mean BMO-MRW changed by + 26.17 microm, p = 0.001 (mean IOP reduction by 17.01 mmHg). This increase persisted on day 2-3 with a mean increase of BMO-MRW of + 25.33 microm, p = 0.001 (mean IOP reduction by 20.46 mmHg) and by week 1 with a mean BMO-MRW increase of + 33.17 microm, p < 0.001 (mean IOP reduction by 22.55 mmHg). The increase in BMO-MRW correlated significantly with the reduction of IOP on day 1 (Spearman's rho rho = 0.656, p = 0.003) and d2-3 (Spearman's rho rho = 0.479, p = 0.038). There was no statistically significant correlation found between the IOP and the increase in BMO-MRW in week 1. RNFL thickness showed no significant changes at day 1 as well as days 2-3 (p >/= 0.078, respectively). It showed a small but significant increase in week 1 by 3.94 microm, p = 0.015. CONCLUSIONS: Structural reversal of disc cupping in BMO-MRW occurs as early as 1 day after trabeculectomy and correlates to the extent of the IOP reduction. During the whole first week after surgery, a strong increase in BMO-MRW can be noted. The changes in BMO-based parameters need to be considered when evaluating patients' longitudinal follow-up. CI - (c) 2022. The Author(s). FAU - Gietzelt, Caroline AU - Gietzelt C AUID- ORCID: 0000-0002-9145-7385 AD - Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Strasse 62, 50924, Cologne, Germany. caroline.gietzelt@uk-koeln.de. AD - Glaucoma Imaging Center University of Cologne (GICC), Faculty of Medicine and University Hospital Cologne, Kerpener Strasse 62, 50924, Cologne, Germany. caroline.gietzelt@uk-koeln.de. FAU - Luke, Jan-Niklas AU - Luke JN AD - Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Strasse 62, 50924, Cologne, Germany. FAU - Adler, Werner AU - Adler W AD - Department of Medical Informatics, Biometry and Epidemiology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany. FAU - Dietlein, Thomas S AU - Dietlein TS AD - Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Strasse 62, 50924, Cologne, Germany. FAU - Lappas, Alexandra AU - Lappas A AD - Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Strasse 62, 50924, Cologne, Germany. FAU - Prokosch-Willing, Verena AU - Prokosch-Willing V AD - Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Strasse 62, 50924, Cologne, Germany. FAU - Roters, Sigrid AU - Roters S AD - Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Strasse 62, 50924, Cologne, Germany. FAU - Heindl, Ludwig M AU - Heindl LM AD - Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Strasse 62, 50924, Cologne, Germany. FAU - Cursiefen, Claus AU - Cursiefen C AD - Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Strasse 62, 50924, Cologne, Germany. FAU - Enders, Philip AU - Enders P AD - Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Strasse 62, 50924, Cologne, Germany. AD - Glaucoma Imaging Center University of Cologne (GICC), Faculty of Medicine and University Hospital Cologne, Kerpener Strasse 62, 50924, Cologne, Germany. LA - eng GR - DFG FOR 2240/Deutsche Forschungs Gesellschaft/ PT - Journal Article DEP - 20220408 PL - Germany TA - Graefes Arch Clin Exp Ophthalmol JT - Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie JID - 8205248 RN - 50SG953SK6 (Mitomycin) SB - IM MH - *Bruch Membrane MH - Humans MH - Intraocular Pressure MH - Mitomycin MH - Nerve Fibers MH - Prospective Studies MH - Retinal Ganglion Cells MH - Retrospective Studies MH - Tomography, Optical Coherence/methods MH - *Trabeculectomy MH - Visual Fields PMC - PMC8990274 OTO - NOTNLM OT - Glaucoma OT - Optic coherence tomography OT - Optic nerve head OT - Trabeculectomy COIS- The authors declare no competing interests. EDAT- 2022/04/09 06:00 MHDA- 2022/09/20 06:00 PMCR- 2022/04/08 CRDT- 2022/04/08 12:04 PHST- 2021/09/06 00:00 [received] PHST- 2022/03/24 00:00 [accepted] PHST- 2022/03/22 00:00 [revised] PHST- 2022/04/09 06:00 [pubmed] PHST- 2022/09/20 06:00 [medline] PHST- 2022/04/08 12:04 [entrez] PHST- 2022/04/08 00:00 [pmc-release] AID - 10.1007/s00417-022-05644-3 [pii] AID - 5644 [pii] AID - 10.1007/s00417-022-05644-3 [doi] PST - ppublish SO - Graefes Arch Clin Exp Ophthalmol. 2022 Oct;260(10):3321-3329. doi: 10.1007/s00417-022-05644-3. Epub 2022 Apr 8.