PMID- 35394555
OWN - NLM
STAT- MEDLINE
DCOM- 20230106
LR  - 20230111
IS  - 1863-2661 (Electronic)
IS  - 1863-2653 (Linking)
VI  - 228
IP  - 1
DP  - 2023 Jan
TI  - Coexistence of the social semantic effect and non-semantic effect in the default 
      mode network.
PG  - 321-339
LID - 10.1007/s00429-022-02476-z [doi]
AB  - Neuroimaging studies have found both semantic and non-semantic effects in the 
      default mode network (DMN), leading to an intense debate on the role of the DMN 
      in semantic processes. Four different views have been proposed: (1) the general 
      semantic view holds that the DMN contains several hub regions supporting general 
      semantic processes; (2) the non-semantic view holds that the semantic effects 
      observed in the DMN (especially the ventral angular gyrus) are confounded by 
      difficulty and do not reflect semantic processing per se; (3) the multifunction 
      view holds that the same areas in the DMN can support both semantic and 
      non-semantic functions; and (4) the multisystem view holds that the DMN contains 
      multiple subnetworks supporting different aspects of semantic processes 
      separately. Using an fMRI experiment, we found that in one of the subnetworks of 
      the DMN, called the social semantic network, all areas showed social semantic 
      activation and difficulty-induced deactivation. The distributions of two 
      non-semantic effects, that is, difficulty-induced and task-induced deactivations, 
      showed dissociation in the DMN. In the bilateral angular gyri, the ventral 
      subdivisions showed social semantic activation independent of difficulty, while 
      the dorsal subdivisions showed no semantic effect but difficulty-induced 
      activation. Our findings provide two insights into the semantic and non-semantic 
      functions of the DMN, which are consistent with both the multisystem and 
      multifunction views: first, the same areas of the DMN can support both social 
      semantic and non-semantic functions; second, similar to the multiple semantic 
      effects of the DMN, the non-semantic effects also vary across its subsystems.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Zhang, Guangyao
AU  - Zhang G
AD  - CAS Key Laboratory of Behavioral Science, Institute of Psychology.
AD  - Department of Psychology, University of Chinese Academy of Sciences.
FAU - Hung, Jinyi
AU  - Hung J
AD  - Department of Audiology and Speech Language Pathology, Mackay Medical College.
FAU - Lin, Nan
AU  - Lin N
AUID- ORCID: 0000-0003-2606-1824
AD  - CAS Key Laboratory of Behavioral Science, Institute of Psychology, . 
      linn@psych.ac.cn.
AD  - Department of Psychology, University of Chinese Academy of Sciences, . 
      linn@psych.ac.cn.
LA  - eng
GR  - 31871105/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20220408
PL  - Germany
TA  - Brain Struct Funct
JT  - Brain structure & function
JID - 101282001
SB  - IM
MH  - *Brain Mapping
MH  - *Default Mode Network
MH  - Parietal Lobe/physiology
MH  - Magnetic Resonance Imaging
MH  - Neuroimaging
MH  - Brain/diagnostic imaging/physiology
MH  - Nerve Net/diagnostic imaging/physiology
OTO - NOTNLM
OT  - Angular gyrus
OT  - Default mode network
OT  - Difficulty
OT  - Narrative
OT  - Social semantic processing
OT  - Working memory load
EDAT- 2022/04/09 06:00
MHDA- 2023/01/07 06:00
CRDT- 2022/04/08 12:11
PHST- 2021/09/26 00:00 [received]
PHST- 2022/02/23 00:00 [accepted]
PHST- 2022/04/09 06:00 [pubmed]
PHST- 2023/01/07 06:00 [medline]
PHST- 2022/04/08 12:11 [entrez]
AID - 10.1007/s00429-022-02476-z [pii]
AID - 10.1007/s00429-022-02476-z [doi]
PST - ppublish
SO  - Brain Struct Funct. 2023 Jan;228(1):321-339. doi: 10.1007/s00429-022-02476-z. 
      Epub 2022 Apr 8.