PMID- 35395159
OWN - NLM
STAT- MEDLINE
DCOM- 20220808
LR  - 20220808
IS  - 1205-7541 (Electronic)
IS  - 0008-4212 (Linking)
VI  - 100
IP  - 6
DP  - 2022 Jun 1
TI  - Restoration of cardiac metabolic flexibility by acetate in high-fat diet-induced 
      obesity is independent of ANP/BNP modulation.
PG  - 509-520
LID - 10.1139/cjpp-2021-0531 [doi]
AB  - The present study hypothesized that cardiac metabolic inflexibility is dependent 
      on cardiac atrial natriuretic peptide/brain natriuretic peptide (ANP/BNP) 
      alteration and histone deacetylase (HDAC) activity. We further sought to 
      investigate the therapeutic potential of short-chain amino acid (SCFA) acetate in 
      high-fat diet (HFD)-induced obese rat model. Adult male Wistar rats were assigned 
      into groups (n = 6 per group): Control, Obese, and Sodium acetate (NaAc)-treated 
      and Obese + NaAc-treated groups received distilled water once daily (oral 
      gavage), 40% HFD ad libitum, 200 mg/kg NaAc once daily (oral gavage), and 40% 
      HFD + NaAc, respectively. The treatments lasted for 12 weeks. HFD resulted in 
      increased food intake, body weight, and cardiac mass. It also caused insulin 
      resistance and enhanced beta-cell function, increased fasting insulin, lactate, 
      plasma and cardiac triglyceride, total cholesterol, lipid peroxidation, tumor 
      necrosis factor-alpha, interleukin-6, HDAC, and cardiac troponin T and gamma-glutamyl 
      transferase, and decreased plasma and cardiac glutathione with unaltered cardiac 
      ANP and BNP. However, these alterations were averted when treated with acetate. 
      Taken together, these results indicate that obesity induces defective cardiac 
      metabolic flexibility, which is accompanied by an elevated level of HDAC and not 
      ANP/BNP alteration. The results also suggest that acetate ameliorates 
      obesity-induced cardiac metabolic inflexibility by suppression of HDAC and 
      independent of ANP/BNP modulation.
FAU - Olaniyi, K S
AU  - Olaniyi KS
AUID- ORCID: 0000-0002-8229-9688
AD  - Cardio/Repro-metabolic and Microbiome Research Unit, Department of Physiology, 
      College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti 
      360101, Nigeria.
AD  - HOPE Cardiometabolic Research Team & Department of Physiology, College of Health 
      Sciences, University of Ilorin, P.M.B. 1515, Ilorin, 240001, Nigeria.
FAU - Atuma, C L
AU  - Atuma CL
AD  - Cardio/Repro-metabolic and Microbiome Research Unit, Department of Physiology, 
      College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti 
      360101, Nigeria.
FAU - Sabinari, I W
AU  - Sabinari IW
AD  - HOPE Cardiometabolic Research Team & Department of Physiology, College of Health 
      Sciences, University of Ilorin, P.M.B. 1515, Ilorin, 240001, Nigeria.
FAU - Hadiza, M
AU  - Hadiza M
AD  - Cardio/Repro-metabolic and Microbiome Research Unit, Department of Physiology, 
      College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti 
      360101, Nigeria.
FAU - Saidi, A O
AU  - Saidi AO
AD  - Cardio/Repro-metabolic and Microbiome Research Unit, Department of Physiology, 
      College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti 
      360101, Nigeria.
FAU - Akintayo, C O
AU  - Akintayo CO
AD  - Cardio/Repro-metabolic and Microbiome Research Unit, Department of Physiology, 
      College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti 
      360101, Nigeria.
FAU - Ajadi, I O
AU  - Ajadi IO
AD  - Department of PhysiologyCollege of Health Sciences, Ladoke AkintolaUniversity of 
      Technology, P.M.B. 4000, Ogbomoso, 210214, Nigeria.
FAU - Olatunji, L A
AU  - Olatunji LA
AD  - HOPE Cardiometabolic Research Team & Department of Physiology, College of Health 
      Sciences, University of Ilorin, P.M.B. 1515, Ilorin, 240001, Nigeria.
LA  - eng
PT  - Journal Article
DEP - 20220408
PL  - Canada
TA  - Can J Physiol Pharmacol
JT  - Canadian journal of physiology and pharmacology
JID - 0372712
RN  - 0 (Acetates)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
SB  - IM
MH  - Acetates/pharmacology
MH  - Animals
MH  - *Atrial Natriuretic Factor
MH  - Diet, High-Fat/adverse effects
MH  - Male
MH  - *Natriuretic Peptide, Brain
MH  - Obesity/complications/drug therapy
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - HDAC
OT  - acetate
OT  - acetate
OT  - cardiovasculaire
OT  - cardiovascular
OT  - metabolic flexibility
OT  - obesity
OT  - obesite
OT  - souplesse metabolique
EDAT- 2022/04/09 06:00
MHDA- 2022/08/09 06:00
CRDT- 2022/04/08 20:09
PHST- 2022/04/09 06:00 [pubmed]
PHST- 2022/08/09 06:00 [medline]
PHST- 2022/04/08 20:09 [entrez]
AID - 10.1139/cjpp-2021-0531 [doi]
PST - ppublish
SO  - Can J Physiol Pharmacol. 2022 Jun 1;100(6):509-520. doi: 10.1139/cjpp-2021-0531. 
      Epub 2022 Apr 8.